Sainte-Mesme

{{Infobox French commune

|name = Sainte-Mesme

|commune status = Commune

|arrondissement = Rambouillet

|canton = Rambouillet

|INSEE = 78569

|postal code = 78730

|mayor = Isabelle Copetti{{cite web|title=Répertoire national des élus: les maires|url=https://www.data.gouv.fr/fr/datasets/r/2876a346-d50c-4911-934e-19ee07b0e503|publisher=data.gouv.fr, Plateforme ouverte des données publiques françaises|date=4 May 2022|language=fr}}

|term = 2020–2026

|intercommunality = CA Rambouillet Territoires

|coordinates = {{coord|48.5314|1.9594|format=dms|display=inline,title}}

|elevation m = 117

|elevation min m = 96

|elevation max m = 162

|area km2 = 8.16

|population = {{France metadata Wikidata|population_total}}

|population date = {{France metadata Wikidata|population_as_of}}

|population footnotes = {{France metadata Wikidata|population_footnotes}}

}}

Sainte-Mesme ({{IPA|fr|sɛ̃t mɛm}}) is a commune in the Yvelines department in the Île-de-France region in north-central France.