SSH1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
For the SSH-1 protocol, see Secure Shell#Version 1
Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 1 | pages = 65–73 |date=Apr 2000 | pmid = 10718198 | doi =10.1093/dnares/7.1.65 | doi-access = free }}{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 |date=Feb 2002 | pmid = 11832213 | doi =10.1016/S0092-8674(01)00638-9 | s2cid = 5576208 | doi-access = free }}{{cite web | title = Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54434}}
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]
References
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Further reading
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- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Endo M, Ohashi K, Sasaki Y, etal |title=Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. |journal=J. Neurosci. |volume=23 |issue= 7 |pages= 2527–37 |year= 2003 |pmid= 12684437 |doi= 10.1523/JNEUROSCI.23-07-02527.2003|pmc=6742113 |doi-access=free }}
- {{cite journal |vauthors=Kaji N, Ohashi K, Shuin M, etal |title=Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33450–5 |year= 2003 |pmid= 12807904 |doi= 10.1074/jbc.M305802200 |doi-access= free }}
- {{cite journal |vauthors=Ohta Y, Kousaka K, Nagata-Ohashi K, etal |title=Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. |journal=Genes Cells |volume=8 |issue= 10 |pages= 811–24 |year= 2004 |pmid= 14531860 |doi=10.1046/j.1365-2443.2003.00678.x |s2cid=24247372 |doi-access=free }}
- {{cite journal |vauthors=Nishita M, Wang Y, Tomizawa C, etal |title=Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7193–8 |year= 2004 |pmid= 14645219 |doi= 10.1074/jbc.M312591200 |doi-access= free }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
- {{cite journal |vauthors=Dai S, Sarmiere PD, Wiggan O, etal |title=Efficient Salmonella entry requires activity cycles of host ADF and cofilin. |journal=Cell. Microbiol. |volume=6 |issue= 5 |pages= 459–71 |year= 2004 |pmid= 15056216 |doi= 10.1111/j.1462-5822.2004.00375.x |s2cid=20238982 |doi-access=free }}
- {{cite journal |vauthors=Nagata-Ohashi K, Ohta Y, Goto K, etal |title=A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 465–71 |year= 2004 |pmid= 15159416 |doi= 10.1083/jcb.200401136 | pmc=2172350 }}
- {{cite journal |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 |bibcode=2004PNAS..10112130B |doi-access=free }}
- {{cite journal |vauthors=Zhang Z, Niu Z, Yuan W, etal |title=Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. |journal=Hum. Mutat. |volume=24 |issue= 5 |pages= 438 |year= 2005 |pmid= 15459975 |doi= 10.1002/humu.9283 |s2cid=22946257 |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Soosairajah J, Maiti S, Wiggan O, etal |title=Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. |journal=EMBO J. |volume=24 |issue= 3 |pages= 473–86 |year= 2005 |pmid= 15660133 |doi= 10.1038/sj.emboj.7600543 | pmc=548651 }}
- {{cite journal | vauthors=Wang Y, Shibasaki F, Mizuno K |title=Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12683–9 |year= 2005 |pmid= 15671020 |doi= 10.1074/jbc.M411494200 |doi-access= free }}
- {{cite journal |vauthors=Nishita M, Tomizawa C, Yamamoto M, etal |title=Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. |journal=J. Cell Biol. |volume=171 |issue= 2 |pages= 349–59 |year= 2006 |pmid= 16230460 |doi= 10.1083/jcb.200504029 | pmc=2171197 }}
- {{cite journal |vauthors=Yamamoto M, Nagata-Ohashi K, Ohta Y, etal |title=Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L. |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1789–94 |year= 2006 |pmid= 16513117 |doi= 10.1016/j.febslet.2006.02.034 |s2cid=27347823 |doi-access=free }}
- {{cite journal |vauthors=Cai L, Marshall TW, Uetrecht AC, etal |title=Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. |journal=Cell |volume=128 |issue= 5 |pages= 915–29 |year= 2007 |pmid= 17350576 |doi= 10.1016/j.cell.2007.01.031 | pmc=2630706 }}
- {{cite journal |vauthors=Kligys K, Claiborne JN, DeBiase PJ, etal |title=The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32520–8 |year= 2007 |pmid= 17848544 |doi= 10.1074/jbc.M707041200 | pmc=2754063 |doi-access=free }}
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{{Protein tyrosine phosphatases}}
{{gene-12-stub}}