SYT7

Synaptotagmins, such as SYT7, are calcium-dependent phospholipid-binding proteins known for their role in synaptic exocytosis and neurotransmitter release. Significant expression has also been observed in the prostate and other tissues. See MIM 600782 [supplied by OMIM]

SYT7 has been shown to interact with SYNCRIP.{{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = March 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 | doi-access = free }}

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• {{cite journal | vauthors = Li C, Ullrich B, Zhang JZ, Anderson RG, Brose N, Südhof TC | title = Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins | journal = Nature | volume = 375 | issue = 6532 | pages = 594–9 | date = June 1995 | pmid = 7791877 | doi = 10.1038/375594a0 | bibcode = 1995Natur.375..594L | s2cid = 4265549 }}
• {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 | doi-access = free }}
• {{cite journal | vauthors = Perin MS | title = Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin | journal = Biochemistry | volume = 35 | issue = 43 | pages = 13808–16 | date = October 1996 | pmid = 8901523 | doi = 10.1021/bi960853x }}
• {{cite journal | vauthors = Craxton M, Goedert M | title = Alternative splicing of synaptotagmins involving transmembrane exon skipping | journal = FEBS Letters | volume = 460 | issue = 3 | pages = 417–22 | date = November 1999 | pmid = 10556508 | doi = 10.1016/S0014-5793(99)01382-4 | s2cid = 19207631 | doi-access = free | bibcode = 1999FEBSL.460..417C }}
• {{cite journal | vauthors = Walker MG, Volkmuth W, Sprinzak E, Hodgson D, Klingler T | title = Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes | journal = Genome Research | volume = 9 | issue = 12 | pages = 1198–203 | date = December 1999 | pmid = 10613842 | pmc = 310991 | doi = 10.1101/gr.9.12.1198 }}
• {{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = March 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 | doi-access = free }}
• {{cite journal | vauthors = Caler EV, Chakrabarti S, Fowler KT, Rao S, Andrews NW | title = The Exocytosis-regulatory protein synaptotagmin VII mediates cell invasion by Trypanosoma cruzi | journal = The Journal of Experimental Medicine | volume = 193 | issue = 9 | pages = 1097–104 | date = May 2001 | pmid = 11342594 | pmc = 2193425 | doi = 10.1084/jem.193.9.1097 }}
• {{cite journal | vauthors = Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K | title = Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human | journal = The Biochemical Journal | volume = 365 | issue = Pt 1 | pages = 173–80 | date = July 2002 | pmid = 12071850 | pmc = 1222667 | doi = 10.1042/BJ20011877 }}

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• {{PDBe-KB2|O43581|Human Synaptotagmin-7}}
• {{PDBe-KB2|Q9R0N7|Mouse Synaptotagmin-7}}

{{PDB Gallery|geneid=9066}}

{{Vesicular transport proteins}}

{{gene-11-stub}}