SULF2
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.{{cite journal | vauthors = Morimoto-Tomita M, Uchimura K, Werb Z, Hemmerich S, Rosen SD | title = Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humans | journal = The Journal of Biological Chemistry | volume = 277 | issue = 51 | pages = 49175–49185 | date = December 2002 | pmid = 12368295 | pmc = 2779716 | doi = 10.1074/jbc.M205131200 | doi-access = free }}{{cite web | title = Entrez Gene: SULF2 sulfatase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55959| accessdate = }}
Function
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]
References
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Further reading
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- {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Research | volume = 9 | issue = 3 | pages = 99–106 | date = June 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 | citeseerx = 10.1.1.500.923 }}
- {{cite journal | vauthors = Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 6 | issue = 5 | pages = 337–345 | date = October 1999 | pmid = 10574462 | doi = 10.1093/dnares/6.5.337 | doi-access = free }}
- {{cite journal | vauthors = Fossey SC, Mychaleckyj JC, Pendleton JK, Snyder JR, Bensen JT, Hirakawa S, Rich SS, Freedman BI, Bowden DW | title = A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 | journal = Genomics | volume = 76 | issue = 1–3 | pages = 45–57 | date = August 2001 | pmid = 11549316 | doi = 10.1006/geno.2001.6584 }}
- {{cite journal | vauthors = Dai Y, Yang Y, MacLeod V, Yue X, Rapraeger AC, Shriver Z, Venkataraman G, Sasisekharan R, Sanderson RD | title = HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo | journal = The Journal of Biological Chemistry | volume = 280 | issue = 48 | pages = 40066–40073 | date = December 2005 | pmid = 16192265 | doi = 10.1074/jbc.M508136200 | doi-access = free }}
- {{cite journal | vauthors = Morimoto-Tomita M, Uchimura K, Bistrup A, Lum DH, Egeblad M, Boudreau N, Werb Z, Rosen SD | title = Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer | journal = Neoplasia | volume = 7 | issue = 11 | pages = 1001–1010 | date = November 2005 | pmid = 16331886 | pmc = 1502017 | doi = 10.1593/neo.05496 }}
- {{cite journal | vauthors = Uchimura K, Morimoto-Tomita M, Bistrup A, Li J, Lyon M, Gallagher J, Werb Z, Rosen SD | title = HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1 | journal = BMC Biochemistry | volume = 7 | pages = 2 | year = 2006 | pmid = 16417632 | pmc = 1386684 | doi = 10.1186/1471-2091-7-2 | doi-access = free }}
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Category:Extracellular matrix remodeling enzymes
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