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SUB1

{{cs1 config|name-list-style=vanc}}

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

Activated RNA polymerase II transcriptional coactivator p15 also known as positive cofactor 4 (PC4) or SUB1 homolog is a protein that in humans is encoded by the SUB1 gene.{{cite journal | vauthors = Kretzschmar M, Kaiser K, Lottspeich F, Meisterernst M | title = A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators | journal = Cell | volume = 78 | issue = 3 | pages = 525–534 | date = August 1994 | pmid = 8062392 | doi = 10.1016/0092-8674(94)90429-4 | s2cid = 29077941 }}{{cite journal | vauthors = Ge H, Roeder RG | title = Purification, cloning, and characterization of a human coactivator, PC4, that mediates transcriptional activation of class II genes | journal = Cell | volume = 78 | issue = 3 | pages = 513–523 | date = August 1994 | pmid = 8062391 | doi = 10.1016/0092-8674(94)90428-6 | s2cid = 1140379 }}{{cite web | title = Entrez Gene SUB1: SUB1 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10923}} The human SUB1 gene is named after an orthologous gene in yeast.{{cite journal | vauthors = Knaus R, Pollock R, Guarente L | title = Yeast SUB1 is a suppressor of TFIIB mutations and has homology to the human co-activator PC4 | journal = The EMBO Journal | volume = 15 | issue = 8 | pages = 1933–1940 | date = April 1996 | pmid = 8617240 | pmc = 450112 | doi = 10.1002/j.1460-2075.1996.tb00544.x }}

SUB1 is induced by oxidative stress, and is involved in coordinating cellular responses to DNA strand breaks that arise after oxidative stress.{{cite journal | vauthors = Yu L, Ma H, Ji X, Volkert MR | title = The Sub1 nuclear protein protects DNA from oxidative damage | journal = Molecular and Cellular Biochemistry | volume = 412 | issue = 1–2 | pages = 165–171 | date = January 2016 | pmid = 26708217 | pmc = 5064834 | doi = 10.1007/s11010-015-2621-x }} Yeast SUB1 has structural and functional similarities to human alpha-synuclein, a protein that has an important role in Parkinson's disease.{{cite journal | vauthors = Schaser AJ, Osterberg VR, Dent SE, Stackhouse TL, Wakeham CM, Boutros SW, Weston LJ, Owen N, Weissman TA, Luna E, Raber J, Luk KC, McCullough AK, Woltjer RL, Unni VK | display-authors = 6 | title = Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 10919 | date = July 2019 | pmid = 31358782 | pmc = 6662836 | doi = 10.1038/s41598-019-47227-z }} Like SUB1, alpha-synuclein functions in regulating DNA repair including repair of DNA double-strand breaks.

Interactions

SUB1 has been shown to interact with CSTF2.{{cite journal | vauthors = Calvo O, Manley JL | title = Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination | journal = Molecular Cell | volume = 7 | issue = 5 | pages = 1013–1023 | date = May 2001 | pmid = 11389848 | doi = 10.1016/S1097-2765(01)00236-2 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Kaiser K, Stelzer G, Meisterernst M | title = The coactivator p15 (PC4) initiates transcriptional activation during TFIIA-TFIID-promoter complex formation | journal = The EMBO Journal | volume = 14 | issue = 14 | pages = 3520–3527 | date = July 1995 | pmid = 7628453 | pmc = 394420 | doi = 10.1002/j.1460-2075.1995.tb07358.x }}
  • {{cite journal | vauthors = Ge H, Zhao Y, Chait BT, Roeder RG | title = Phosphorylation negatively regulates the function of coactivator PC4 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 26 | pages = 12691–12695 | date = December 1994 | pmid = 7809103 | pmc = 45505 | doi = 10.1073/pnas.91.26.12691 | doi-access = free }}
  • {{cite journal | vauthors = Brandsen J, Werten S, van der Vliet PC, Meisterernst M, Kroon J, Gros P | title = C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site | journal = Nature Structural Biology | volume = 4 | issue = 11 | pages = 900–903 | date = November 1997 | pmid = 9360603 | doi = 10.1038/nsb1197-900 | s2cid = 30710386 }}
  • {{cite journal | vauthors = Malik S, Guermah M, Roeder RG | title = A dynamic model for PC4 coactivator function in RNA polymerase II transcription | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 5 | pages = 2192–2197 | date = March 1998 | pmid = 9482861 | pmc = 19292 | doi = 10.1073/pnas.95.5.2192 | bibcode = 1998PNAS...95.2192M | doi-access = free }}
  • {{cite journal | vauthors = Luo Y, Ge H, Stevens S, Xiao H, Roeder RG | title = Coactivation by OCA-B: definition of critical regions and synergism with general cofactors | journal = Molecular and Cellular Biology | volume = 18 | issue = 7 | pages = 3803–3810 | date = July 1998 | pmid = 9632764 | pmc = 108964 | doi = 10.1128/mcb.18.7.3803 }}
  • {{cite journal | vauthors = Currie RA | title = Biochemical characterization of the NF-Y transcription factor complex during B lymphocyte development | journal = The Journal of Biological Chemistry | volume = 273 | issue = 29 | pages = 18220–18229 | date = July 1998 | pmid = 9660784 | doi = 10.1074/jbc.273.29.18220 | doi-access = free }}
  • {{cite journal | vauthors = Wang Z, Roeder RG | title = DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III | journal = Molecular Cell | volume = 1 | issue = 5 | pages = 749–757 | date = April 1998 | pmid = 9660958 | doi = 10.1016/S1097-2765(00)80074-X | doi-access = free }}
  • {{cite journal | vauthors = Holloway AF, Occhiodoro F, Mittler G, Meisterernst M, Shannon MF | title = Functional interaction between the HIV transactivator Tat and the transcriptional coactivator PC4 in T cells | journal = The Journal of Biological Chemistry | volume = 275 | issue = 28 | pages = 21668–21677 | date = July 2000 | pmid = 10887206 | doi = 10.1074/jbc.M909058199 | doi-access = free }}
  • {{cite journal | vauthors = Yuan CX, Gurley WB | title = Potential targets for HSF1 within the preinitiation complex | journal = Cell Stress & Chaperones | volume = 5 | issue = 3 | pages = 229–242 | date = July 2000 | pmid = 11005381 | pmc = 312889 }}
  • {{cite journal | vauthors = Kumar BR, Swaminathan V, Banerjee S, Kundu TK | title = p300-mediated acetylation of human transcriptional coactivator PC4 is inhibited by phosphorylation | journal = The Journal of Biological Chemistry | volume = 276 | issue = 20 | pages = 16804–16809 | date = May 2001 | pmid = 11279157 | doi = 10.1074/jbc.M100934200 | doi-access = free }}
  • {{cite journal | vauthors = Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y | display-authors = 6 | title = p15(PAF), a novel PCNA associated factor with increased expression in tumor tissues | journal = Oncogene | volume = 20 | issue = 4 | pages = 484–489 | date = January 2001 | pmid = 11313979 | doi = 10.1038/sj.onc.1204113 | s2cid = 39144360 | doi-access = }}
  • {{cite journal | vauthors = Calvo O, Manley JL | title = Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination | journal = Molecular Cell | volume = 7 | issue = 5 | pages = 1013–1023 | date = May 2001 | pmid = 11389848 | doi = 10.1016/S1097-2765(01)00236-2 | doi-access = free }}
  • {{cite journal | vauthors = Dubois T, Zemlickova E, Howell S, Aitken A | title = Centaurin-alpha 1 associates in vitro and in vivo with nucleolin | journal = Biochemical and Biophysical Research Communications | volume = 301 | issue = 2 | pages = 502–508 | date = February 2003 | pmid = 12565890 | doi = 10.1016/S0006-291X(02)03010-3 }}
  • {{cite journal | vauthors = Fukuda A, Tokonabe S, Hamada M, Matsumoto M, Tsukui T, Nogi Y, Hisatake K | title = Alleviation of PC4-mediated transcriptional repression by the ERCC3 helicase activity of general transcription factor TFIIH | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14827–14831 | date = April 2003 | pmid = 12590132 | doi = 10.1074/jbc.M213172200 | doi-access = free }}
  • {{cite journal | vauthors = Swietlicki E, Iordanov H, Fritsch C, Yi L, Levin MS, Rubin DC | title = Growth factor regulation of PC4/TIS7, an immediate early gene expressed during gut adaptation after resection | journal = Journal of Parenteral and Enteral Nutrition | volume = 27 | issue = 2 | pages = 123–131 | year = 2003 | pmid = 12665168 | doi = 10.1177/0148607103027002123 }}
  • {{cite journal | vauthors = Banerjee S, Kumar BR, Kundu TK | title = General transcriptional coactivator PC4 activates p53 function | journal = Molecular and Cellular Biology | volume = 24 | issue = 5 | pages = 2052–2062 | date = March 2004 | pmid = 14966284 | pmc = 350566 | doi = 10.1128/MCB.24.5.2052-2062.2004 }}
  • {{cite journal | vauthors = Caldwell RB, Braselmann H, Schoetz U, Heuer S, Scherthan H, Zitzelsberger H | title = Positive Cofactor 4 (PC4) is critical for DNA repair pathway re-routing in DT40 cells | journal = Scientific Reports | volume = 6 | pages = 28890 | date = July 2016 | pmid = 27374870 | pmc = 4931448 | doi = 10.1038/srep28890 | bibcode = 2016NatSR...628890C }}

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External links

  • {{PDBe-KB2|P53999|Activated RNA polymerase II transcriptional coactivator p15}}

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