STX7

{{Short description|Human protein and coding gene}}

{{Infobox_gene}}

Syntaxin-7 is a protein that in humans is encoded by the STX7 gene.{{cite journal | vauthors = Wang H, Frelin L, Pevsner J | title = Human syntaxin 7: a Pep12p/Vps6p homologue implicated in vesicle trafficking to lysosomes | journal = Gene | volume = 199 | issue = 1–2 | pages = 39–48 | date = October 1997 | pmid = 9358037 | doi = 10.1016/S0378-1119(97)00343-0 }}{{cite web | title = Entrez Gene: STX7 syntaxin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8417}}

In melanocytic cells STX7 gene expression may be regulated by MITF.{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell & Melanoma Research | volume = 21 | issue = 6 | pages = 665–76 | date = December 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x | s2cid = 24698373 | doi-access = free }}

Interactions

STX7 has been shown to interact with STX8,{{cite journal | vauthors = Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R | title = A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6453–64 | date = December 2000 | pmid = 11101518 | pmc = 305878 | doi = 10.1093/emboj/19.23.6453 }} VPS18,{{cite journal | vauthors = Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C | title = Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29393–402 | date = August 2001 | pmid = 11382755 | doi = 10.1074/jbc.M101778200 | doi-access = free }} Vesicle-associated membrane protein 8{{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = June 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 | doi-access = free }} and VPS11.

References

{{Reflist}}

Further reading

{{Refbegin | 2}}

  • {{cite journal | vauthors = Wong SH, Xu Y, Zhang T, Hong W | title = Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment | journal = The Journal of Biological Chemistry | volume = 273 | issue = 1 | pages = 375–80 | date = January 1998 | pmid = 9417091 | doi = 10.1074/jbc.273.1.375 | doi-access = free }}
  • {{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34171–9 | date = December 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171 | doi-access = free }}
  • {{cite journal | vauthors = Prekeris R, Yang B, Oorschot V, Klumperman J, Scheller RH | title = Differential roles of syntaxin 7 and syntaxin 8 in endosomal trafficking | journal = Molecular Biology of the Cell | volume = 10 | issue = 11 | pages = 3891–908 | date = November 1999 | pmid = 10564279 | pmc = 25687 | doi = 10.1091/mbc.10.11.3891 }}
  • {{cite journal | vauthors = Nakamura N, Yamamoto A, Wada Y, Futai M | title = Syntaxin 7 mediates endocytic trafficking to late endosomes | journal = The Journal of Biological Chemistry | volume = 275 | issue = 9 | pages = 6523–9 | date = March 2000 | pmid = 10692457 | doi = 10.1074/jbc.275.9.6523 | doi-access = free }}
  • {{cite journal | vauthors = Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH | title = SNAREs contribute to the specificity of membrane fusion | journal = Neuron | volume = 26 | issue = 2 | pages = 457–64 | date = May 2000 | pmid = 10839363 | doi = 10.1016/S0896-6273(00)81177-0 | doi-access = free }}
  • {{cite journal | vauthors = Mullock BM, Smith CW, Ihrke G, Bright NA, Lindsay M, Parkinson EJ, Brooks DA, Parton RG, James DE, Luzio JP, Piper RC | title = Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion | journal = Molecular Biology of the Cell | volume = 11 | issue = 9 | pages = 3137–53 | date = September 2000 | pmid = 10982406 | pmc = 14981 | doi = 10.1091/mbc.11.9.3137 }}
  • {{cite journal | vauthors = Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R | title = A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6453–64 | date = December 2000 | pmid = 11101518 | pmc = 305878 | doi = 10.1093/emboj/19.23.6453 }}
  • {{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = June 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 | doi-access = free }}
  • {{cite journal | vauthors = Kim BY, Krämer H, Yamamoto A, Kominami E, Kohsaka S, Akazawa C | title = Molecular characterization of mammalian homologues of class C Vps proteins that interact with syntaxin-7 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29393–402 | date = August 2001 | pmid = 11382755 | doi = 10.1074/jbc.M101778200 | doi-access = free }}
  • {{cite journal | vauthors = Rotem-Yehudar R, Galperin E, Horowitz M | title = Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29 | journal = The Journal of Biological Chemistry | volume = 276 | issue = 35 | pages = 33054–60 | date = August 2001 | pmid = 11423532 | doi = 10.1074/jbc.M009913200 | doi-access = free }}
  • {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = October 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
  • {{cite journal | vauthors = Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR | title = Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs | journal = Nature Structural Biology | volume = 9 | issue = 2 | pages = 107–11 | date = February 2002 | pmid = 11786915 | doi = 10.1038/nsb746 | hdl = 11858/00-001M-0000-0012-F459-F | s2cid = 17724790 | hdl-access = free }}
  • {{cite journal | vauthors = Antonin W, Dulubova I, Arac D, Pabst S, Plitzner J, Rizo J, Jahn R | title = The N-terminal domains of syntaxin 7 and vti1b form three-helix bundles that differ in their ability to regulate SNARE complex assembly | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36449–56 | date = September 2002 | pmid = 12114520 | doi = 10.1074/jbc.M204369200 | doi-access = free | hdl = 11858/00-001M-0000-0012-F2E6-3 | hdl-access = free }}
  • {{cite journal | vauthors = Bogdanovic A, Bennett N, Kieffer S, Louwagie M, Morio T, Garin J, Satre M, Bruckert F | title = Syntaxin 7, syntaxin 8, Vti1 and VAMP7 (vesicle-associated membrane protein 7) form an active SNARE complex for early macropinocytic compartment fusion in Dictyostelium discoideum | journal = The Biochemical Journal | volume = 368 | issue = Pt 1 | pages = 29–39 | date = November 2002 | pmid = 12175335 | pmc = 1222979 | doi = 10.1042/BJ20020845 }}
  • {{cite journal | vauthors = Collins RF, Schreiber AD, Grinstein S, Trimble WS | title = Syntaxins 13 and 7 function at distinct steps during phagocytosis | journal = Journal of Immunology | volume = 169 | issue = 6 | pages = 3250–6 | date = September 2002 | pmid = 12218144 | doi = 10.4049/jimmunol.169.6.3250 | doi-access = free }}
  • {{cite journal | vauthors = Adkins JN, Varnum SM, Auberry KJ, Moore RJ, Angell NH, Smith RD, Springer DL, Pounds JG | title = Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 12 | pages = 947–55 | date = December 2002 | pmid = 12543931 | doi = 10.1074/mcp.M200066-MCP200 | doi-access = free }}
  • {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
  • {{cite journal | vauthors = Suzuki J, Ohnishi H, Wada A, Hirayama T, Ohno H, Ueda N, Yasuda H, Iiri T, Wada Y, Futai M, Mashima H | title = Involvement of syntaxin 7 in human gastric epithelial cell vacuolation induced by the Helicobacter pylori-produced cytotoxin VacA | journal = The Journal of Biological Chemistry | volume = 278 | issue = 28 | pages = 25585–90 | date = July 2003 | pmid = 12730232 | doi = 10.1074/jbc.M212445200 | doi-access = free }}

{{Refend}}

{{PDB Gallery|geneid=8417}}

{{Vesicular transport proteins}}

{{Gene-6-stub}}