Sean Murphy

• Seán Óg Murphy (1897–1956), Irish hurler
• Seán Murphy (hurler) (born 1947), Irish hurler
• Seán Murphy (Gaelic footballer) (1932–2025), Irish Gaelic football player
• Sean Murphy (footballer, born 1995), Scottish footballer
• Sean Murphy (boxer) (born 1964), English Commonwealth Games gold-winning boxer
• Sean Murphy (swimmer) (born 1964), Canadian swimmer
• Sean Murphy (golfer) (born 1965), American golfer
• Sean Murphy (racing driver) (born 1984), in Auckland, New Zealand
• Sean Murphy (baseball) (born 1994), American baseball player
• Sean Murphy (rower) (born 1996), Australian rower

• Sean Murphy (artist), American comic book creator
• Sean Murphy (cryptographer), professor at Royal Holloway, University of London
• Sean Murphy (journalist) (born 1958), Australian journalist
• Sean Murphy (photographer), American photographer
• Sean D. Murphy, professor at George Washington University
• Sean Murphy (Oz), a fictional character on the television series Oz

• Sean Murphy-Bunting, American football player
• Shaun Murphy (disambiguation)
• Shawn Murphy (disambiguation)

{{human name disambiguation|Murphy, Sean}}