STATH

{{Short description|Protein-coding gene in humans}}

{{Infobox_gene}}

Statherin is a protein in humans that is encoded by the STATH gene.{{cite journal | vauthors = Sabatini LM, Carlock LR, Johnson GW, Azen EA | title = cDNA cloning and chromosomal localization (4q11-13) of a gene for statherin, a regulator of calcium in saliva | journal = Am J Hum Genet | volume = 41 | issue = 6 | pages = 1048–60 | date = Jan 1988 | pmid = 3502720 | pmc = 1684366 }}{{cite web | title = Entrez Gene: STATH statherin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6779}} It prevents the precipitation of calcium phosphate in saliva, maintaining a high calcium level in saliva available for remineralisation of tooth enamel and high phosphate levels for buffering.{{cite journal | vauthors = Hay DI, Smith DJ, Schluckebier SK, Moreno EC | title = Relationship between concentration of human salivary statherin and inhibition of calcium phosphate precipitation in stimulated human parotid saliva | journal = J. Dent. Res. | volume = 63 | issue = 6 | pages = 857–63 | year = 1984 | pmid = 6429216 | doi = 10.1177/00220345840630060901| s2cid = 72916849 }}

References

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Further reading

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  • {{cite journal | vauthors = Schlesinger DH, Hay DI | title = Complete covalent structure of statherin, a tyrosine-rich acidic peptide which inhibits calcium phosphate precipitation from human parotid saliva | journal = J. Biol. Chem. | volume = 252 | issue = 5 | pages = 1689–95 | year = 1977 | doi = 10.1016/S0021-9258(17)40603-X | pmid = 838735 | doi-access = free }}
  • {{cite journal | vauthors = Raj PA, Johnsson M, Levine MJ, Nancollas GH | title = Salivary statherin. Dependence on sequence, charge, hydrogen bonding potency, and helical conformation for adsorption to hydroxyapatite and inhibition of mineralization | journal = J. Biol. Chem. | volume = 267 | issue = 9 | pages = 5968–76 | year = 1992 | doi = 10.1016/S0021-9258(18)42650-6 | pmid = 1313424 | doi-access = free }}
  • {{cite journal | vauthors = Douglas WH, Reeh ES, Ramasubbu N, Raj PA, Bhandary KK, Levine MJ | title = Statherin: a major boundary lubricant of human saliva | journal = Biochem. Biophys. Res. Commun. | volume = 180 | issue = 1 | pages = 91–7 | year = 1991 | pmid = 1718282 | doi = 10.1016/S0006-291X(05)81259-8 }}
  • {{cite journal | vauthors = Johnsson M, Richardson CF, Bergey EJ, Levine MJ, Nancollas GH | title = The effects of human salivary cystatins and statherin on hydroxyapatite crystallization | journal = Arch. Oral Biol. | volume = 36 | issue = 9 | pages = 631–6 | year = 1992 | pmid = 1741693 | doi = 10.1016/0003-9969(91)90014-L }}
  • {{cite journal | vauthors = Ramasubbu N, Reddy MS, Bergey EJ, Haraszthy GG, Soni SD, Levine MJ | title = Large-scale purification and characterization of the major phosphoproteins and mucins of human submandibular-sublingual saliva | journal = Biochem. J. | volume = 280 ( Pt 2) | issue = Pt 2 | pages = 341–52 | year = 1992 | pmid = 1747107 | pmc = 1130552 | doi = 10.1042/bj2800341}}
  • {{cite journal | vauthors = Sabatini LM, He YZ, Azen EA | title = Structure and sequence determination of the gene encoding human salivary statherin | journal = Gene | volume = 89 | issue = 2 | pages = 245–51 | year = 1990 | pmid = 2373369 | doi = 10.1016/0378-1119(90)90012-G }}
  • {{cite journal | vauthors = Sabatini LM, Warner TF, Saitoh E, Azen EA | title = Tissue distribution of RNAs for cystatins, histatins, statherin, and proline-rich salivary proteins in humans and macaques | journal = J. Dent. Res. | volume = 68 | issue = 7 | pages = 1138–45 | year = 1990 | pmid = 2483725 | doi = 10.1177/00220345890680070101 | s2cid = 36679891 }}
  • {{cite journal | vauthors = Dickinson DP, Ridall AL, Levine MJ | title = Human submandibular gland statherin and basic histidine-rich peptide are encoded by highly abundant mRNA's derived from a common ancestral sequence | journal = Biochem. Biophys. Res. Commun. | volume = 149 | issue = 2 | pages = 784–90 | year = 1988 | pmid = 3426601 | doi = 10.1016/0006-291X(87)90436-0 }}
  • {{cite journal | vauthors = Oppenheim FG, Hay DI, Smith DJ, Offner GD, Troxler RF | title = Molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mRNAs and partial amino acid sequence of their signal peptides | journal = J. Dent. Res. | volume = 66 | issue = 2 | pages = 462–6 | year = 1987 | pmid = 3476566 | doi = 10.1177/00220345870660021301 | s2cid = 22104713 }}
  • {{cite journal | vauthors = Perinpanayagam HE, Van Wuyckhuyse BC, Ji ZS, Tabak LA | title = Characterization of low-molecular-weight peptides in human parotid saliva | journal = J. Dent. Res. | volume = 74 | issue = 1 | pages = 345–50 | year = 1995 | pmid = 7876428 | doi = 10.1177/00220345950740011001 | s2cid = 19598742 }}
  • {{cite journal | vauthors = Gururaja TL, Levine MJ | title = Solid-phase synthesis and characterization of human salivary statherin: a tyrosine-rich phosphoprotein inhibitor of calcium phosphate precipitation | journal = Pept. Res. | volume = 9 | issue = 6 | pages = 283–9 | year = 1997 | pmid = 9048421 }}
  • {{cite journal | vauthors = Iontcheva I, Oppenheim FG, Troxler RF | title = Human salivary mucin MG1 selectively forms heterotypic complexes with amylase, proline-rich proteins, statherin, and histatins | journal = J. Dent. Res. | volume = 76 | issue = 3 | pages = 734–43 | year = 1997 | pmid = 9109822 | doi = 10.1177/00220345970760030501 | s2cid = 39525421 }}
  • {{cite journal | vauthors = Iontcheva I, Oppenheim FG, Offner GD, Troxler RF | title = Molecular mapping of statherin- and histatin-binding domains in human salivary mucin MG1 (MUC5B) by the yeast two-hybrid system | journal = J. Dent. Res. | volume = 79 | issue = 2 | pages = 732–9 | year = 2000 | pmid = 10728974 | doi = 10.1177/00220345000790020601 | s2cid = 27558675 }}
  • {{cite journal | vauthors = Gilbert M, Shaw WJ, Long JR, Nelson K, Drobny GP, Giachelli CM, Stayton PS | title = Chimeric peptides of statherin and osteopontin that bind hydroxyapatite and mediate cell adhesion | journal = J. Biol. Chem. | volume = 275 | issue = 21 | pages = 16213–8 | year = 2000 | pmid = 10748043 | doi = 10.1074/jbc.M001773200 | doi-access = free }}
  • {{cite journal | vauthors = Yao Y, Lamkin MS, Oppenheim FG | title = Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin generated by transglutaminase | journal = J. Dent. Res. | volume = 79 | issue = 4 | pages = 930–8 | year = 2000 | pmid = 10831095 | doi = 10.1177/00220345000790040801 | s2cid = 37029459 }}
  • {{cite journal | vauthors = Tamaki N, Tada T, Morita M, Watanabe T | title = Comparison of inhibitory activity on calcium phosphate precipitation by acidic proline-rich proteins, statherin, and histatin-1 | journal = Calcif. Tissue Int. | volume = 71 | issue = 1 | pages = 59–62 | year = 2003 | pmid = 12060866 | doi = 10.1007/s00223-001-1084-0 | s2cid = 38221230 }}
  • {{cite journal | vauthors = Yao Y, Berg EA, Costello CE, Troxler RF, Oppenheim FG | title = Identification of protein components in human acquired enamel pellicle and whole saliva using novel proteomics approaches | journal = J. Biol. Chem. | volume = 278 | issue = 7 | pages = 5300–8 | year = 2003 | pmid = 12444093 | doi = 10.1074/jbc.M206333200 | doi-access = free }}

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