STAU2
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.{{cite journal | vauthors = Buchner G, Bassi MT, Andolfi G, Ballabio A, Franco B | title = Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region | journal = Genomics | volume = 62 | issue = 1 | pages = 113–8 | date = November 1999 | pmid = 10585778 | doi = 10.1006/geno.1999.6015 }}{{cite web | title = Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27067 }}
Function
Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis.{{Cite journal|last1=Cockburn|first1=Diane M.|last2=Charish|first2=Jason|last3=Tassew|first3=Nardos G.|last4=Eubanks|first4=James|last5=Bremner|first5=Rod|last6=Macchi|first6=Paolo|last7=Monnier|first7=Philippe P.|date=November 2012|title=The double-stranded RNA-binding protein Staufen 2 regulates eye size|url=https://linkinghub.elsevier.com/retrieve/pii/S1044743112001352|journal=Molecular and Cellular Neuroscience|language=en|volume=51|issue=3–4|pages=101–111|doi=10.1016/j.mcn.2012.08.008|pmid=22940085|s2cid=5193038}}
Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev {{Cite journal|last1=Banerjee|first1=Atoshi|last2=Benjamin|first2=Ronald|last3=Balakrishnan|first3=Kannan|last4=Ghosh|first4=Payel|last5=Banerjee|first5=Sharmistha|date=2014-02-13|title=Human protein Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev|journal=Retrovirology|volume=11|pages=18|doi=10.1186/1742-4690-11-18|issn=1742-4690|pmc=4016256|pmid=24520823 |doi-access=free }} and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity{{Cite journal|last1=Balakrishnan|first1=Kannan|last2=Jaguva Vasudevan|first2=Ananda|last3=Mohareer|first3=Krishnaveni|last4=Luedde|first4=Tom|last5=Münk|first5=Carsten|last6=Banerjee|first6=Sharmistha|date=2021-12-08|title=Encapsidation of Staufen-2 Enhances Infectivity of HIV-1|journal=Viruses|language=en|volume=13|issue=12|pages=2459|doi=10.3390/v13122459|issn=1999-4915|pmc=8703407|pmid=34960728|doi-access=free}}
References
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Further reading
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- {{cite journal | vauthors = Kiebler MA, DesGroseillers L | title = Molecular insights into mRNA transport and local translation in the mammalian nervous system | journal = Neuron | volume = 25 | issue = 1 | pages = 19–28 | date = January 2000 | pmid = 10707969 | doi = 10.1016/S0896-6273(00)80868-5 | s2cid = 2565210 | doi-access = free }}
- {{cite journal | vauthors = Furic L, Maher-Laporte M, DesGroseillers L | title = A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes | journal = RNA | volume = 14 | issue = 2 | pages = 324–35 | date = February 2008 | pmid = 18094122 | pmc = 2212254 | doi = 10.1261/rna.720308 }}
- {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
- {{cite journal | vauthors = Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ | title = Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles | journal = Molecular and Cellular Biology | volume = 24 | issue = 7 | pages = 2637–48 | date = April 2004 | pmid = 15024055 | pmc = 371130 | doi = 10.1128/MCB.24.7.2637-2648.2004 }}
- {{cite journal | vauthors = Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L | title = Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles | journal = Journal of Cell Science | volume = 115 | issue = Pt 16 | pages = 3285–95 | date = August 2002 | doi = 10.1242/jcs.115.16.3285 | pmid = 12140260 }}
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{{PDB Gallery|geneid=27067}}
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