Selenophosphate synthetase 1
{{Short description|Protein-coding gene in the species Homo sapiens}}
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Selenide, water dikinase 1 is an enzyme that in humans is encoded by the SEPHS1 gene.{{cite journal |author1=Low SC |author2=Harney JW |author3=Berry MJ | title = Cloning and functional characterization of human selenophosphate synthetase, an essential component of selenoprotein synthesis | journal = J Biol Chem | volume = 270 | issue = 37 | pages = 21659–64 |date=Oct 1995 | pmid = 7665581 | doi =10.1074/jbc.270.37.21659 | doi-access =free }}{{cite web | title = Entrez Gene: SEPHS1 selenophosphate synthetase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22929}}
This protein functions as an enzyme that synthesizes selenophosphate from selenide and ATP. Selenophosphate is the selenium donor used to synthesize selenocysteine, which is co-translationally incorporated into selenoproteins at in-frame UGA codons.
References
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Further reading
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- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Tamura T, Yamamoto S, Takahata M, etal |title=Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 46 |pages= 16162–7 |year= 2004 |pmid= 15534230 |doi= 10.1073/pnas.0406313101 | pmc=528966 |bibcode=2004PNAS..10116162T |doi-access=free }}
- {{cite journal |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 |hdl= 11858/00-001M-0000-0010-8592-0 |s2cid=8235923 |hdl-access= free }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R |s2cid=4427026 }}
- {{cite journal |vauthors=Saiki R, Nagata A, Kainou T, etal |title=Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans. |journal=FEBS J. |volume=272 |issue= 21 |pages= 5606–22 |year= 2005 |pmid= 16262699 |doi= 10.1111/j.1742-4658.2005.04956.x |s2cid=13735213 |doi-access=free }}
- {{cite journal |vauthors=Chung HJ, Yoon SI, Shin SH, etal |title=p53-Mediated enhancement of radiosensitivity by selenophosphate synthetase 1 overexpression. |journal=J. Cell. Physiol. |volume=209 |issue= 1 |pages= 131–41 |year= 2006 |pmid= 16786570 |doi= 10.1002/jcp.20714 |s2cid=24313890 }}
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