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Secretin receptor

{{Short description|Protein-coding gene in the species Homo sapiens}}

{{Infobox_gene}}

The secretin receptor is a protein that in humans is encoded by the SCTR gene. This protein is a G protein-coupled receptor which binds secretin and is the leading member (i.e., first cloned) of the secretin receptor family, also called class B GPCR subfamily.{{cite journal | vauthors = Dong M, Miller LJ | title = Molecular pharmacology of the secretin receptor | journal = Receptors & Channels | volume = 8 | issue = 3–4 | pages = 189–200 | year = 2002 | pmid = 12529936 | doi = 10.1080/10606820213686 | doi-access = free }}

Interactions

The secretin receptor has been shown to interact with pituitary adenylate cyclase activating peptide.{{cite journal | vauthors = Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT | title = Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release | journal = The American Journal of Physiology | volume = 263 | issue = 6 Pt 1 | pages = G901-7 | date = December 1992 | doi = 10.1152/ajpgi.1992.263.6.G901 | pmid = 1335692 }}

References

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Further reading

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  • {{cite journal | vauthors = Ulrich CD, Holtmann M, Miller LJ | title = Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors | journal = Gastroenterology | volume = 114 | issue = 2 | pages = 382–97 | date = February 1998 | pmid = 9453500 | doi = 10.1016/S0016-5085(98)70491-3 }}
  • {{cite journal | vauthors = Felley CP, Qian JM, Mantey S, Pradhan T, Jensen RT | title = Chief cells possess a receptor with high affinity for PACAP and VIP that stimulates pepsinogen release | journal = The American Journal of Physiology | volume = 263 | issue = 6 Pt 1 | pages = G901-7 | date = December 1992 | doi = 10.1152/ajpgi.1992.263.6.G901 | pmid = 1335692 }}
  • {{cite journal | vauthors = Ishihara T, Nakamura S, Kaziro Y, Takahashi T, Takahashi K, Nagata S | title = Molecular cloning and expression of a cDNA encoding the secretin receptor | journal = The EMBO Journal | volume = 10 | issue = 7 | pages = 1635–41 | date = July 1991 | pmid = 1646711 | pmc = 452832 | doi = 10.1002/j.1460-2075.1991.tb07686.x}}
  • {{cite journal | vauthors = Robberecht P, De Neef P, Waelbroeck M, Camus JC, Scemama JL, Fourmy D, Pradayrol L, Vaysse N, Christophe J | title = Secretin receptors in human pancreatic membranes | journal = Pancreas | volume = 3 | issue = 5 | pages = 529–35 | year = 1988 | pmid = 3186683 | doi = 10.1097/00006676-198810000-00004 | s2cid = 23220534 }}
  • {{cite journal | vauthors = Chow BK | title = Molecular cloning and functional characterization of a human secretin receptor | journal = Biochemical and Biophysical Research Communications | volume = 212 | issue = 1 | pages = 204–11 | date = July 1995 | pmid = 7612008 | doi = 10.1006/bbrc.1995.1957 }}
  • {{cite journal | vauthors = Patel DR, Kong Y, Sreedharan SP | title = Molecular cloning and expression of a human secretin receptor | journal = Molecular Pharmacology | volume = 47 | issue = 3 | pages = 467–73 | date = March 1995 | pmid = 7700244 }}
  • {{cite journal | vauthors = Holtmann MH, Hadac EM, Miller LJ | title = Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors | journal = The Journal of Biological Chemistry | volume = 270 | issue = 24 | pages = 14394–8 | date = June 1995 | pmid = 7782300 | doi = 10.1074/jbc.270.24.14394 | doi-access = free }}
  • {{cite journal | vauthors = Jiang S, Ulrich C | title = Molecular cloning and functional expression of a human pancreatic secretin receptor | journal = Biochemical and Biophysical Research Communications | volume = 207 | issue = 3 | pages = 883–90 | date = February 1995 | pmid = 7864894 | doi = 10.1006/bbrc.1995.1268 }}
  • {{cite journal | vauthors = Sreedharan SP, Patel DR, Huang JX, Goetzl EJ | title = Cloning and functional expression of a human neuroendocrine vasoactive intestinal peptide receptor | journal = Biochemical and Biophysical Research Communications | volume = 193 | issue = 2 | pages = 546–53 | date = June 1993 | pmid = 8390245 | doi = 10.1006/bbrc.1993.1658 }}
  • {{cite journal | vauthors = Mark HF, Chow BK | title = Localization of the gene encoding the secretin receptor, SCTR, on human chromosome 2q14.1 by fluorescence in situ hybridization and chromosome morphometry | journal = Genomics | volume = 29 | issue = 3 | pages = 817–8 | date = October 1995 | pmid = 8575789 | doi = 10.1006/geno.1995.9922 }}
  • {{cite journal | vauthors = Vilardaga JP, di Paolo E, de Neef P, Waelbroeck M, Bollen A, Robberecht P | title = Lysine 173 residue within the first exoloop of rat secretin receptor is involved in carboxylate moiety recognition of Asp 3 in secretin | journal = Biochemical and Biophysical Research Communications | volume = 218 | issue = 3 | pages = 842–6 | date = January 1996 | pmid = 8579602 | doi = 10.1006/bbrc.1996.0150 }}
  • {{cite journal | vauthors = Chow BK | title = Functional antagonism of the human secretin receptor by a recombinant protein encoding the N-terminal ectodomain of the receptor | journal = Receptors & Signal Transduction | volume = 7 | issue = 3 | pages = 143–50 | year = 1998 | pmid = 9440501 }}
  • {{cite journal | vauthors = Shetzline MA, Premont RT, Walker JK, Vigna SR, Caron MG | title = A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6756–62 | date = March 1998 | pmid = 9506976 | doi = 10.1074/jbc.273.12.6756 | doi-access = free }}
  • {{cite journal | vauthors = Ho PK, Fong RS, Kai HS, Lau EH, Ngan ES, Cotton CU, Chow BK | title = The human secretin receptor gene: genomic organization and promoter characterization | journal = FEBS Letters | volume = 455 | issue = 3 | pages = 209–14 | date = July 1999 | pmid = 10437774 | doi = 10.1016/S0014-5793(99)00864-9 | s2cid = 1197008 }}
  • {{cite journal | vauthors = Pang RT, Ng SS, Cheng CH, Holtmann MH, Miller LJ, Chow BK | title = Role of N-linked glycosylation on the function and expression of the human secretin receptor | journal = Endocrinology | volume = 140 | issue = 11 | pages = 5102–11 | date = November 1999 | pmid = 10537138 | doi = 10.1210/endo.140.11.7134 | doi-access = free }}
  • {{cite journal | vauthors = Chan KY, Pang RT, Chow BK | title = Functional segregation of the highly conserved basic motifs within the third endoloop of the human secretin receptor | journal = Endocrinology | volume = 142 | issue = 9 | pages = 3926–34 | date = September 2001 | pmid = 11517171 | doi = 10.1210/endo.142.9.8389 | doi-access = free }}
  • {{cite journal | vauthors = Pang RT, Lee LT, Ng SS, Yung WH, Chow BK | title = CpG methylation and transcription factors Sp1 and Sp3 regulate the expression of the human secretin receptor gene | journal = Molecular Endocrinology | volume = 18 | issue = 2 | pages = 471–83 | date = February 2004 | pmid = 14645499 | doi = 10.1210/me.2003-0245 | doi-access = free }}

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External links

  • [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2297 IUPHAR GPCR Database - Secretin receptor] {{Webarchive|url=https://web.archive.org/web/20160303212959/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2297 |date=2016-03-03 }}
  • {{MeshName|secretin+receptor}}

{{G protein-coupled receptors}}

Category:G protein-coupled receptors

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