Shivering

Located in the posterior hypothalamus near the wall of the third ventricle is an area called the primary motor center for shivering.{{Citation |last=Bear |first=Matthew H. |title=Neuroanatomy, Hypothalamus |date=2022-10-10 |work=StatPearls [Internet] |url=https://www.ncbi.nlm.nih.gov/sites/books/NBK525993/ |access-date=2025-03-10 |publisher=StatPearls Publishing |language=en |pmid=30252249 |last2=Reddy |first2=Vamsi |last3=Bollu |first3=Pradeep C.}} This area is normally inhibited by signals from the heat center in the anterior hypothalamic-preoptic area but is excited by cold signals from the skin and spinal cord and becomes activated when the body temperature falls even a fraction of a degree below a critical temperature level.{{Cite web |title=Regulation of body temperature by the nervous system |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC6034117/}} The center then causes rapid contractions of skeletal muscles, producing heat as a byproduct.{{Citation |last=McCuller |first=Christopher |title=Physiology, Skeletal Muscle |date=2025 |work=StatPearls |url=https://www.ncbi.nlm.nih.gov/books/NBK537139/ |access-date=2025-03-10 |place=Treasure Island (FL) |publisher=StatPearls Publishing |pmid=30725824 |last2=Jessu |first2=Rishita |last3=Callahan |first3=Avery L.}}

Newborn babies, infants, and young children experience a greater (net) heat loss than adults because of greater surface-area-to-volume ratio. As they cannot shiver to maintain body heat,{{Cite web |title=Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC5684175/}} they rely on non-shivering thermogenesis. Children have an increased amount of brown adipose tissue (increased vascular supply, and high mitochondrial density), and, when cold-stressed, will have greater oxygen consumption and will release norepinephrine.{{Cite journal |last=Gilsanz |first=Vicente |last2=Hu |first2=Houchun H. |last3=Kajimura |first3=Shingo |date=2012-10-22 |title=Relevance of brown adipose tissue in infancy and adolescence |url=https://pmc.ncbi.nlm.nih.gov/articles/PMC3614088/ |journal=Pediatric Research |language=en |volume=73 |issue=1 |pages=3–9 |doi=10.1038/pr.2012.141 |issn=0031-3998 |archive-url=http://web.archive.org/web/20250204141707/https://pmc.ncbi.nlm.nih.gov/articles/PMC3614088/ |archive-date=2025-02-04}} Norepinephrine will react with lipases in brown fat to break down fat into triglycerides.{{Cite journal |last=Zhou |first=Anqiang |last2=Kondo |first2=Mari |last3=Matsuura |first3=Yukinaga |last4=Kameda |first4=Kenji |last5=Morimoto |first5=Chie |last6=Tsujita |first6=Takahiro |last7=Okuda |first7=Hiromichi |date=1995-04-01 |title=Mechanism of norepinephrine-induced lipolysis in isolated adipocytes: evidence for its lipolytic action inside the cells |url=https://www.sciencedirect.com/science/article/abs/pii/092846809500004K |journal=Pathophysiology |volume=2 |issue=1 |pages=29–34 |doi=10.1016/0928-4680(95)00004-K |issn=0928-4680|url-access=subscription }} Triglycerides are then metabolized to glycerol and non-esterified fatty acids.{{Cite web |title=Triglycerides |url=https://eclinpath.com/chemistry/energy-metabolism/triglycerides/ |access-date=2025-03-10 |website=eClinpath |language=en-US}} These are then further degraded in the needed heat-generating process to form CO₂ and water. Chemically, in mitochondria, the proton gradient producing the proton electromotive force that is ordinarily used to synthesize ATP is instead bypassed to produce heat directly.{{Citation |last=Alberts |first=Bruce |title=Electron-Transport Chains and Their Proton Pumps |date=2002 |work=Molecular Biology of the Cell. 4th edition |url=https://www.ncbi.nlm.nih.gov/books/NBK26904/ |access-date=2025-03-10 |publisher=Garland Science |language=en |last2=Johnson |first2=Alexander |last3=Lewis |first3=Julian |last4=Raff |first4=Martin |last5=Roberts |first5=Keith |last6=Walter |first6=Peter}}

Shivering can also appear after surgery. This is known as postanesthetic shivering.

In humans, shivering can also be caused by cognition.Goldstein A. (1980). Thrills in response to music and other stimuli. Physiol. Psychol. 8, 126–129. This is known as psychogenic shivering.Schoeller, F., Eskinazi, M., Garreau, D. (2018) Dynamics of the knowledge instinct: Effects of incoherence on the cognitive system. Cognitive Systems Research 47: 85-91.

Oka, T. (2015). Psychogenic fever: how psychological stress affects body temperature in the clinical population. Temperature: Multidisciplinary Biomedical Journal, 2(3), 368–378. http://doi.org/10.1080/23328940.2015.1056907

The functional capacity of the thermoregulatory system alters with aging, reducing the resistance of elderly people to extreme external temperatures. The shiver response may be greatly diminished or even absent in the elderly, resulting in a significant drop in mean deep body temperature upon exposure to cold. Standard tests of thermoregulatory function show a markedly different rate of decline of thermoregulatory processes in different individuals with ageing.Ring, Francis J. and Phillips, Barbara, Recent Advances in Medical Thermology, pp. 31-33; Springer Publishing, 1984

• Goose bumps
• Myoclonus
• Post micturition convulsion syndrome
• Chattering teeth
• Tremor

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Category:Reflexes