SRRM1

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Serine/arginine repetitive matrix protein 1 is a protein that in humans is encoded by the SRRM1 gene.{{cite journal | vauthors = Blencowe BJ, Issner R, Nickerson JA, Sharp PA | title = A coactivator of pre-mRNA splicing | journal = Genes Dev. | volume = 12 | issue = 7 | pages = 996–1009 | date = May 1998 | pmid = 9531537 | pmc = 316672 | doi = 10.1101/gad.12.7.996 }}{{cite web | title = Entrez Gene: SRRM1 serine/arginine repetitive matrix 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10250}}

Interactions

SRRM1 has been shown to interact with CDC5L.{{cite journal | vauthors = Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI | title = Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6569–81 | date = December 2000 | pmid = 11101529 | pmc = 305846 | doi = 10.1093/emboj/19.23.6569 }}

References

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Further reading

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  • {{cite journal | vauthors = Wang HY, Lin W, Dyck JA, Yeakley JM, Songyang Z, Cantley LC, Fu XD | title = SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells | journal = J. Cell Biol. | volume = 140 | issue = 4 | pages = 737–50 | year = 1998 | pmid = 9472028 | pmc = 2141757 | doi = 10.1083/jcb.140.4.737 }}
  • {{cite journal | vauthors = Wilson KF, Fortes P, Singh US, Ohno M, Mattaj IW, Cerione RA | title = The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction | journal = J. Biol. Chem. | volume = 274 | issue = 7 | pages = 4166–73 | year = 1999 | pmid = 9933612 | doi = 10.1074/jbc.274.7.4166 | doi-access = free }}
  • {{cite journal | vauthors = Eldridge AG, Li Y, Sharp PA, Blencowe BJ | title = The SRm160/300 splicing coactivator is required for exon-enhancer function | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 11 | pages = 6125–30 | year = 1999 | pmid = 10339552 | pmc = 26846 | doi = 10.1073/pnas.96.11.6125 | bibcode = 1999PNAS...96.6125E | doi-access = free }}
  • {{cite journal | vauthors = Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA | title = The SRm160/300 splicing coactivator subunits | journal = RNA | volume = 6 | issue = 1 | pages = 111–20 | year = 2000 | pmid = 10668804 | pmc = 1369899 | doi = 10.1017/S1355838200991982 }}
  • {{cite journal | vauthors = Le Hir H, Moore MJ, Maquat LE | title = Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1098–108 | year = 2000 | doi = 10.1101/gad.14.9.1098 | pmid = 10809668 | pmc = 316578 }}
  • {{cite journal | vauthors = McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ | title = The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes | journal = J. Cell Biol. | volume = 150 | issue = 2 | pages = 309–20 | year = 2000 | pmid = 10908574 | pmc = 2180225 | doi = 10.1083/jcb.150.2.309 }}
  • {{cite journal | vauthors = Le Hir H, Izaurralde E, Maquat LE, Moore MJ | title = The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions | journal = EMBO J. | volume = 19 | issue = 24 | pages = 6860–9 | year = 2000 | pmid = 11118221 | pmc = 305905 | doi = 10.1093/emboj/19.24.6860 }}
  • {{cite journal | vauthors = Lykke-Andersen J, Shu MD, Steitz JA | title = Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1 | journal = Science | volume = 293 | issue = 5536 | pages = 1836–9 | year = 2001 | pmid = 11546874 | doi = 10.1126/science.1062786 | bibcode = 2001Sci...293.1836L | s2cid = 389385 }}
  • {{cite journal | vauthors = McCracken S, Lambermon M, Blencowe BJ | title = SRm160 splicing coactivator promotes transcript 3'-end cleavage | journal = Mol. Cell. Biol. | volume = 22 | issue = 1 | pages = 148–60 | year = 2002 | pmid = 11739730 | pmc = 134228 | doi = 10.1128/MCB.22.1.148-160.2002 }}
  • {{cite journal | vauthors = Szymczyna BR, Pineda-Lucena A, Mills JL, Szyperski T, Arrowsmith CH | title = 1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR | journal = J. Biomol. NMR | volume = 22 | issue = 3 | pages = 299–300 | year = 2002 | pmid = 11991360 | doi = 10.1023/A:1014904502424 | s2cid = 13594831 }}
  • {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
  • {{cite journal | vauthors = Lejeune F, Ishigaki Y, Li X, Maquat LE | title = The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling | journal = EMBO J. | volume = 21 | issue = 13 | pages = 3536–45 | year = 2002 | pmid = 12093754 | pmc = 126094 | doi = 10.1093/emboj/cdf345 }}
  • {{cite journal | vauthors = Meissner M, Lopato S, Gotzmann J, Sauermann G, Barta A | title = Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins | journal = Exp. Cell Res. | volume = 283 | issue = 2 | pages = 184–95 | year = 2003 | pmid = 12581738 | doi = 10.1016/S0014-4827(02)00046-0 }}
  • {{cite journal | vauthors = Szymczyna BR, Bowman J, McCracken S, Pineda-Lucena A, Lu Y, Cox B, Lambermon M, Graveley BR, Arrowsmith CH, Blencowe BJ | title = Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing | journal = Genes Dev. | volume = 17 | issue = 4 | pages = 461–75 | year = 2003 | pmid = 12600940 | pmc = 196000 | doi = 10.1101/gad.1060403 }}
  • {{cite journal | vauthors = Wagner S, Chiosea S, Nickerson JA | title = The spatial targeting and nuclear matrix binding domains of SRm160 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 6 | pages = 3269–74 | year = 2003 | pmid = 12624182 | pmc = 152281 | doi = 10.1073/pnas.0438055100 | bibcode = 2003PNAS..100.3269W | doi-access = free }}
  • {{cite journal | vauthors = McCracken S, Longman D, Johnstone IL, Cáceres JF, Blencowe BJ | title = An evolutionarily conserved role for SRm160 in 3'-end processing that functions independently of exon junction complex formation | journal = J. Biol. Chem. | volume = 278 | issue = 45 | pages = 44153–60 | year = 2003 | pmid = 12944400 | doi = 10.1074/jbc.M306856200 | doi-access = free }}
  • {{cite journal | vauthors = Wagner S, Chiosea S, Ivshina M, Nickerson JA | title = In vitro FRAP reveals the ATP-dependent nuclear mobilization of the exon junction complex protein SRm160 | journal = J. Cell Biol. | volume = 164 | issue = 6 | pages = 843–50 | year = 2004 | pmid = 15024032 | pmc = 2172284 | doi = 10.1083/jcb.200307002 }}
  • {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Anal. Chem. | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}

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