Santa Fe derby

{{Infobox sports rivalry

| wide = 250

| name = Santa Fe derby

| native_name = Clásico Santafesino

| other_names =

| image =

| image_size =

| caption =

| team1logo = Escudo_del_Club_Atlético_Colón.png

| team2logo = Escudo_del_Club_Atlético_Unión.svg

| team1 = Colón

| team2 = Unión

| sport = Association football

| city or region = Santa Fe, Argentina

| firstmeeting = 30 March 1913
Friendly match
Unión 2–3 Colón

| mostrecent = 1 October 2023
2023 Copa de la Liga Profesional
Colón 0–0 Unión

| most wins = Unión (57)

| most player appearances = Aniceto Roldán (15)

| top scorer = Francisco Valiente (14)

| nextmeeting =

| total = 159 {{refn|Include league and cup matches.|group=note|name=includ}}

| league =

| series = Unión: 57
Colón: 48
Draws: 54

| regularseason =

| postseason =

| largestvictory = Colón 5–0 Unión (1918)
Colón 0–5 Unión (1920)

| broadcasters =

| stadiums = Estadio Brigadier López
Estadio 15 de Abril

| map_location =

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}}

The Santa Fe derby (Clásico Santafesino in Spanish) is one of the most fiercely contested derbies in Argentine football. It is played between local clubs Colón and Unión.

Colón play their home games at the Estadio Brigadier General Estanislao López, while Unión play their home games at Estadio 15 de Abril.