STX6

STX6 has been shown to interact with SNAP23,{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = October 2000 | doi = 10.1182/blood.V96.7.2574 | pmid = 11001914 }} VAMP3{{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | display-authors = 6 | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = February 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }} and VAMP4.

The protein domain Syntaxin 6 N terminal protein domain is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) found in endosomal transport vesicles. It is part of the family, of target SNAREs (t-SNAREs). It is a vital aid to exporting and importing cell cargo through a process called cell trafficking. Its SNARE motif shows significant homology to both syntaxin 1a and S25C, indicating similarity through evolutionary conservation. The structure of the syntaxin 6 N-terminal domain shows strong structural similarity with the N-terminal domains of syntaxin 1a, Sso1p, and Vam3p; despite a very low level of sequence similarity. SNARE functions essentially as a tether to hold the vesicle. The cytoplasmic regions of SNARE found on transport vesicles and target membranes interact, then a four-helix coiled coil forms. This links the cell membrane and vesicles together in such a way that it overcomes the energetic barrier to fusing two lipid bilayers. This is the way cell cargo is exchanged. This particular entry focuses on the N-terminal domain of Syntaxin 6.{{cite journal | vauthors = Jung JJ, Inamdar SM, Tiwari A, Choudhury A | title = Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6 | journal = Bioscience Reports | volume = 32 | issue = 4 | pages = 383–91 | date = August 2012 | pmid = 22489884 | pmc = 3392101 | doi = 10.1042/BSR20120006 }}

Members of this entry, which are found in the amino terminus of various SNARE proteins, adopt a structure consisting of an antiparallel three-helix bundle. Their exact function has not been determined, though it is known that they regulate the SNARE motif, as well as mediate various protein-protein interactions involved in membrane-transport.{{cite journal | vauthors = Misura KM, Bock JB, Gonzalez LC, Scheller RH, Weis WI | title = Three-dimensional structure of the amino-terminal domain of syntaxin 6, a SNAP-25 C homolog | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 14 | pages = 9184–9 | date = July 2002 | pmid = 12082176 | pmc = 123115 | doi = 10.1073/pnas.132274599 | doi-access = free }}

SNAREs play a vital role in the trafficking of cell cargo. The vesicles fuse to the cell membrane with the help of SNARE proteins. The SNARE motifs form a four-helix bundle that contributes to the fusion of two membranes. More specifically, the N-terminal domain binds

to the SNARE motif, and this intramolecular interaction decreases the rate of association with the partner SNARE. However the N terminal domain's function still remains to fully elucidated.

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• {{cite journal | vauthors = Wong SH, Xu Y, Zhang T, Griffiths G, Lowe SL, Subramaniam VN, Seow KT, Hong W | display-authors = 6 | title = GS32, a novel Golgi SNARE of 32 kDa, interacts preferentially with syntaxin 6 | journal = Molecular Biology of the Cell | volume = 10 | issue = 1 | pages = 119–34 | date = January 1999 | pmid = 9880331 | pmc = 25158 | doi = 10.1091/mbc.10.1.119 }}
• {{cite journal | vauthors = Steegmaier M, Klumperman J, Foletti DL, Yoo JS, Scheller RH | title = Vesicle-associated membrane protein 4 is implicated in trans-Golgi network vesicle trafficking | journal = Molecular Biology of the Cell | volume = 10 | issue = 6 | pages = 1957–72 | date = June 1999 | pmid = 10359608 | pmc = 25394 | doi = 10.1091/mbc.10.6.1957 }}
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• {{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = October 2000 | doi = 10.1182/blood.V96.7.2574 | pmid = 11001914 }}
• {{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = June 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 | s2cid = 38183181 | url = http://espace.library.uq.edu.au/view/UQ:61103/UQ61103_OA.pdf | doi-access = free }}
• {{cite journal | vauthors = Charest A, Lane K, McMahon K, Housman DE | title = Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29456–65 | date = August 2001 | pmid = 11384996 | doi = 10.1074/jbc.M104137200 | doi-access = free }}
• {{cite journal | vauthors = Rotem-Yehudar R, Galperin E, Horowitz M | title = Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33054–60 | date = August 2001 | pmid = 11423532 | doi = 10.1074/jbc.M009913200 | doi-access = free }}
• {{cite journal | vauthors = Cheng J, Moyer BD, Milewski M, Loffing J, Ikeda M, Mickle JE, Cutting GR, Li M, Stanton BA, Guggino WB | display-authors = 6 | title = A Golgi-associated PDZ domain protein modulates cystic fibrosis transmembrane regulator plasma membrane expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3520–9 | date = February 2002 | pmid = 11707463 | doi = 10.1074/jbc.M110177200 | doi-access = free }}
• {{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | display-authors = 6 | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = February 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}
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• {{cite journal | vauthors = Huynh H, Bottini N, Williams S, Cherepanov V, Musumeci L, Saito K, Bruckner S, Vachon E, Wang X, Kruger J, Chow CW, Pellecchia M, Monosov E, Greer PA, Trimble W, Downey GP, Mustelin T | display-authors = 6 | title = Control of vesicle fusion by a tyrosine phosphatase | journal = Nature Cell Biology | volume = 6 | issue = 9 | pages = 831–9 | date = September 2004 | pmid = 15322554 | doi = 10.1038/ncb1164 | s2cid = 25311826 }}

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• {{UCSC genome browser|STX6}}
• {{UCSC gene details|STX6}}

{{Vesicular transport proteins}}