Samuel Gan

Samuel Ken-En Gan graduated from Temasek Polytechnic{{cite web |title=Temasek Polytechnic: Bringing Education to Life and Life to Education |url=https://www.tp.edu.sg/}} with a Diploma in Biotechnology. He attained his BSc (Hons) in Molecular Cell Biology from University College London{{cite web |title=UCL - London's Global University |url=https://www.ucl.ac.uk/}} before embarking on his Masters in Structural Biology from Birkbeck College{{cite web |title=Home — Birkbeck, University of London |url=http://www.bbk.ac.uk/}} and Ph.D. in Allergy from King's College London{{cite web |title=King's College London |url=https://www.kcl.ac.uk}} simultaneously with his BSc (Hons) in Psychology from Open University,{{cite web |title=The Open University: Distance Learning Courses and Adult ... |url=http://www.open.ac.uk/}} Graduate Certificate in Academic Practice and the Associate of King’s College, both from King’s College London.

Gan is also trained in translation & interpretation, theology, business admin, and commercial law & tech transfer. He is a member of the Higher Education Academy UK, the British Psychological Society, Biochemical Society UK, Allergy & Clinical Immunology Society Singapore, and the New York Academy of Sciences.

Samuel Ken-En Gan performs and publishes research articles in many disciplines.

He currently has over 90 publications{{cite web |title=About - APD SKEG Pte Ltd |website=Facebook|url=https://www.facebook.com/pg/APDLab/about/}} that includes scientific research articles and books spanning over antibody engineering, viral mutations, psychology (including music psychology), theology, apologetics, scientific phone apps, and science-fiction.

He is most well-known publicly for being one of the pioneers of scientific phone apps,{{cite web |title=Scientific recognition for mobile app developers - A*STAR Research |url=https://research.a-star.edu.sg/articles/features/scientific-recognition-for-mobile-app-developers/}}{{cite web |title=Counting microbes on a smartphone |url=https://research.a-star.edu.sg/articles/highlights/counting-microbes-on-a-smartphone/}}{{cite journal |last1=Sim |first1=Jia-Zhi |last2=Nguyen |first2=Phi-Vu |last3=Su |first3=Chinh Tran-To |last4=Gan |first4=Samuel Ken-En |title=The Rise of the Mobile Lab the Use of Smartphone Apps for Biomedical Research |journal=Asia Pacific Biotech News |date=2015 |volume=19 |issue=3|doi=10.1142/S021903031500021X |url=https://www.asiabiotech.com/articles/content/vol19/1903.html}}{{cite journal |last1=Nguyen |first1=Phi-Vu |last2=Ghezal |first2=Ali |last3=Hsueh |first3=Ya-Chih |last4=Thomas |first4=Boudier |last5=Gan |first5=Samuel Ken-En |last6=Lim |first6=Hwee Kuan |title=Optimal processing for gel electrophoresis images: Applying Monte Carlo Tree Search in GelApp |journal=Electrophoresis |date=2016 |volume=37 |issue=15–16 |pages=2208–2216 |doi=10.1002/elps.201600197 |pmid=27251892 |s2cid=6446229 }}{{cite web |title=Android app to enhance a DNA sequencing through image processsing algorithm |url=https://www.peerscientist.com/android-app-to-enhance-a-dna-sequencing-through-image-processsing-algorithm/ |archive-url=https://web.archive.org/web/20170728160209/https://www.peerscientist.com/android-app-to-enhance-a-dna-sequencing-through-image-processsing-algorithm/ |url-status=dead |archive-date=2017-07-28 |access-date=2017-07-28 }}{{cite web |title=Scientists use a gaming algorithm to enhance a DNA sequencing Android app |url=https://www.longroom.com/discussion/285675/scientists-use-a-gaming-algorithm-to-enhance-a-dna-sequencing-android-app}}{{cite web |title=Exploring open access publishing in Asia with Samuel Gan from Scientific Phone Apps and Mobile Devices |date=13 December 2016|url=http://blogs.springeropen.com/springeropen/2016/12/13/exploring-open-access-publishing-in-asia-with-samuel-gan-from-scientific-phone-apps-and-mobile-devices/}} in particularly, DNAApp,{{cite journal |last1=Nguyen |first1=Phi-Vu |last2=Verma |first2=Chandra Shekhar |last3=Gan |first3=Samuel Ken-En |title=DNAApp: a mobile application for sequencing data analysis |journal=Bioinformatics |date=2015 |volume=30 |issue=22 |pages=3270–3271 |doi=10.1093/bioinformatics/btu525 |pmid=25095882 |pmc=4221124 |url=https://academic.oup.com/bioinformatics/article/30/22/3270/2391041|doi-access=free }} which received significant worldwide coverage{{cite web |title=Pocket Science: New Mobile Application Enables DNA Analysis On The Go |url=https://sg.finance.yahoo.com/news/pocket-science-mobile-application-enables-074400164.html}}{{cite web |title=Setting sequencing free - A*STAR Research|url=https://research.a-star.edu.sg/articles/features/setting-sequencing-free/}}{{cite web |title=DNAApp - Best Science Apps |date=28 April 2017|url=https://www.genengnews.com/resources/dnaapp/}}{{cite web |title=New mobile application enables DNA analysis on the go |url=https://phys.org/news/2014-05-mobile-application-enables-dna-analysis.html}}{{cite web |title=DNA analysis in the pocket! |url=https://www.biospectrumasia.com/influencers/54/6589/dna-analysis-in-the-pocket.html}} and started the work of scientific phone apps, including founding the journal with SpringerNature. Gan also has research in psychology, particularly in the context of Singapore. His most noted work in this discipline is the ‘P2P’ theory on how music can moderate anxiety and affect learning.{{cite journal |last1=Gan |first1=Samuel Ken-En |last2=Lim |first2=Keane Ming-Jie |last3=Haw |first3=Yu-Xuan |title=The relaxation effects of stimulative and sedative music on mathematics anxiety: A perception to physiology model |journal=Psychology of Music |date=2015 |volume=44 |issue=4 |pages=730–741 |doi=10.1177/0305735615590430 |s2cid=147562408 }} Combining psychology and apps, his lab now has research in psychological game apps to validate and study psychological parameters via smartphone game apps.{{cite journal |last1=Gan |first1=Samuel Ken-En |last2=Yeo |first2=Joshua Yi |title=Editorial: The promises of Microcontroller kits and Smartphone apps for Psychological research |journal=Scientific Phone Apps and Mobile Devices |date=2020 |volume=6 |issue=2 |page=https://scientificarticles.apdskeg.com/Articles2020/promisesOfMicrocontrollerKitsAndSmartphoneAppsForPsychologicalResearch.html |doi=10.30943/2020/06022020|doi-access=free }}

In biomedical sciences, Gan’s research publications are focused on holistic protein engineering,{{cite journal |last1=Phua |first1=Ser-Xian |last2=Chan |first2=Kwok-Fong |last3=Su |first3=Chinh Tran-To |last4=Poh |first4=Jun-Jie |last5=Gan |first5=Samuel Ken-En |title=Perspective: The promises of a holistic view of proteins—impact on antibody engineering and drug discovery |journal=Bioscience Reports |date=2019 |volume=39 |issue=1 |doi=10.1042/BSR20181958 |pmid=30630879 |pmc=6398899 }} particularly in the rational drug design of antibody therapeutics.{{cite journal |last1=Ling |first1=Wei-Li |last2=Lua |first2=Wai-Heng |last3=Poh |first3=Jun-Jie |last4=Yeo |first4=Joshua Yi |last5=Lane |first5=David Philip |last6=Gan |first6=Samuel Ken-En |title=Effect of VH–VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding |journal=Frontiers in Immunology |date=2018 |volume=9 |page=469 |doi=10.3389/fimmu.2018.00469 |pmid=29593727 |pmc=5857972 |doi-access=free }}{{cite journal |last1=Lua |first1=Wai-Heng |last2=Ling |first2=Wei-Li |last3=Yeo |first3=Joshua Yi |last4=Poh |first4=Jun-Jie |last5=Lane |first5=David Philip |last6=Gan |first6=Samuel Ken-En |title=The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding |journal=Scientific |date=2018 |volume=8 |issue=1 |pages=718 |doi=10.1038/s41598-017-18892-9 |pmid=29335579 |pmc=5768722 |bibcode=2018NatSR...8..718L }}{{cite journal |last1=Su |first1=Chinh Tran-To |last2=Ling |first2=Wei-Li |last3=Lua |first3=Wai-Heng |last4=Poh |first4=Jun-Jie |last5=Gan |first5=Samuel Ken-En |title=The role of Antibody Vκ Framework 3 region towards Antigen binding: Effects on recombinant production and Protein L binding |journal=Scientific Reports |date=2017 |volume=7 |issue=1 |page=3766 |doi=10.1038/s41598-017-02756-3 |pmid=28630463 |pmc=5476676 |bibcode=2017NatSR...7.3766S |doi-access=free }}{{cite journal |last1=Lua |first1=Wai-Heng |last2=Su |first2=Chinh Tran-To |last3=Yeo |first3=Joshua Yi |last4=Poh |first4=Jun-Jie |last5=Ling |first5=Wei-Li |last6=Gan |first6=Samuel Ken-En |title=Role of the IgE variable heavy chain in FcεRIα and superantigen binding in allergy and immunotherapy |journal=Journal of Allergy and Clinical Immunology |date=2019 |volume=144 |issue=2 |pages=514–523.e5 |doi=10.1016/j.jaci.2019.03.028|pmid=30995457 |doi-access=free }}{{cite journal |last1=Su |first1=Chinh Tran-To |last2=Lua |first2=Wai-Heng |last3=Ling |first3=Wei-Li |last4=Gan |first4=Samuel Ken-En |title=Allosteric Effects between the Antibody Constant and Variable Regions: A Study of IgA Fc Mutations on Antigen Binding |journal=Antibodies |date=2018 |volume=7 |issue=20 |pages=20 |doi=10.3390/antib7020020 |pmid=31544872 |pmc=6698812 |doi-access=free }}{{cite journal |last1=Samsudin |first1=Firdaus |last2=Yeo |first2=Joshua Yi |last3=Gan |first3=Samuel Ken-En |last4=Bond |first4=Peter J |title=Not all therapeutic antibody isotypes are equal: the case of IgM versus IgG in Pertuzumab and Trastuzumab |journal=Chemical Science |date=2020 |volume=11 |issue=10 |pages=2843–2854 |doi=10.1039/C9SC04722K |pmid=32206268 |pmc=7069520 |doi-access=free }} In the area of viruses, his work focusses on understanding protein-protein interactions in HIV drug targets, and how new interventions can be designed.{{cite journal |last1=Su |first1=Chinh Tran-To |last2=Kwoh |first2=Chee-Keong |last3=Verma |first3=Chandra Shekhar |last4=Gan |first4=Samuel Ken-En |title=Modeling the full length HIV-1 Gag polyprotein reveals the role of its p6 subunit in viral maturation and the effect of non-cleavage site mutations in protease drug resistance |journal=Journal of Biomolecular Structure and Dynamics |date=2017 |volume=36 |issue=16 |pages=4366–4377 |doi=10.1080/07391102.2017.1417160 |pmid=29237328 |s2cid=45224066 }}{{cite journal |last1=Chiang |first1=Ron Zhi-Hui |last2=Su |first2=Chinh Tran-To |last3=Gan |first3=Samuel Ken-En |title=A computational study for rational HIV-1 non-nucleoside reverse transcriptase inhibitor selection and the discovery of novel allosteric pockets for inhibitor design |journal=Bioscience Reports |date=2018 |volume=38 |issue=2 |doi=10.1042/BSR20171113 |pmid=29437904 |pmc=5835713 }}{{cite journal |last1=Su |first1=Chinh Tran-To |last2=Ling |first2=Wei-Li |last3=Lua |first3=Wai-Heng |last4=Haw |first4=Yu-Xuan |last5=Gan |first5=Samuel Ken-En |title=Structural analyses of 2015-updated drug-resistant mutations in HIV-1 protease: an implication of protease inhibitor cross-resistance |journal=BMC Bioinformatics |date=2016 |volume=17 |issue=Suppl 19 |page=500 |doi=10.1186/s12859-016-1372-3 |pmid=28155724 |pmc=5259968 |doi-access=free }}{{cite journal |last1=Su |first1=Chinh Tran-To |last2=Koh |first2=Darius Wen-Shuo |last3=Gan |first3=Samuel Ken-En |title=Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs |journal=Molecules |date=2019 |volume=24 |issue=18 |pages=3243 |doi=10.3390/molecules24183243 |pmid=31489889 |pmc=6767625 |doi-access=free }}{{cite journal |last1=Chan |first1=Kwok-Fong |last2=Phua |first2=Ser-Xian |last3=Su |first3=Chinh Tran-To |last4=Gan |first4=Samuel Ken-En |title=Inhibiting HIV-1 and MMLV Reverse Transcriptase: The potential of an Allosteric Broad-Spectrum Inhibitor |journal=bioRxiv |date=2019 |page=699470 |doi=10.1101/699470 |url=https://www.biorxiv.org/content/10.1101/699470v1|doi-access=free }}

Gan plays a significant role in mentoring and coaching polytechnic students across multiple disciplines in Singapore to publish in international journals and develop products. For his effort, he was featured on a report by Temasek Polytechnic to the Parliament of Singapore{{cite web |title=Rediscovering Classrooms - Annual Report 2014/15 - Temasek Polytechnic |url=https://www.tp.edu.sg/about-tp/media-centre/annual-reports/2014-15/rediscovering}} and on a number of news articles.{{cite web |title=TP student helps advance HIV research during internship |date=11 June 2018|url=https://tnp.straitstimes.com/news/singapore/tp-student-helps-advance-hiv-research-during-internship}}{{cite web |title=Temasek Polytechnic final-year students showcase innovative apps |date=25 March 2019|url=https://tnp.straitstimes.com/news/singapore/temasek-polytechnic-final-year-students-showcase-innovative-apps}}{{cite web |title=It's kind of fun to do the impossible. - Temasek Polytechnic |url=https://www.tp.edu.sg/about-tp/media-centre/blog-articles/its-kind-of-fun-to-do-the-impossible}}

According to his lab social media page, more than 170 interns and tertiary students have been trained since 2013, along with the development of courses with institutions of learning in Singapore.{{cite web |title=Specialist Diploma in Biomedical Informatics and Analytics - Republic Polytechnic |url=https://www.rp.edu.sg/ace/course-summary/Detail/specialist-diploma-in-biomedical-informatics-and-analytics}}{{cite web |title=Registration for the "Introductory Bioinformatics Workshop" Commencement in July 2018 is now ready! |website=Facebook|url=https://www.facebook.com/APDLab/posts/2011940639065839}}

In 2006, Gan was featured as one of the 100 most talented Singaporeans below the age of 25{{cite web |title=2006, Straits Times Newspaper, Dr Gan was featured as the top 100 Singaporeans under the age of 25 |website = Facebook|url=https://www.facebook.com/APDLab/photos/ms.c.eJxFjtENREEIAju6iK669N~;YZTX6ficwAGrAmTgGcfKHB0I8Mo7dkw2cpDBT7Q4IvkoIFvircBIh4iUNn0SiE7qgVqi7ktk~;bAEb7Mr1~_uHrYEvxAW2A~_QGpyqyEwErq~_QfUTjO9.bps.a.1926159647643939/1926159774310593/?type=3&theater}} and one of 200 selected international students globally for the 7th China Synergy Programme for Outstanding Youths 第七届海外杰青会.{{cite web |title=China Synergy Programme for Our Outstanding Youth (CSP) |url=http://www.chinasynergy.org.hk/}}

Gan was listed as one of fifty skilled talented alumni from polytechnic/ITE in Singapore in the SG50 Book “A Nation of Skilled Talents”,{{cite web |title=A Nation of Skilled Talents - SG50 |website=Facebook|url=https://www.facebook.com/sg50book/}} selected as one of the “world’s most promising researchers” in the Interstellar Initiative by the New York Academy of Sciences and the Japan Agency for Medical Research and Development, as well as one of the 30 world class innovators{{cite web |title=Innovator-Entrepreneurs: The Passionate, Compassionate, and Grumpy |date=6 September 2017|url=https://medium.com/@Dr.CJ/innovator-entrepreneurs-the-passionate-compassionate-and-grumpy-7a54891018ce}}{{cite web |title=Fusion 20 - Set My Scientists Free |website = YouTube| date=24 May 2018 |url=https://www.youtube.com/watch?v=S-G3SpZOdeM&feature=emb_logo}} in the book “Innovation Through Fusion” by Dr CJ Meadows.{{cite book |last1=CJ |first1=Meadows |title=Innovation through Fusion: Combining Innovative Ideas to Create High Impact Solutions |date=2020 |publisher=Walter de Gruyter GmbH & Co KG |isbn=9781547401543}} In late 2020, Gan's team won Bronze in the inaugural Merck Lab Connectivity Challenge internationally {{Cite web|url=https://www.merckgroup.com/en/research/open-innovation/2020-research-challenges/connectivity-challenge.html|title = Connectivity Challenge - Research | Merck KGaA, Darmstadt, Germany | Merck KGaA, Darmstadt, Germany}} for their work on scientific phone apps and prototype devices. In Feb 2022, Gan was named winner of the "Science and Sustainability" category in the UK Alumni Awards 2021-22 in Singapore.{{Cite web |last=British Council |date=23 Feb 2022 |title=British Council announces winners of inaugural Study UK Alumni Awards |url=https://www.britishcouncil.sg/about/press/british-council-announces-winners-inaugural-study-uk-alumni-awards |website=British Council}}

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Category:1981 births

Category:Living people

Category:Alumni of King's College London

Category:Singaporean people of Chinese descent

Category:Singaporean educators

Category:Singaporean writers