Senotherapy

{{short description|Basic research field}}

Senotherapeutics refers to therapeutic agents/strategies that specifically target cellular senescence.Childs et al. (2015). [http://www.nature.com/nm/journal/v21/n12/full/nm.4000.html Cellular senescence in aging and age-related disease: from mechanisms to therapy] Nature Medicine {{doi:10.1038/nm.4000}} Senotherapeutics include emerging senolytic/senoptotic small molecules that specifically induce cell death in senescent cells Chang J., Wang Y.,Shao L. et al., & Zhou D. (2015). [http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.4010.html Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice]. Nature Medicine {{doi|10.1038/nm.4010}} and agents that inhibit the pro-inflammatory senescent secretome.Xu et al. (2015). [http://www.pnas.org/content/112/46/E6301.abstract JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age] PNAS {{doi: 10.1073/pnas.1515386112}} Senescent cells can be targeted for immune clearance, but an ageing immune system likely impairs senescent cell clearance leading to their accumulation.Burton and Faragher (2015). [http://link.springer.com/article/10.1007%2Fs11357-015-9764-2 Cellular senescence: from growth arrest to immunogenic conversion] AGE {{doi:10.1007/s11357-015-9764-2}} Therefore, agents which can enhance immune clearance of senescent cells can also be considered as senotherapeutic.{{cn|date=November 2024}}