Santa Cruz Amilpas
{{Infobox settlement
|name = Santa Cruz Amilpas
|settlement_type =Municipality and town
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|map_caption = Location of the municipality in Oaxaca
|pushpin_map = Mexico
|pushpin_label_position =above
|pushpin_mapsize =300
|pushpin_map_caption =Location in Mexico
|subdivision_type = Country
|subdivision_name = {{flag|Mexico}}
|subdivision_type1 = State
|subdivision_name1 = Oaxaca
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|timezone = Central Standard Time
|utc_offset = -6
|timezone_DST = Central Daylight Time
|utc_offset_DST = -5
|coordinates = {{coord|17|4|N|96|41|W|source:eowiki_region:MX|display=it}}
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|website = [http://santacruzamilpas.com/ http://www.santacruzamilpas.com]
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Santa Cruz Amilpas is a town and municipality in Oaxaca in southeastern Mexico and is the second smallest municipality in Oaxaca, only being bigger than Natividad. However, it is also the most densely populated municipality in Oaxaca. The municipality covers an area of 2.27 km².{{Cite web|url=http://www.inafed.gob.mx/work/enciclopedia/EMM20oaxaca/municipios/20375a.html|title=Enciclopedia de los municipios y delegaciones de México}}
It is part of the Centro District in the Valles Centrales region.
In 2010, the municipality had a population of 10,120.{{Cite web|url=https://www.gob.mx/cms/uploads/attachment/file/48211/Oaxaca_375.pdf|title=Informe anual sobre la situación de pobreza y rezago soical}}