Login
Login

SPOCK1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{cs1 config|name-list-style=vanc}}

{{Infobox_gene}}

Testican-1 is a protein that in humans is encoded by the SPOCK1 gene.{{cite journal | vauthors = Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM | title = Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31 | journal = Genomics | volume = 48 | issue = 3 | pages = 377–80 |date=Jun 1998 | pmid = 9545645 | doi = 10.1006/geno.1997.5199 }}{{cite web | title = Entrez Gene: SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6695}}

This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.

References

{{reflist}}

Further reading

{{refbegin | 2}}

  • {{cite journal | vauthors=Périn JP, Alliel PM, Jollès P, Bonnet F |title=Proteoglycans in male reproductive tract |journal=Exs |volume=70 |pages= 191–7 |year= 1994 |pmid= 7507743 |doi= 10.1007/978-3-0348-7545-5_11|doi-broken-date=1 November 2024 |isbn=978-3-0348-7547-9 }}
  • {{cite journal |vauthors=Charbonnier F, Périn JP, Roussel G, etal |title=[Cloning of testican/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology] |journal=C. R. Séances Soc. Biol. Fil. |volume=191 |issue= 1 |pages= 127–33 |year= 1997 |pmid= 9181134 }}
  • {{cite journal | vauthors=Alliel PM, Perin JP, Jollès P, Bonnet FJ |title=Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour. |journal=Eur. J. Biochem. |volume=214 |issue= 1 |pages= 347–50 |year= 1993 |pmid= 8389704 |doi=10.1111/j.1432-1033.1993.tb17930.x |doi-access= }}
  • {{cite journal |vauthors=Bonnet F, Périn JP, Charbonnier F, etal |title=Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4373–80 |year= 1996 |pmid= 8626787 |doi=10.1074/jbc.271.8.4373 |doi-access= free}}
  • {{cite journal | vauthors=Marr HS, Basalamah MA, Edgell CJ |title=Endothelial cell expression of testican mRNA. |journal=Endothelium |volume=5 |issue= 3 |pages= 209–19 |year= 1998 |pmid= 9272383 |doi=10.3109/10623329709053399 }}
  • {{cite journal | vauthors=Kohfeldt E, Maurer P, Vannahme C, Timpl R |title=Properties of the extracellular calcium binding module of the proteoglycan testican. |journal=FEBS Lett. |volume=414 |issue= 3 |pages= 557–61 |year= 1997 |pmid= 9323035 |doi=10.1016/S0014-5793(97)01070-3 |s2cid=25552375 |doi-access=free |bibcode=1997FEBSL.414..557K }}
  • {{cite journal |vauthors=Marr HS, Basalamah MA, Bouldin TW, etal |title=Distribution of testican expression in human brain. |journal=Cell Tissue Res. |volume=302 |issue= 2 |pages= 139–44 |year= 2001 |pmid= 11131125 |doi=10.1007/s004410000277 |s2cid=9937680 }}
  • {{cite journal | vauthors=BaSalamah MA, Marr HS, Duncan AW, Edgell CJ |title=Testican in human blood. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 5 |pages= 1083–90 |year= 2001 |pmid= 11355883 |doi= 10.1006/bbrc.2001.4900 }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal | vauthors=Nakada M, Miyamori H, Yamashita J, Sato H |title=Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins. |journal=Cancer Res. |volume=63 |issue= 12 |pages= 3364–9 |year= 2003 |pmid= 12810672 }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Schmutz J, Martin J, Terry A, etal |title=The DNA sequence and comparative analysis of human chromosome 5. |journal=Nature |volume=431 |issue= 7006 |pages= 268–74 |year= 2004 |pmid= 15372022 |doi= 10.1038/nature02919 |bibcode=2004Natur.431..268S |doi-access= free }}
  • {{cite journal |vauthors=Prenzel KL, Warnecke-Eberz U, Xi H, etal |title=Significant overexpression of SPARC/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater. |journal=Oncol. Rep. |volume=15 |issue= 5 |pages= 1397–401 |year= 2006 |pmid= 16596217 |doi= 10.3892/or.15.5.1397|doi-access=free }}

{{refend}}

Category:Testicans

{{gene-5-stub}}