SULT4A1

{{Short description|Protein-coding gene in the species Homo sapiens}}

Sulfotransferase 4A1 is an enzyme that in humans is encoded by the SULT4A1 gene.{{cite journal | vauthors = Falany CN, Xie X, Wang J, Ferrer J, Falany JL | title = Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain | series = 346 | journal = Biochem J | volume = Pt 3 | pages = 857–64 |date=May 2000 | issue = 3 | doi = 10.1042/bj3460857 | pmid = 10698717 | pmc = 1220923 }}{{cite web | title = Entrez Gene: SULT4A1 sulfotransferase family 4A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25830}}

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia.

References

{{cite journal |vauthors=Weinshilboum RM, Otterness DM, Aksoy IA, etal |title=Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. |journal=FASEB J. |volume=11 |issue= 1 |pages= 3–14 |year= 1997 |pmid= 9034160 |doi= 10.1096/fasebj.11.1.9034160|doi-access=free |s2cid=3977677 }}
{{cite journal |vauthors=Glatt H, Engelke CE, Pabel U, etal |title=Sulfotransferases: genetics and role in toxicology. |journal=Toxicol. Lett. |volume=112–113 |issue= 1–3|pages= 341–8 |year= 2000 |pmid= 10720750 |doi=10.1016/S0378-4274(99)00214-3 }}
{{cite journal | author=Glatt H |title=Sulfotransferases in the bioactivation of xenobiotics. |journal=Chem. Biol. Interact. |volume=129 |issue= 1–2 |pages= 141–70 |year= 2001 |pmid= 11154739 |doi=10.1016/S0009-2797(00)00202-7 |bibcode=2000CBI...129..141G }}
{{cite journal |vauthors=Glatt H, Boeing H, Engelke CE, etal |title=Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects. |journal=Mutat. Res. |volume=482 |issue= 1–2 |pages= 27–40 |year= 2001 |pmid= 11535246 |doi=10.1016/S0027-5107(01)00207-X }}
{{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 |bibcode=1999Natur.402..489D |doi-access= free }}
{{cite journal |vauthors=Sakakibara Y, Suiko M, Pai TG, etal |title=Highly conserved mouse and human brain sulfotransferases: molecular cloning, expression, and functional characterization. |journal=Gene |volume=285 |issue= 1–2 |pages= 39–47 |year= 2002 |pmid= 12039030 |doi=10.1016/S0378-1119(02)00431-6 }}
{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
{{cite journal |vauthors=Collins JE, Goward ME, Cole CG, etal |title=Reevaluating human gene annotation: a second-generation analysis of chromosome 22. |journal=Genome Res. |volume=13 |issue= 1 |pages= 27–36 |year= 2003 |pmid= 12529303 |doi= 10.1101/gr.695703 | pmc=430954 }}
{{cite journal |vauthors=Liyou NE, Buller KM, Tresillian MJ, etal |title=Localization of a brain sulfotransferase, SULT4A1, in the human and rat brain: an immunohistochemical study. |journal=J. Histochem. Cytochem. |volume=51 |issue= 12 |pages= 1655–64 |year= 2004 |pmid= 14623933 |doi= 10.1177/002215540305101209|doi-access=free }}
{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 |doi-access=free }}
{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{cite journal | vauthors=Brennan MD, Condra J |title=Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=139 |issue= 1 |pages= 69–72 |year= 2006 |pmid= 16152568 |doi= 10.1002/ajmg.b.30222 |s2cid=8927459 }}
{{cite journal |vauthors=Allali-Hassani A, Pan PW, Dombrovski L, etal |title=Structural and chemical profiling of the human cytosolic sulfotransferases. |journal=PLOS Biol. |volume=5 |issue= 5 |pages= e97 |year= 2007 |pmid= 17425406 |doi= 10.1371/journal.pbio.0050097 | pmc=1847840 |doi-access=free }}

SULT4A1

References

Further reading