Santa Cruz Tacache de Mina

{{Infobox settlement

|name = Santa Cruz Tacache de Mina

|settlement_type =Municipality and town

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|map_caption = Location of the municipality in Oaxaca

|pushpin_map = Mexico

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|subdivision_name = {{flag|Mexico}}

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|subdivision_name1 = Oaxaca

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|timezone = Central Standard Time

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Santa Cruz Tacache de Mina is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km².

It is part of the Huajuapan District in the north of the Mixteca Region.

In 2020, the town had a total population of 2,940, growing 12.8% from 2010.{{Cite web |title=Santa Cruz Tacache de Mina: Economía, empleo, equidad, calidad de vida, educación, salud y seguridad pública |url=https://datamexico.org/es/profile/geo/santa-cruz-tacache-de-mina |access-date=2022-11-22 |website=Data México |language=es}}