Sebaceous hyperplasia

{{Infobox medical condition (new)

| name = Sebaceous hyperplasia

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| image = Sebaceous hyperplasia.jpg

| caption = Sebaceous hyperplasia in 55-year-old woman. Diagnosis was histologically verified.

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| field = Dermatology

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Sebaceous hyperplasia is a disorder of the sebaceous glands in which they become enlarged, producing flesh-colored or yellowish, shiny, often umbilicated bumps.{{cite book |author1=James, William D. |author2=Berger, Timothy G. |title=Andrews' Diseases of the Skin: Clinical Dermatology |publisher=Saunders Elsevier |year=2006 |pages=662 |isbn=978-0-7216-2921-6 |display-authors=etal}} Sebaceous hyperplasia, primarily affecting older patients in high-concentration areas like the face, head, and neck, typically has a 2-4 mm diameter and causes no symptoms. The lesions are often surrounded by telangiectatic blood vessels, also known as "crown vessels," and a central dell, which is in line with the origin of the lesions.

Sebaceous glands are glands located within the skin and are responsible for secreting an oily substance named sebum. They are commonly associated with hair follicles but they can be found in hairless regions of the skin as well. Their secretion lubricates the skin, protecting it from drying out or becoming irritated.{{Cite book|title = Dellmann's textbook of veterinary histology|author1=Jo Ann Coers Eurell |author2=Brian L. Frappier |publisher = Wiley |year = 2006 |isbn = 9780781741484 |pages = 29|url=https://books.google.com/books?id=FnS4uiOlRT0C&pg=PA29}}

Murine studies suggest topical irritants and carcinogens may contribute to sebaceous hyperplasia development, with immunosuppression with cyclosporin A or HIV infection increasing the likelihood.

Sebaceous hyperplasia is a condition that can be diagnosed clinically but requires a biopsy for confirmation. It shares similarities with folliculosebaceous unit architecture but has larger and expanded sebaceous glands. Identifying sebaceous hyperplasia using dermatoscopy can help identify it from other lesions. The dermoscopic characteristics include "crown vessels" clusters of white or yellow nodules, a distinct asymmetrical milky-white structure called the cumulus sign, and a central umbilication called the "bonbon toffee sign."

Sebaceous hyperplasia treatment involves various techniques like cryotherapy, bichloroacetic acid, shave excision, carbon dioxide laser ablation, electrodessication, erbium/yttrium aluminum garnet laser ablation, and pulsed-dye laser photothermolysis.

Signs and symptoms

Sebaceous hyperplasia primarily affects older patients in areas with high concentrations of sebaceous glands, such as the face, head, and neck.{{cite journal | last1=Kumar | first1=P. | last2=Marks | first2=R. | title=Sebaceous gland hyperplasia and senile comedones: a prevalence study in elderly hospitalized patients | journal=British Journal of Dermatology | volume=117 | issue=2 | date=1987 | issn=0007-0963 | doi=10.1111/j.1365-2133.1987.tb04121.x | pages=231–236| pmid=2958079 }} It typically manifests as yellowish-colored skin with small papules that are often surrounded by telangiectatic blood vessels, also known as "crown vessels," and a central dell that is in line with the origin of the lesions, which is a dilated central follicular infundibulum.{{cite journal | last1=Luderschmidt | first1=Christoph. | last2=Plewig | first2=Gerd. | title=Circumscribed Sebaceous Gland Hyperplasia: Autoradiographic and Histoplanimetric Studies | journal=Journal of Investigative Dermatology | publisher=Elsevier BV | volume=70 | issue=4 | year=1978 | issn=0022-202X | doi=10.1111/1523-1747.ep12541329 | pages=207–209| pmid=641372 }}{{cite journal | last1=Tetzlaff | first1=Michael T. | last2=North | first2=Jeffrey | last3=Esmaeli | first3=Bita | title=Update on sebaceous neoplasia: the morphologic spectrum and molecular genetic drivers of carcinoma | journal=Diagnostic Histopathology | publisher=Elsevier BV | volume=25 | issue=3 | year=2019 | issn=1756-2317 | doi=10.1016/j.mpdhp.2019.01.001 | pages=102–109}} Most lesions have a diameter of 2-4 mm and cause no symptoms.{{cite journal | last1=Hogan | first1=Daniel | last2=Mohammad | first2=Samya | title=Sebaceous hyperplasia | journal=Expert Review of Dermatology | volume=6 | issue=1 | date=2011 | issn=1746-9872 | doi=10.1586/edm.11.2 | pages=91–96}}

Causes

Although the etiology is unknown, murine studies have revealed that topical irritants and carcinogens may be involved in the development of sebaceous hyperplasia.{{cite journal | last1=Ito | first1=Masaaki | last2=Motoyoshi | first2=Katsuhiro | last3=Suzuki | first3=Megumi | last4=Sato | first4=Yoshio | title=Sebaceous Gland Hyperplasia on Rabbit Pinna Induced by Tetradecane | journal=Journal of Investigative Dermatology | publisher=Elsevier BV | volume=85 | issue=3 | year=1985 | issn=0022-202X | doi=10.1111/1523-1747.ep12276720 | pages=249–254| pmid=2411823 }}{{cite journal | last1=Rice | first1=Jerry M. | last2=Anderson | first2=Lucy M. | title=Sebaceous adenomas with associated epidermal hyperplasia and papilloma formation as a major type of tumor induced in mouse skin by high doses of carcinogens | journal=Cancer Letters | publisher=Elsevier BV | volume=33 | issue=3 | year=1986 | issn=0304-3835 | doi=10.1016/0304-3835(86)90069-8 | pages=295–306| pmid=3100020 }}

Immunosuppression with cyclosporin A{{cite journal | last1=Boschnakow | first1=A. | last2=May | first2=T. | last3=Assaf | first3=C. | last4=Tebbe | first4=B. | last5=Zouboulis | first5=CH.C. | title=Ciclosporin A-induced sebaceous gland hyperplasia | journal=British Journal of Dermatology | publisher=Oxford University Press (OUP) | volume=149 | issue=1 | year=2003 | issn=0007-0963 | doi=10.1046/j.1365-2133.2003.05397.x | pages=198–200}} or HIV infection increases the likelihood of developing sebaceous hyperplasia significantly.{{cite journal | last1=Short | first1=K. A. | last2=Williams | first2=A. | last3=Creamer | first3=D. | last4=Fuller | first4=L. C. | title=Sebaceous gland hyperplasia, human immunodeficiency virus and highly active anti-retroviral therapy | journal=Clinical and Experimental Dermatology | volume=33 | issue=3 | date=2008 | issn=0307-6938 | doi=10.1111/j.1365-2230.2007.02670.x | pages=354–355| pmid=18346183 }}

Diagnosis

Although sebaceous hyperplasia can be diagnosed clinically, a biopsy is necessary for confirmation in cases of doubt.{{cite journal | last1=Lim | first1=Geoffrey F.S. | last2=Cusack | first2=Carrie Ann R. | last3=Kist | first3=Joseph M. | title=Perioral Lesions and Dermatoses | journal=Dental Clinics of North America | publisher=Elsevier BV | volume=58 | issue=2 | year=2014 | issn=0011-8532 | doi=10.1016/j.cden.2013.12.009 | pages=401–435| pmid=24655530 }} The differential diagnosis for sebaceous hyperplasia includes nevus sebaceous, sebaceous carcinoma, sebaceous adenoma, basal cell carcinoma, molluscum contagiosum, and small epidermal inclusion cysts.

Sebaceous hyperplasia shares histopathological similarities with the typical architecture of the folliculosebaceous unit, but with larger and expanded sebaceous glands.{{cite journal | last1=Kumar | first1=P. | last2=Barton | first2=S.P. | last3=Marks | first3=R. | title=Tissue measurements in senile sebaceous gland hyperplasia | journal=British Journal of Dermatology | volume=118 | issue=3 | date=1988 | issn=0007-0963 | doi=10.1111/j.1365-2133.1988.tb02434.x | pages=397–402| pmid=3355781 }}{{cite journal | last1=Eisen | first1=Daniel B. | last2=Michael | first2=Daniel J. | title=Sebaceous lesions and their associated syndromes: Part I | journal=Journal of the American Academy of Dermatology | volume=61 | issue=4 | date=2009 | doi=10.1016/j.jaad.2009.04.058 | pages=549–560| pmid=19751879 }}

To help identify sebaceous hyperplasia from other lesions, dermatoscopy may be utilized. A cluster of white or yellow nodules encircled by tiny, nonarborizing branching vessels known as "crown vessels" are among the dermoscopic characteristics of sebaceous hyperplasia.{{cite journal | last1=Kim | first1=Nancy H. | last2=Zell | first2=Deborah S. | last3=Kolm | first3=Isabel | last4=Oliviero | first4=Margaret | last5=Rabinovitz | first5=Harold S. | title=The Dermoscopic Differential Diagnosis of Yellow Lobularlike Structures | journal=Archives of Dermatology | publisher=American Medical Association (AMA) | volume=144 | issue=7 | date=2008-07-01 | issn=0003-987X | doi=10.1001/archderm.144.7.962 | page=| pmid=18645159 }}{{cite journal | last1=Zaballos | first1=Pedro | last2=Ara | first2=Mariano | last3=Puig | first3=Susana | last4=Malvehy | first4=Josep | title=Dermoscopy of Sebaceous Hyperplasia | journal=Archives of Dermatology | publisher=American Medical Association (AMA) | volume=141 | issue=6 | date=2005-06-01 | issn=0003-987X | doi=10.1001/archderm.141.6.808 | page=}} On dermatoscopy, a distinct asymmetrical milky-white structure known as the cumulus sign has been identified in cases with sebaceous hyperplasia. Unlike the traditional crown vessels, some writers describe the blood vessels as "multiple tree-like branches."{{cite journal | last1=Bryden | first1=A. M. | last2=Dawe | first2=R. S. | last3=Fleming | first3=C. | title=Dermatoscopic features of benign sebaceous proliferation | journal=Clinical and Experimental Dermatology | publisher=Oxford University Press (OUP) | volume=29 | issue=6 | year=2004 | issn=0307-6938 | doi=10.1111/j.1365-2230.2004.1612.x | pages=676–677| pmid=15550152 }} A central umbilication encircled by the cumulus sign was another distinguishing characteristic of dermatoscopy; the authors dubbed this the "bonbon toffee sign."{{cite journal | last1=Oztas | first1=P | last2=Polat | first2=M | last3=Oztas | first3=M | last4=Alli | first4=N | last5=Ustun | first5=H | title=Bonbon toffee sign: a new dermatoscopic feature for sebaceous hyperplasia | journal=Journal of the European Academy of Dermatology and Venereology | publisher=Wiley | volume=22 | issue=10 | date=2008-09-10 | issn=0926-9959 | doi=10.1111/j.1468-3083.2008.02827.x | pages=1200–1202| pmid=18540985 }}

Treatment

Treatment for sebaceous hyperplasia is carried out for cosmetic reasons. There are numerous techniques that have been reported, including cryotherapy, bichloroacetic acid, shave excision, carbon dioxide laser ablation, electrodessication, erbium or yttrium aluminum garnet laser ablation, and pulsed-dye laser photothermolysis.{{cite journal | last1=No | first1=David | last2=McClaren | first2=Marla | last3=Chotzen | first3=Vera | last4=Kilmer | first4=Suzanne L. | title=Sebaceous Hyperplasia Treated With a 1450-nm Diode Laser | journal=Dermatologic Surgery | volume=30 | issue=3 | date=2004 | issn=1076-0512 | doi=10.1111/j.1524-4725.2004.30105.x | pages=382–384| pmid=15008865 }}

Additional photos

File:Photography of sebaceous hyperplasia.jpg|Photography of sebaceous hyperplasia, showing a group of papules, in this case on the chest with linear distribution pattern.

File:Dermoscopy of sebaceous hyperplasia.jpg|Dermoscopy of sebaceous hyperplasia. Note the aggregation of yellowish-white clods with linear vessels between or above the clods.

File:High dynamic range dermoscopy of sebaceous hyperplasia.jpg|Dermoscopy of sebaceous hyperplasia with digital high dynamic range. Note the multi-lobulated clods with central openings.

File:Histopathology of sebaceous hyperplasia.jpg|H&E staining of biopsied lesion of sebaceous hyperplasia: Note the multiple, mature sebaceous lobules attached to the central dilated duct in the upper dermis.

File:Malignant Melanoma right temple medial adjacent sebaceous hyperplasia right temple lateral.jpg|Sebaceous hyperplasia, lateral right temple marked for biopsy with adjacent malignant melanoma in situ, evolving, medial right temple

File:Sebaceaous Hyperplasia Chronic folliculits Right Mid Chest.jpg|Sebaceous hyperplasia with surrounding chronic folliculitis, right mid chest

References

External links

[https://dermnetnz.org/topics/sebaceous-hyperplasia DermNet]
[https://my.clevelandclinic.org/health/diseases/22670-sebaceous-hyperplasia Cleveland Clinic]

{{Medical resources

| ICD11 = {{ICD11|ED91.1}}

| ICD10 = {{ICD10|L73.8}}

| ICD10CM =

| ICD9 = {{ICD9|706.9}}

| ICDO =

| OMIM = 601700

| MeshID = C537530

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| SNOMED CT = 238748009

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| eMedicineSubj = article

| eMedicineTopic = 1059368

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Category:Epidermal nevi, neoplasms, and cysts