Set domain containing 1b

{{Short description|Protein-coding gene in the species Homo sapiens}}

SET domain containing 1B is a protein that in humans is encoded by the SETD1B gene.

{{cite web

| title = Entrez Gene: SET domain containing 1B

| url = https://www.ncbi.nlm.nih.gov/gene/23067

| access-date = 2018-01-13

}}

Function

SET1B is a component of a histone methyltransferase complex that produces trimethylated histone H3 at Lys4 (Lee et al., 2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].

References

{{cite journal |vauthors=Lee JH, Skalnik DG |title=Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation |journal=PLOS ONE |volume=7 |issue=8 |pages=e42965 |year=2012 |pmid=22927943 |pmc=3424240 |doi=10.1371/journal.pone.0042965 |bibcode=2012PLoSO...742965L |doi-access=free }}
{{cite journal |vauthors=Choi YJ, Oh HR, Choi MR, Gwak M, An CH, Chung YJ, Yoo NJ, Lee SH |title=Frameshift mutation of a histone methylation-related gene SETD1B and its regional heterogeneity in gastric and colorectal cancers with high microsatellite instability |journal=Hum. Pathol. |volume=45 |issue=8 |pages=1674–81 |year=2014 |pmid=24925220 |doi=10.1016/j.humpath.2014.04.013 }}
{{cite journal |vauthors=Labonne JD, Lee KH, Iwase S, Kong IK, Diamond MP, Layman LC, Kim CH, Kim HG |title=An atypical 12q24.31 microdeletion implicates six genes including a histone demethylase KDM2B and a histone methyltransferase SETD1B in syndromic intellectual disability |journal=Hum. Genet. |volume=135 |issue=7 |pages=757–71 |year=2016 |pmid=27106595 |doi=10.1007/s00439-016-1668-4 |s2cid=3760488 }}
{{cite journal|last1=Kranz|first1=Andrea|last2=Anastassiadis|first2=Konstantinos|title=The role of SETD1A and SETD1B in development and disease|journal=Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms|volume=1863|issue=8|year=2020|pages=194578|issn=1874-9399|doi=10.1016/j.bbagrm.2020.194578 |pmid=32389824|s2cid=218585660}}
{{cite journal |last1=Brici |first1=David|last2=Zhang|first2=Qinyu |last3=Reinhardt |first3=Susanne|last4=Dahl|first4=Andreas|last5=Hartmann |first5=Hella|last6=Schmidt |first6=Kerstin|last7=Goveas|first7=Neha|last8=Huang|first8=Jiahao |last9=Gahurova|first9=Lenka|last10=Kelsey|first10=Gavin |last11=Anastassiadis|first11=Konstantinos|last12=Stewart|first12=A. Francis|last13=Kranz|first13=Andrea|title=The histone 3 lysine 4 methyltransferase Setd1b is a maternal effect gene required for the oogenic gene expression program|journal=Development|year=2017|volume=144|issue=14|pages=2606–2617|issn=1477-9129|doi=10.1242/dev.143347|pmid=28619824|doi-access=free}}

Set domain containing 1b

Function

References

Further reading