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Serglycin

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{{Short description|Protein-coding gene in the species Homo sapiens}}

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Serglycin, also known as hematopoietic proteoglycan core protein or secretory granule proteoglycan core protein, is a protein that in humans is encoded by the SRGN gene.{{cite web | title = Entrez Gene: SRGN serglycin| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5552}} It is primarily expressed in hematopoietic cells and endothelial cells,{{cite journal | vauthors = Kolset SO, Tveit H | title = Serglycin--structure and biology | journal = Cellular and Molecular Life Sciences | volume = 65 | issue = 7–8 | pages = 1073–85 | date = April 2008 | pmid = 18066495 | doi = 10.1007/s00018-007-7455-6 | s2cid = 19422023 | pmc = 11131666 }} and is the only known intracellular proteoglycan.{{cite journal | vauthors = Iozzo RV, Schaefer L | title = Proteoglycan form and function: A comprehensive nomenclature of proteoglycans | journal = Matrix Biology | volume = 42 | pages = 11–55 | date = March 2015 | pmid = 25701227 | pmc = 4859157 | doi = 10.1016/j.matbio.2015.02.003 }}

Function

This gene encodes a protein best known as a hematopoietic cell granule proteoglycan. Proteoglycans stored in the secretory granules of many hematopoietic cells also contain a protease-resistant peptide core, which may be important for neutralizing hydrolytic enzymes. This encoded protein was found to be associated with the macromolecular complex of granzymes and perforin, and serves as a scaffold for the granzyme and perforin in granule-mediated apoptosis.{{Cite journal |last1=Metkar |first1=Sunil S. |last2=Wang |first2=Baikun |last3=Aguilar-Santelises |first3=Miguel |last4=Raja |first4=Srikumar M. |last5=Uhlin-Hansen |first5=Lars |last6=Podack |first6=Eckhard |last7=Trapani |first7=Joseph A. |last8=Froelich |first8=Christopher J. |date=March 2002 |title=Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation |journal=Immunity |volume=16 |issue=3 |pages=417–428 |doi=10.1016/s1074-7613(02)00286-8 |issn=1074-7613 |pmid=11911826|doi-access=free }}

References

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Further reading

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  • {{cite journal | vauthors = Schick BP | title = Regulation of expression of megakaryocyte and platelet proteoglycans | journal = Stem Cells | volume = 14 | pages = 220–31 | year = 2000 | issue = Suppl 1 | pmid = 11012225 | doi = 10.1002/stem.5530140729 | s2cid = 24328770 | doi-access = free }}
  • {{cite journal | vauthors = Humphries DE, Nicodemus CF, Schiller V, Stevens RL | title = The human serglycin gene. Nucleotide sequence and methylation pattern in human promyelocytic leukemia HL-60 cells and T-lymphoblast Molt-4 cells | journal = The Journal of Biological Chemistry | volume = 267 | issue = 19 | pages = 13558–63 | date = July 1992 | doi = 10.1016/S0021-9258(18)42248-X | pmid = 1377686 | doi-access = free }}
  • {{cite journal | vauthors = Nicodemus CF, Avraham S, Austen KF, Purdy S, Jablonski J, Stevens RL | title = Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product | journal = The Journal of Biological Chemistry | volume = 265 | issue = 10 | pages = 5889–96 | date = April 1990 | doi = 10.1016/S0021-9258(19)39446-3 | pmid = 2180935 | doi-access = free }}
  • {{cite journal | vauthors = Mattei MG, Périn JP, Alliel PM, Bonnet F, Maillet P, Passage E, Mattei JF, Jollès P | title = Localization of human platelet proteoglycan gene to chromosome 10, band q22.1, by in situ hybridization | journal = Human Genetics | volume = 82 | issue = 1 | pages = 87–8 | date = April 1989 | pmid = 2714783 | doi = 10.1007/BF00288281 | s2cid = 1378271 }}
  • {{cite journal | vauthors = Avraham S, Stevens RL, Nicodemus CF, Gartner MC, Austen KF, Weis JH | title = Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 10 | pages = 3763–7 | date = May 1989 | pmid = 2726751 | pmc = 287220 | doi = 10.1073/pnas.86.10.3763 | bibcode = 1989PNAS...86.3763A | doi-access = free }}
  • {{cite journal | vauthors = Stellrecht CM, Saunders GF | title = Nucleotide sequence of a cDNA encoding a hemopoietic proteoglycan core protein | journal = Nucleic Acids Research | volume = 17 | issue = 18 | pages = 7523 | date = September 1989 | pmid = 2798108 | pmc = 334837 | doi = 10.1093/nar/17.18.7523 }}
  • {{cite journal | vauthors = Stevens RL, Avraham S, Gartner MC, Bruns GA, Austen KF, Weis JH | title = Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells | journal = The Journal of Biological Chemistry | volume = 263 | issue = 15 | pages = 7287–91 | date = May 1988 | doi = 10.1016/S0021-9258(18)68639-9 | pmid = 2835370 | doi-access = free }}
  • {{cite journal | vauthors = Périn JP, Bonnet F, Maillet P, Jollès P | title = Characterization and N-terminal sequence of human platelet proteoglycan | journal = The Biochemical Journal | volume = 255 | issue = 3 | pages = 1007–13 | date = November 1988 | pmid = 3214420 | pmc = 1135341 | doi = 10.1042/bj2551007}}
  • {{cite journal | vauthors = Avraham S, Stevens RL, Gartner MC, Austen KF, Lalley PA, Weis JH | title = Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue | journal = The Journal of Biological Chemistry | volume = 263 | issue = 15 | pages = 7292–6 | date = May 1988 | doi = 10.1016/S0021-9258(18)68640-5 | pmid = 3366780 | doi-access = free }}
  • {{cite journal | vauthors = Alliel PM, Périn JP, Maillet P, Bonnet F, Rosa JP, Jollès P | title = Complete amino acid sequence of a human platelet proteoglycan | journal = FEBS Letters | volume = 236 | issue = 1 | pages = 123–6 | date = August 1988 | pmid = 3402609 | doi = 10.1016/0014-5793(88)80298-9 | s2cid = 8581282 | doi-access = free }}
  • {{cite journal | vauthors = Hatton MN, Loomis RE, Levine MJ, Tabak LA | title = Masticatory lubrication. The role of carbohydrate in the lubricating property of a salivary glycoprotein-albumin complex | journal = The Biochemical Journal | volume = 230 | issue = 3 | pages = 817–20 | date = September 1985 | pmid = 4062880 | pmc = 1152688 | doi = 10.1042/bj2300817}}
  • {{cite journal | vauthors = Schick BP, Jacoby JA | title = Serglycin and betaglycan proteoglycans are expressed in the megakaryocytic cell line CHRF 288-11 and normal human megakaryocytes | journal = Journal of Cellular Physiology | volume = 165 | issue = 1 | pages = 96–106 | date = October 1995 | pmid = 7559813 | doi = 10.1002/jcp.1041650113 | s2cid = 1455744 }}
  • {{cite journal | vauthors = Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T | title = Construction of a human full-length cDNA bank | journal = Gene | volume = 150 | issue = 2 | pages = 243–50 | date = December 1994 | pmid = 7821789 | doi = 10.1016/0378-1119(94)90433-2 }}
  • {{cite journal | vauthors = Kolset SO, Mann DM, Uhlin-Hansen L, Winberg JO, Ruoslahti E | title = Serglycin-binding proteins in activated macrophages and platelets | journal = Journal of Leukocyte Biology | volume = 59 | issue = 4 | pages = 545–54 | date = April 1996 | pmid = 8613703 | doi = 10.1002/jlb.59.4.545| s2cid = 23125881 }}
  • {{cite journal | vauthors = Toyama-Sorimachi N, Kitamura F, Habuchi H, Tobita Y, Kimata K, Miyasaka M | title = Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 42 | pages = 26714–9 | date = October 1997 | pmid = 9334256 | doi = 10.1074/jbc.272.42.26714 | doi-access = free }}
  • {{cite journal | vauthors = Galvin JP, Spaeny-Dekking LH, Wang B, Seth P, Hack CE, Froelich CJ | title = Apoptosis induced by granzyme B-glycosaminoglycan complexes: implications for granule-mediated apoptosis in vivo | journal = Journal of Immunology | volume = 162 | issue = 9 | pages = 5345–50 | date = May 1999 | doi = 10.4049/jimmunol.162.9.5345 | pmid = 10228010 | doi-access = free }}
  • {{cite journal | vauthors = Schick BP, Gradowski JF, San Antonio JD | title = Synthesis, secretion, and subcellular localization of serglycin proteoglycan in human endothelial cells | journal = Blood | volume = 97 | issue = 2 | pages = 449–58 | date = January 2001 | pmid = 11154222 | doi = 10.1182/blood.V97.2.449 | doi-access = free }}
  • {{cite journal | vauthors = Omtvedt LA, Kolset SO, Thoen J, Førre Y, Gill MR | title = Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseases | journal = Scandinavian Journal of Rheumatology | volume = 30 | issue = 3 | pages = 164–6 | year = 2001 | pmid = 11469527 | doi = 10.1080/030097401300162941 | s2cid = 218854509 }}
  • {{cite journal | vauthors = Metkar SS, Wang B, Aguilar-Santelises M, Raja SM, Uhlin-Hansen L, Podack E, Trapani JA, Froelich CJ | title = Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation | journal = Immunity | volume = 16 | issue = 3 | pages = 417–28 | date = March 2002 | pmid = 11911826 | doi = 10.1016/S1074-7613(02)00286-8 | doi-access = free }}

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Category:Proteoglycans

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