Secretin family

{{Pfam_box

| Symbol = Hormone_2

| Name =

| image =1gcn_opm.png

| width =

| caption = Glucagon ({{PDB3|1gcn}})

| Pfam= PF00123

| InterPro= IPR000532

| SMART=

| Prosite = PDOC00233

| SCOP = 1gcn

| TCDB =

| OPM family= 145

| OPM protein= 1gcn

| PDB=

}}

Glucagon/gastric inhibitory polypeptide/secretin/vasoactive intestinal peptide hormones are a family of evolutionarily related peptide hormones that regulate activity of G-protein-coupled receptors from the secretin receptor family. A number of polypeptidic hormones, mainly expressed in the intestine or the pancreas, belong to a group of these structurally related peptides.{{cite journal | vauthors = Mutt V | title = Vasoactive intestinal polypeptide and related peptides. Isolation and chemistry | journal = Annals of the New York Academy of Sciences | volume = 527 | pages = 1–19 | year = 1988 | issue = 1 | pmid = 3133967 | doi = 10.1111/j.1749-6632.1988.tb26968.x | bibcode = 1988NYASA.527....1M | s2cid = 40431562 }}{{cite journal | vauthors = Bataille D, Blache P, Mercier F, Jarrousse C, Kervran A, Dufour M, Mangeat P, Dubrasquet M, Mallat A, Lotersztajn S | title = Glucagon and related peptides. Molecular structure and biological specificity | journal = Annals of the New York Academy of Sciences | volume = 527 | pages = 168–85 | year = 1988 | issue = 1 | pmid = 3291691 | doi = 10.1111/j.1749-6632.1988.tb26980.x | bibcode = 1988NYASA.527..168B | s2cid = 7798790 }}

This family of hormones are produced from (preproglucagon), which is cleaved to produce glucagon, glucagon-like protein I, glucagon-like protein II, and glicentin.{{cite journal | vauthors = Pollock HG, Hamilton JW, Rouse JB, Ebner KE, Rawitch AB | title = Isolation of peptide hormones from the pancreas of the bullfrog (Rana catesbeiana). Amino acid sequences of pancreatic polypeptide, oxyntomodulin, and two glucagon-like peptides | journal = The Journal of Biological Chemistry | volume = 263 | issue = 20 | pages = 9746–51 | date = July 1988 | doi = 10.1016/S0021-9258(19)81581-8 | pmid = 3260236 | doi-access = free }} Other members of the structurally similar group include secretin, gastric inhibitory peptide, vasoactive intestinal peptide, prealbumin, peptide HI-27, and growth hormone releasing factor.

One hormone, glucagon, is fully conserved in all mammalian species in which it has been studied.{{cite journal | vauthors = Conlon JM, Thim L | title = Primary structure of glucagon from an elasmobranchian fish. Torpedo marmorata | journal = General and Comparative Endocrinology | volume = 60 | issue = 3 | pages = 398–405 | date = December 1985 | pmid = 4076759 | doi = 10.1016/0016-6480(85)90073-5 }}