SPTBN5
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.{{cite journal | vauthors = Stabach PR, Morrow JS | title = Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21385–95 |date=July 2000 | pmid = 10764729 | doi = 10.1074/jbc.C000159200 | doi-access = free }} SPTBN5 belongs to the spectrin family of cytoskeletal proteins.
Structure and function
SPTBN5 contains the following domains:
- actin-binding domain
- membrane-association domain-1
- self-association domain
- C-terminal pleckstrin homology domain.
Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.
SPTBN5 is highly expressed in embryoid bodies.{{cite journal | vauthors = Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A | title = Temporal analysis of neural differentiation using quantitative proteomics | journal = J. Proteome Res. | volume = 8| issue = 3| pages = 1315–26|date=January 2009 | pmid = 19173612 | doi = 10.1021/pr8006667 | pmc = 2693473 }}
References
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Further reading
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- {{cite journal |vauthors=Odell AF, Van Helden DF, Scott JL |title=The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels |journal=J. Biol. Chem. |volume=283 |issue= 7 |pages= 4395–407 |year= 2008 |pmid= 18048348 |doi= 10.1074/jbc.M709729200 |doi-access= free |hdl= 1959.13/39937 |hdl-access= free }}
- {{cite journal |vauthors=Oguri M, Kato K, Yokoi K, etal |title=Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals |journal=Am. J. Hypertens. |volume=23 |issue= 1 |pages= 70–7 |year= 2010 |pmid= 19851296 |doi= 10.1038/ajh.2009.190 |doi-access= free }}
- {{cite journal |vauthors=Shoeman RL, Hartig R, Hauses C, Traub P |title=Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease |journal=Cell Biol. Int. |volume=26 |issue= 6 |pages= 529–39 |year= 2002 |pmid= 12119179 |doi=10.1006/cbir.2002.0895 |s2cid=39778155 }}
- {{cite journal |vauthors=Chardin P, Camonis JH, Gale NW, etal |title=Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2 |journal=Science |volume=260 |issue= 5112 |pages= 1338–43 |year= 1993 |pmid= 8493579 |doi=10.1126/science.8493579 |bibcode=1993Sci...260.1338C }}
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{{Cytoskeletal Proteins}}
{{gene-15-stub}}