Sarah Hake
{{short description|American plant biologist}}
{{Infobox scientist
| honorific_prefix =
| name = Sarah Carter Hake
| honorific_suffix = PhD
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| image = Sarah Hake George Chuck Corn Plant.jpg
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| caption = Sarah Hake and her former postdoc George Chuck examine a corn plant.
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| nationality = American
| fields = Plant Biology
| workplaces = USDA
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| education = Grinnell College
Washington University in St. Louis
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| thesis_title = The genome of Zea mays : its organization and homology to related grasses
| thesis_url = https://catalog.wustl.edu:443/record=b1014093~
| thesis_year = 1980
| doctoral_advisor = Virginia Walbot
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| known_for = Cloning knotted1 a founding member of the homeobox gene family.
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| awards = Stephen Hales prize
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| website = {{URL|pgec.berkeley.edu/sarah-c-hake-lab}}
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Sarah Hake is an American plant developmental biologist who directs the USDA's Plant Gene Expression Center in Albany, CA. In 2009 she was elected a fellow of the American Association for the Advancement of Science and elected member of the National Academy of Sciences.
Early life and education
Hake lived in Iowa until she was 10 years old and then moved to California. She attended Grinnell College, graduating in 1975.{{Cite web|url=https://plantandmicrobiology.berkeley.edu/profile/hake|title=Sarah C. Hake|website=Plant & Microbial Biology | University of California, Berkeley}} As an undergraduate she accompanied a professor to the Botanical Garden in St. Louis which convinced her to study plant biology.{{Cite web|url=https://nature.berkeley.edu/news/2019/09/plant-biologist-farmer-and-grandmother-interview-sarah-hake|title=Plant biologist, farmer, and grandmother: an interview with Sarah Hake|website=UC Berkeley Rausser College of Natural Resources}} After working as a waitress for a year after college, she was accepted into the PhD program at Washington University in St. Louis where she completed her PhD with Virginia Walbot, studying, among other things, the proportion of the DNA in the maize genome which was present as multiple copies. She met Michael Freeling when she was a graduate student and, impressed by research which considered outside the range of traditional genetic research at the time, wrote an NIH proposal to work as a postdoc in his lab at the University of California, Berkeley cloning the gene ADH1. After cloning the ADH1 gene, Hake and Freeling wrote and received a second grant to clone the Knotted1 gene, which they succeeded in doing in 1989.{{cite journal|doi=10.1002/j.1460-2075.1989.tb03343.x|title=Cloning Knotted, the dominant morphological mutant in maize using Ds2 as a transposon tag|year=1989|last1=Hake|first1=Sarah|last2=Vollbrecht|first2=Erik|last3=Freeling|first3=Michael|journal=The EMBO Journal|volume=8|issue=1|pages=15–22|pmid=16453866|pmc=400767}}
After completing her postdoc she was hired as a principal investigator at the USDA Plant Gene Expression Center in Albany, CA. She currently serves as the director for the center and is an adjunct professor in the Department of Plant and Microbial Biology at the University of California, Berkeley.
Research
Hake considers her single most important scientific contribution to be the cloning of Knotted1 the first cloned plant gene with an effect on development.{{cite web|url=https://aspb.org/wp-content/uploads/2020/03/Legacy-Society-Founding-Members-Sarah-Hake.pdf|format=PDF|title=ASPB Legacy Society Founding Members : Sarah Hake|website=Aspb.org|access-date=October 24, 2021}}{{cite journal|doi=10.1038/350241a0|title=The developmental gene Knotted-1 is a member of a maize homeobox gene family|year=1991|last1=Vollbrecht|first1=Erik|last2=Veit|first2=Bruce|last3=Sinha|first3=Neelima|last4=Hake|first4=Sarah|s2cid=4328310|journal=Nature|volume=350|issue=6315|pages=241–243|pmid=1672445|bibcode=1991Natur.350..241V}} Postdocs working in her lab have gone on to clone other genes controlling maize development including terminal
ear1,{{cite journal|doi=10.1038/30239|title=Regulation of leaf initiation by the terminal ear 1 gene of maize|year=1998|last1=Veit|first1=Bruce|last2=Briggs|first2=Steven P.|last3=Schmidt|first3=Robert J.|last4=Yanofsky|first4=Martin F.|last5=Hake|first5=Sarah|s2cid=205000323|journal=Nature|volume=393|issue=6681|pages=166–168|pmid=9603518|bibcode=1998Natur.393..166V}} barren inflorescence2,{{cite journal|pmid=11532912|year=2001|last1=McSteen|first1=P.|author-link1=Paula McSteen|last2=Hake|first2=S.|title=Barren inflorescence2 regulates axillary meristem development in the maize inflorescence|journal=Development|volume=128|issue=15|pages=2881–91|doi=10.1242/dev.128.15.2881}} fasciated ear2,{{cite journal|doi=10.1101/gad.208501|title=The fasciated ear2 gene encodes a leucine-rich repeat receptor-like protein that regulates shoot meristem proliferation in maize|year=2001|last1=Taguchi-Shiobara|first1=F.|last2=Yuan|first2=Z.|last3=Hake|first3=S.|last4=Jackson|first4=D.|journal=Genes & Development|volume=15|issue=20|pages=2755–2766|pmid=11641280|pmc=312812}} tangled,{{cite journal|pmid=8625799|year=1996|last1=Smith|first1=L. G.|last2=Hake|first2=S.|last3=Sylvester|first3=A. W.|title=The tangled-1 mutation alters cell division orientations throughout maize leaf development without altering leaf shape|journal=Development|volume=122|issue=2|pages=481–9|doi=10.1242/dev.122.2.481}} and indeterminate spikelet1.{{cite journal|doi=10.1101/gad.12.8.1145|title=The control of maize spikelet meristem fate by the APETALA2-like gene indeterminate spikelet1|year=1998|last1=Chuck|first1=G.|last2=Meeley|first2=R. B.|last3=Hake|first3=S.|journal=Genes & Development|volume=12|issue=8|pages=1145–1154|pmid=9553044|pmc=316712}}
Recognition
- In 2007 Hake received Stephen Hales prize from American Society of Plant Biologists.{{Cite web|url=https://aspb.org/awards-funding/aspb-awards/stephen-hales-prize/|title=Stephen Hales Prize|website=American Society of Plant Biologists}}
- In 2009 Hake was elected a fellow of the American Association for the Advancement of Science.{{Cite web|url=https://www.aaas.org/fellows/historic|title=Historic Fellows | American Association for the Advancement of Science|website=Aaas.org}}
- In 2009 Hake was elected to the National Academy of Sciences.{{Cite web|url=http://www.nasonline.org/member-directory/members/20017189.html|title=Sarah Hake|website=Nasonline.org}}
Personal life
Hake has two children born while she was a postdoc. Since she was a postdoc at UC-Berkeley, Hake and her family live on the Gospel Flat Farm near Bolinas, California.
References
{{reflist}}
External links
- {{google scholar id|LXf4wPoAAAAJ}}
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Category:Grinnell College alumni
Category:Washington University in St. Louis alumni
Category:University of California, Berkeley College of Natural Resources faculty
Category:Fellows of the American Association for the Advancement of Science
Category:Members of the United States National Academy of Sciences