STEAP1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene.{{cite web | title = Entrez Gene: STEAP1 six transmembrane epithelial antigen of the prostate 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26872}}
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
References
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Further reading
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- {{cite journal |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097|doi-access=free |last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }}
- {{cite journal |vauthors=Hubert RS, Vivanco I, Chen E, etal |title=STEAP: A prostate-specific cell-surface antigen highly expressed in human prostate tumors |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 25 |pages= 14523–8 |year= 2000 |pmid= 10588738 |doi=10.1073/pnas.96.25.14523 | pmc=24469 |doi-access=free }}
- {{cite journal |vauthors=Yang D, Holt GE, Velders MP, etal |title=Murine six-transmembrane epithelial antigen of the prostate, prostate stem cell antigen, and prostate-specific membrane antigen: prostate-specific cell-surface antigens highly expressed in prostate cancer of transgenic adenocarcinoma mouse prostate mice |journal=Cancer Res. |volume=61 |issue= 15 |pages= 5857–60 |year= 2001 |pmid= 11479226 }}
- {{cite journal |vauthors=Korkmaz KS, Elbi C, Korkmaz CG, etal |title=Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36689–96 |year= 2002 |pmid= 12095985 |doi= 10.1074/jbc.M202414200 |doi-access= free }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |bibcode=2003Sci...300..767S }}
- {{cite journal |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal | vauthors=Rodeberg DA, Nuss RA, Elsawa SF, Celis E |title=Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes |journal=Clin. Cancer Res. |volume=11 |issue= 12 |pages= 4545–52 |year= 2005 |pmid= 15958640 |doi= 10.1158/1078-0432.CCR-04-2235 | pmc=1698136 }}
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