Sesto Campano
{{Infobox Italian comune
| name = Sesto Campano
| official_name = Comune di Sesto Campano
| native_name =
| image_skyline =Panorama_Sesto_Campano.jpg
| imagesize =
| image_alt =
| image_caption = View of Sesto Campano
| image_shield = SestoCampano-Stemma.gif
| shield_alt =
| shield_size = px
| image_map = Map of comune of Sesto Campano (province of Isernia, region Molise, Italy).svg
| map_alt =
| map_caption = Sesto Campano within the Province of Isernia
| pushpin_label_position =
| pushpin_map_alt =
| coordinates = {{coord|41|25|N|14|5|E|type:city(2,863)_region:IT|display=inline,title}}
| coordinates_footnotes =
| region = Molise
| province = Isernia (IS)
| frazioni = Roccapipirozzi
| mayor_party =
| mayor = Luigi Paolone
| area_footnotes =
| area_total_km2 = 36.6
| population_footnotes = All demographics and other statistics: Italian statistical institute Istat.
| population_total = 2387
| population_as_of = 30 September 2016
| pop_density_footnotes =
| population_demonym = Sestolesi
| elevation_footnotes =
| elevation_m =
| twin1 =
| twin1_country =
| saint =
| day =
| postal_code = 86078
| area_code = 0865
| website = {{official website|http://www.comune.sestocampano.is.it/}}
| footnotes =
}}
Sesto Campano is a comune (municipality) in the Province of Isernia in the Italian region Molise, located about {{convert|50|km|mi}} southwest of Campobasso and about {{convert|25|km|mi}} southwest of Isernia.
The municipality is located in the south of its province, close to the borders of Molise with Campania and Lazio. It borders with the municipality Venafro and four others belonging to the Province of Caserta: Ciorlano, Mignano Monte Lungo, Pratella and Presenzano.