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SSH2

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

{{For|the SSH-2 protocol|Secure Shell#Version 2}}

Protein phosphatase Slingshot homolog 2 is an enzyme that in humans is encoded by the SSH2 gene.{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 |date=Feb 2002 | pmid = 11832213 | doi =10.1016/S0092-8674(01)00638-9 | s2cid = 5576208 | doi-access = free }}{{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 6 | pages = 347–55 |date=Feb 2001 | pmid = 11214970 | doi =10.1093/dnares/7.6.347 | doi-access = free }}{{cite web | title = Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85464}}

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]{{cite web | title = Entrez Gene: SSH2 slingshot homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=85464}}

References

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Further reading

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  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Chan SY, Chan AK, Cheung BP, etal |title=Identification of genes expressed during myocardial development. |journal=Chin. Med. J. |volume=116 |issue= 9 |pages= 1329–32 |year= 2004 |pmid= 14527359 }}
  • {{cite journal |vauthors=Ohta Y, Kousaka K, Nagata-Ohashi K, etal |title=Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. |journal=Genes Cells |volume=8 |issue= 10 |pages= 811–24 |year= 2004 |pmid= 14531860 |doi=10.1046/j.1365-2443.2003.00678.x |s2cid=24247372 |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 |doi-access= free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Soosairajah J, Maiti S, Wiggan O, etal |title=Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. |journal=EMBO J. |volume=24 |issue= 3 |pages= 473–86 |year= 2005 |pmid= 15660133 |doi= 10.1038/sj.emboj.7600543 | pmc=548651 }}
  • {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
  • {{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F, etal |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |s2cid=7827573 |doi-access=free }}
  • {{cite journal |vauthors=Kligys K, Claiborne JN, DeBiase PJ, etal |title=The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32520–8 |year= 2007 |pmid= 17848544 |doi= 10.1074/jbc.M707041200 | pmc=2754063 |doi-access=free }}

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External links

  • {{PDBe-KB2|Q76I76|Protein phosphatase Slingshot homolog 2}}

{{PDB Gallery|geneid=85464}}

{{Protein tyrosine phosphatases}}

{{gene-17-stub}}