SYT6
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
Synaptotagmin-6 is a protein that in humans is encoded by the SYT6 gene.{{cite journal | vauthors = Craxton M | title = Genomic analysis of synaptotagmin genes | journal = Genomics | volume = 77 | issue = 1–2 | pages = 43–9 | date = September 2001 | pmid = 11543631 | doi = 10.1006/geno.2001.6619 }}{{cite web | title = Entrez Gene: SYT6 synaptotagmin VI| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=148281}}
Function
Synaptotagmins, such as SYT6, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM]
References
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Further reading
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- {{cite journal | vauthors = Roggero CM, Tomes CN, De Blas GA, Castillo J, Michaut MA, Fukuda M, Mayorga LS | title = Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis | journal = Developmental Biology | volume = 285 | issue = 2 | pages = 422–35 | date = September 2005 | pmid = 16111671 | doi = 10.1016/j.ydbio.2005.07.007 | doi-access = free }}
- {{cite journal | vauthors = Michaut M, De Blas G, Tomes CN, Yunes R, Fukuda M, Mayorga LS | title = Synaptotagmin VI participates in the acrosome reaction of human spermatozoa | journal = Developmental Biology | volume = 235 | issue = 2 | pages = 521–9 | date = July 2001 | pmid = 11437455 | doi = 10.1006/dbio.2001.0316 | doi-access = free }}
- {{cite journal | vauthors = Perin MS | title = Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin | journal = Biochemistry | volume = 35 | issue = 43 | pages = 13808–16 | date = October 1996 | pmid = 8901523 | doi = 10.1021/bi960853x }}
- {{cite journal | vauthors = Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC | title = Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins | journal = Nature | volume = 375 | issue = 6532 | pages = 594–9 | date = June 1995 | pmid = 7791877 | doi = 10.1038/375594a0 | bibcode = 1995Natur.375..594L | s2cid = 4265549 }}
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{{Vesicular transport proteins}}