Secobarbital/brallobarbital/hydroxyzine

{{Short description|Combination drug}}

{{cs1 config|name-list-style=vanc}}

{{Use dmy dates|date=September 2020}}

{{Infobox drug

| drug_name =

| type = combo

| component1 = Brallobarbital

| class1 = Barbiturate

| component2 = Secobarbital

| class2 = Barbiturate

| component3 = Hydroxyzine

| class3 = Antihistamine

| image = Vesparax.jpg

| alt =

| caption =

| tradename = Vesparax

| Drugs.com =

| MedlinePlus =

| licence_EU =

| licence_US =

| pregnancy_AU =

| pregnancy_US =

| pregnancy_category =

| legal_AU =

| legal_AU_comment =

| legal_CA =

| legal_UK =

| legal_US =

| legal_UN =

| legal_NZ =

| legal_status =

| routes_of_administration =

| CAS_number = 61112-40-1

| ATCvet =

| ATC_prefix =

| ATC_suffix =

| PubChem =

| DrugBank =

}}

Secobarbital/brallobarbital/hydroxyzine was a combination tablet containing 50 mg brallobarbital, 150 mg secobarbital and 50 mg hydroxyzine{{cite journal | vauthors = Lhermann J | title = [Clinical Application of a New Very Active Hypnotic Associating Sodium Secobarbital, Calcium Brallobarbital and Hydroxyzine (Uc-8130)] | journal = Gazette Médicale de France | volume = 71 | pages = 961–2 | date = March 1964 | pmid = 14142825 }} that was used as a sedative. It was sold under the brand name Vesparax. This drug has been withdrawn from the market in most countries.

Hydroxyzine and secobarbital lengthen the half-life of brallobarbital. Because of this long half-life, it has symptoms resembling a hangover on the next day.{{cite journal | vauthors = Yih TD, Rossum JM | title = Peculiar pharmacokinetics of brallobarbital as a source of complications in Vesparax intoxication | journal = Xenobiotica; the Fate of Foreign Compounds in Biological Systems | volume = 6 | issue = 6 | pages = 355–62 | date = June 1976 | pmid = 969563 | doi = 10.3109/00498257609151647 }}{{cite journal | vauthors = Fischbach R | title = Efficacy and safety of midazolam and vesparax in treatment of sleep disorders | journal = British Journal of Clinical Pharmacology | volume = 16 | pages = 167S–171S | year = 1983 | issue = Suppl 1 | pmid = 6138072 | pmc = 1428085 | doi = 10.1111/j.1365-2125.1983.tb02290.x }}

Jimi Hendrix was under the influence of Vesparax when he died of asphyxia due to aspiration of vomit on 18 September 1970.{{Cite book | last = Brown | first = Tony | date = 1997 | title = Jimi Hendrix: The Final Days | publisher = Omnibus Press | isbn = 978-0-7119-5238-6|page=159}}