SSR2

{{Short description|Protein-coding gene in the species Homo sapiens}}

Translocon-associated protein subunit beta also known as TRAP-beta is a protein that in humans is encoded by the SSR2 gene.{{cite journal | vauthors = Chinen K, Sudo K, Takahashi E, Nakamura Y | title = Isolation and mapping of the human beta-signal sequence receptor gene (SSR2) | journal = Cytogenetics and Cell Genetics | volume = 70 | issue = 3–4 | pages = 215–7 | date = Jul 1995 | pmid = 7789174 | doi = 10.1159/000134036 }}{{cite web | title = Entrez Gene: SSR2 signal sequence receptor, beta (translocon-associated protein beta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6746}}

Function

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein (alpha-SSR or SSR1) and a 22-kD glycoprotein (beta-SSR or SSR2). The human beta-signal sequence receptor gene (SSR2) maps to chromosome bands 1q21-q23.

References

{{cite journal | vauthors = Tajima S, Lauffer L, Rath VL, Walter P | title = The signal recognition particle receptor is a complex that contains two distinct polypeptide chains | journal = The Journal of Cell Biology | volume = 103 | issue = 4 | pages = 1167–78 | date = October 1986 | pmid = 3021779 | pmc = 2114348 | doi = 10.1083/jcb.103.4.1167 }}
{{cite journal | vauthors = Hartmann E, Görlich D, Kostka S, Otto A, Kraft R, Knespel S, Bürger E, Rapoport TA, Prehn S | title = A tetrameric complex of membrane proteins in the endoplasmic reticulum | journal = European Journal of Biochemistry | volume = 214 | issue = 2 | pages = 375–81 | date = June 1993 | pmid = 7916687 | doi = 10.1111/j.1432-1033.1993.tb17933.x | hdl = 11858/00-001M-0000-0015-3BD2-F | hdl-access = free }}
{{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
{{cite journal | vauthors = Bodescot M, Brison O | title = Cloning and sequence analysis of the beta subunit of the human translocon-associated protein | journal = Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression | volume = 1217 | issue = 1 | pages = 101–2 | date = January 1994 | pmid = 8286409 | doi = 10.1016/0167-4781(94)90131-7 }}
{{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
{{cite journal | vauthors = Wang L, Dobberstein B | title = Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum | journal = FEBS Letters | volume = 457 | issue = 3 | pages = 316–22 | date = September 1999 | pmid = 10471800 | doi = 10.1016/S0014-5793(99)01075-3 | doi-access = free }}
{{cite journal | vauthors = Zhang H, Li XJ, Martin DB, Aebersold R | title = Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry | journal = Nature Biotechnology | volume = 21 | issue = 6 | pages = 660–6 | date = June 2003 | pmid = 12754519 | doi = 10.1038/nbt827 | s2cid = 581283 }}
{{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = September 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}

SSR2

Function

References

Further reading