SSH3
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Protein phosphatase Slingshot homolog 3 is an enzyme that in humans is encoded by the SSH3 gene.{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 | date = January 2002 | pmid = 11832213 | doi = 10.1016/S0092-8674(01)00638-9 | s2cid = 5576208 | doi-access = free }}{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961}}
Function
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]{{cite web | title = Entrez Gene: SSH3 slingshot homolog 3 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54961}}
References
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Further reading
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- {{cite journal | vauthors = Kligys K, Claiborne JN, DeBiase PJ, Hopkinson SB, Wu Y, Mizuno K, Jones JC | title = The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes | journal = The Journal of Biological Chemistry | volume = 282 | issue = 44 | pages = 32520–8 | date = November 2007 | pmid = 17848544 | pmc = 2754063 | doi = 10.1074/jbc.M707041200 | doi-access = free }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
- {{cite journal | vauthors = Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, Sampath R, Bamburg JR, Bernard O | title = Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin | journal = The EMBO Journal | volume = 24 | issue = 3 | pages = 473–86 | date = February 2005 | pmid = 15660133 | pmc = 548651 | doi = 10.1038/sj.emboj.7600543 }}
- {{cite journal | vauthors = Ohta Y, Kousaka K, Nagata-Ohashi K, Ohashi K, Muramoto A, Shima Y, Niwa R, Uemura T, Mizuno K | title = Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin | journal = Genes to Cells | volume = 8 | issue = 10 | pages = 811–24 | date = October 2003 | pmid = 14531860 | doi = 10.1046/j.1365-2443.2003.00678.x | s2cid = 24247372 | doi-access = }}
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{{Protein tyrosine phosphatases}}
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