SUGT1

{{Short description|Human protein and coding gene}}

{{Infobox_gene}}

Suppressor of G2 allele of SKP1 homolog is a protein that in humans is encoded by the SUGT1 gene.{{cite journal | vauthors = Kitagawa K, Skowyra D, Elledge SJ, Harper JW, Hieter P | title = SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex | journal = Molecular Cell | volume = 4 | issue = 1 | pages = 21–33 | date = July 1999 | pmid = 10445024 | doi = 10.1016/S1097-2765(00)80184-7 | doi-access = free }}{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}

Function

This gene is homologous to the yeast gene SGT1, which encodes a protein involved in kinetochore function and required for the G1/S and G2/M transitions. Complementation studies suggest that the human protein has similar functions.{{cite web | title = Entrez Gene: SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10910}}

Interactions

SUGT1 has been shown to interact with S100A6.{{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}

References

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Further reading

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  • {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 | s2cid = 23783563 }}
  • {{cite journal | vauthors = Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J | title = Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins | journal = The Journal of Biological Chemistry | volume = 278 | issue = 29 | pages = 26923–8 | date = July 2003 | pmid = 12746458 | doi = 10.1074/jbc.M211518200 | doi-access = free }}
  • {{cite journal | vauthors = Niikura Y, Kitagawa K | title = Identification of a novel splice variant: human SGT1B (SUGT1B) | journal = DNA Sequence | volume = 14 | issue = 6 | pages = 436–41 | date = December 2003 | pmid = 15018354 | doi = 10.1080/10425170310001623644 | s2cid = 20578581 }}
  • {{cite journal | vauthors = Zou X, Ji C, Wang L, Wu M, Zheng H, Xu J, Jin F, Gu S, Ying K, Xie Y, Mao Y | title = Molecular cloning and characterization of SGT1.2, a novel splice variant of Homo sapiens SGT1 | journal = DNA Sequence | volume = 15 | issue = 2 | pages = 140–3 | date = April 2004 | pmid = 15346769 | doi = 10.1080/1042517032000160215 | s2cid = 37324928 }}
  • {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells | journal = Nature Biotechnology | volume = 23 | issue = 1 | pages = 94–101 | date = January 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 | s2cid = 7200157 }}
  • {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = October 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 | s2cid = 14294292 }}
  • {{cite journal | vauthors = da Silva Correia J, Miranda Y, Leonard N, Ulevitch R | title = SGT1 is essential for Nod1 activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 16 | pages = 6764–9 | date = April 2007 | pmid = 17420470 | pmc = 1871859 | doi = 10.1073/pnas.0610926104 | bibcode = 2007PNAS..104.6764D | doi-access = free }}
  • {{cite journal | vauthors = Spiechowicz M, Zylicz A, Bieganowski P, Kuznicki J, Filipek A | title = Hsp70 is a new target of Sgt1--an interaction modulated by S100A6 | journal = Biochemical and Biophysical Research Communications | volume = 357 | issue = 4 | pages = 1148–53 | date = June 2007 | pmid = 17466273 | doi = 10.1016/j.bbrc.2007.04.073 }}

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