Scott A. Small
{{Short description|American neurologist and neuroscientist}}
{{Infobox scientist
| name = Scott A. Small
| image = Scott A. Small.png
| fields = Neurobiology of Disease
| workplaces = Columbia University
| alma_mater = New York University (BA)
Columbia University (MD)
| doctoral_advisor = Eric Kandel
}}
Scott A. Small is an American neurologist and neuroscientist known for his work in Alzheimer's disease and normal cognitive aging.{{Cite web|title=Scott A. Small|url=https://scholar.google.com/citations?user=W1kXLwYAAAAJ&hl=en|access-date=2021-03-05|website=scholar.google.com}} His research focuses on the hippocampus, a circuit in the brain targeted by Alzheimer's disease, aging, and schizophrenia. Small is the Director of the Alzheimer's Disease Research Center at Columbia University, where he is the Boris and Rose Katz Professor of Neurology. He is also appointed in Radiology and in Psychiatry, where he directs the Schizophrenia Research program.
In an interview with Mike Pesca, he mentioned that he served in the Israel Defense Forces during the 1982 Lebanon War.{{cite web|title=Thot Thoughts interview with Scott Small|url=https://www.mikepesca.com/thegist/episode/3bfcce3f/thot-thoughts|author=Mike Pesca|date=July 22, 2022}}
Work
Small has developed high-resolution functional MRI applications that can pinpoint the areas of the hippocampus most affected by aging and disease.{{Cite journal|last1=Small|first1=Scott A.|last2=Schobel|first2=Scott A.|last3=Buxton|first3=Richard B.|last4=Witter|first4=Menno P.|last5=Barnes|first5=Carol A.|date=October 2011|title=A pathophysiological framework of hippocampal dysfunction in ageing and disease|url= |journal=Nature Reviews Neuroscience|language=en|volume=12|issue=10|pages=585–601|doi=10.1038/nrn3085|pmid=21897434|issn=1471-0048|pmc=3312472}} His lab uses this ‘anatomical biology’ approach of isolating pathogenic mechanisms to identify potential causes of these disorders and inform on drug discovery and development.{{Cite journal|last=Small|first=Scott A.|date=2014-10-01|title=Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability|url=https://pubmed.ncbi.nlm.nih.gov/25277453/|journal=Neuron|volume=84|issue=1|pages=32–39|doi=10.1016/j.neuron.2014.08.030|issn=1097-4199|pmc=4185396|pmid=25277453}}{{Cite journal|last1=Small|first1=Scott A.|last2=Petsko|first2=Gregory A.|date=March 2015|title=Retromer in Alzheimer disease, Parkinson disease and other neurological disorders|url=https://pubmed.ncbi.nlm.nih.gov/25669742/|journal=Nature Reviews. Neuroscience|volume=16|issue=3|pages=126–132|doi=10.1038/nrn3896|issn=1471-0048|pmid=25669742|s2cid=5166260}}{{Cite journal|last1=Brickman|first1=Adam M.|last2=Khan|first2=Usman A.|last3=Provenzano|first3=Frank A.|last4=Yeung|first4=Lok-Kin|last5=Suzuki|first5=Wendy|last6=Schroeter|first6=Hagen|last7=Wall|first7=Melanie|author7-link=Melanie Wall|last8=Sloan|first8=Richard P.|last9=Small|first9=Scott A.|date=December 2014|title=Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults|url= |journal=Nature Neuroscience|language=en|volume=17|issue=12|pages=1798–1803|doi=10.1038/nn.3850|pmid=25344629|issn=1546-1726|pmc=4940121}}{{Cite journal|last1=Schobel|first1=Scott A.|last2=Chaudhury|first2=Nashid H.|last3=Khan|first3=Usman A.|last4=Paniagua|first4=Beatriz|last5=Styner|first5=Martin A.|last6=Asllani|first6=Iris|last7=Inbar|first7=Benjamin P.|last8=Corcoran|first8=Cheryl M.|last9=Lieberman|first9=Jeffrey A.|last10=Moore|first10=Holly|last11=Small|first11=Scott A.|date=2013-04-10|title=Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver|url=https://pubmed.ncbi.nlm.nih.gov/23583108/|journal=Neuron|volume=78|issue=1|pages=81–93|doi=10.1016/j.neuron.2013.02.011|issn=1097-4199|pmc=3966570|pmid=23583108}} To date, these mechanistic insights have led to the testing of therapeutic interventions for three hippocampal-based conditions: retromer-enhancers for Alzheimer's disease;{{Cite journal|last1=Mecozzi|first1=Vincent J.|last2=Berman|first2=Diego E.|last3=Simoes|first3=Sabrina|last4=Vetanovetz|first4=Chris|last5=Awal|first5=Mehraj R.|last6=Patel|first6=Vivek M.|last7=Schneider|first7=Remy T.|last8=Petsko|first8=Gregory A.|last9=Ringe|first9=Dagmar|last10=Small|first10=Scott A.|date=June 2014|title=Pharmacological chaperones stabilize retromer to limit APP processing|url= |journal=Nature Chemical Biology|language=en|volume=10|issue=6|pages=443–449|doi=10.1038/nchembio.1508|pmid=24747528|issn=1552-4469|pmc=4076047}}{{Cite journal|last1=Small|first1=Scott A.|last2=Petsko|first2=Gregory A.|date=2020-12-02|title=Endosomal recycling reconciles the Alzheimer's disease paradox|url= |journal=Science Translational Medicine|language=en|volume=12|issue=572|pages=eabb1717|doi=10.1126/scitranslmed.abb1717|issn=1946-6234|pmid=33268506|s2cid=227249225|pmc=8025181}} dietary flavanols for cognitive aging;{{Cite journal|last1=Sloan|first1=Richard P.|last2=Wall|first2=Melanie|author2-link=Melanie Wall|last3=Yeung|first3=Lok-Kin|last4=Feng|first4=Tianshu|last5=Feng|first5=Xinyang|last6=Provenzano|first6=Frank|last7=Schroeter|first7=Hagen|last8=Lauriola|first8=Vincenzo|last9=Brickman|first9=Adam M.|last10=Small|first10=Scott A.|date=2021-02-15|title=Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial|journal=Scientific Reports|language=en|volume=11|issue=1|pages=3837|doi=10.1038/s41598-021-83370-2|pmid=33589674|pmc=7884710|issn=2045-2322|doi-access=free}} and glutamate-reducers for schizophrenia.
Small has authored more than 140 papers and is an inventor of 10 patents. He is the author of the 2021 book, Forgetting: The Benefits of Not Remembering, published by Crown/Penguin Random House ({{ISBN|978-0-593-13619-5}}).
References
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Category:American neurologists
Category:American neuroscientists
Category:Year of birth missing (living people)
Category:Columbia University faculty
Category:New York University alumni
Category:Columbia University Vagelos College of Physicians and Surgeons alumni