SSMEM1
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox gene}}
Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.{{Cite encyclopedia|title=serine-rich single-pass membrane protein 1 [Homo sapiens]|encyclopedia=Protein|publisher=NCBI|id=NP_660311.1|url=https://www.ncbi.nlm.nih.gov/protein/NP_660311.1|access-date=2016-12-16|date=26 August 2016}}
Gene
The gene and intron-exon structure were first predicted through analysis of the complete sequence of human chromosome 7, its initial designation being C7orf45.{{Cite web|url=http://www.chr7.org/cgi-bin/gbrowse/gbrowse/chr7_v2/?name=Gene%3AC7orf45%7CNM_145268.2;addlabel=NCBI_RefSeq|title=Showing 9.782 kbp from Chr7, positions 129,233,084 to 129,242,865|date=June 2004|publisher=The Chromosome 7 Annotation Project|at=Landmark or Region: Gene:C7orf45{{!}}NM_145268.2|access-date=2016-12-16}}{{Cite journal|year=2003|title=Human Chromosome 7: DNA Sequence and Biology|journal=Science|volume=300|issue=5620|pages=767–772|doi=10.1126/science.1083423|pmc=2882961|vauthors=Scherer SW, Cheung J, MacDonald JR, et al.|pmid=12690205|bibcode=2003Sci...300..767S}} Human mRNA transcripts were identified through two large scale cDNA cloning efforts, an American effort run out of the Dana-Farber Cancer Institute and Harvard Medical School, and full-length long Japan effort. Later assigned the official symbol SSMEM1, the gene is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.{{Cite encyclopedia|title=SSMEM1 serine rich single-pass membrane protein 1 [ Homo sapiens (human) ]|encyclopedia=Gene|publisher=NCBI|id=136263|url=https://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=21687171|access-date=2016-12-16|date=6 December 2016}} The human mRNA transcript is 1171 bp long with three exons.{{Cite encyclopedia|title=Homo sapiens serine rich single-pass membrane protein 1 (SSMEM1), mRNA|encyclopedia=Nucleotide|publisher=NCBI|id=NM_145268.3|url=https://www.ncbi.nlm.nih.gov/nuccore/197304739|access-date=2016-12-16|date=26 August 2016}}
=Aliases=
=Expression=
In humans, SSMEM1 is highly expressed in the testes.{{Cite web | url=http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8586006 |title = United States Patent: 8586006 - Organ-specific proteins and methods of their use}}{{Failed verification|date=December 2016}}{{Cite encyclopedia|title=Est Profile - Hs.351816|encyclopedia=UniGene|publisher=NCBI|url=https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.351816|date=2016}}{{Cite web|url=https://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3834:4246|title=GDS3834 / 4246|website=www.ncbi.nlm.nih.gov|access-date=2016-12-17}} In mice, SSMEM1 is expressed in the brain.{{Cite web|url=http://mouse.brain-map.org/gene/show/51488|title=Gene Detail :: Allen Brain Atlas: Mouse Brain|website=mouse.brain-map.org|access-date=2016-12-17}}
Protein
In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55. This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243). DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long. The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.{{Cite web|url=http://www.phosphosite.org/proteinAction.do?id=13271515&showAllSites=true|title=SSMEM1 (human)|website=www.phosphosite.org|access-date=2016-12-17}}
References
{{reflist|33em}}