Sign of Hertoghe
{{Short description|Medical sign involving partial eyebrow loss}}
{{Infobox medical condition
| name =
| synonym = Queen Anne's sign
| image = Anne of Denmark in mourning.jpg
| image_size =
| alt =
| caption = Anne of Denmark mourning the death of her son Henry in 1612
| pronounce =
| specialty =
| symptoms =
| complications =
| onset =
| duration =
| types =
| causes = Hypothyroidism, atopic dermatitis
| risks =
| diagnosis =
| prevention =
| treatment =
| medication =
| prognosis =
| frequency =
| deaths =
| named after = Eugene Ludovic Christian Hertoghe
}}
The sign of Hertoghe or Queen Anne's sign is a type of madarosis, more specifically a thinning or loss of the outer third of the eyebrows, and may appear in severe hypothyroidism or atopic dermatitis.{{cite journal |last1=Ständer |first1=Sonja |title=Atopic Dermatitis |journal=New England Journal of Medicine |date=2021-03-25 |volume=384 |issue=12 |pages=1136–1143 |doi=10.1056/NEJMra2023911|pmid=33761208 |s2cid=232355341 }} It was also observed in lepromatous leprosy, secondary syphilis,{{cite journal |last1=Parrino |first1=Daniela |last2=Di Bella |first2=Stefano |date=2016-03-29 |title=Hertoghe sign: an hallmark of lepromatous leprosy |journal=QJM: Monthly Journal of the Association of Physicians |issn=1460-2393 |doi=10.1093/qjmed/hcw046 |pmid=27026695 |volume=109 |issue=7 |pages=497|doi-access=free }}{{Cite journal | last=Sachdeva | first=Silonie | last2=Prasher | first2=Pawan |date=Jan–Feb 2008 |title=Madarosis: A dermatological marker. |url=https://utoronto.scholaris.ca/server/api/core/bitstreams/51c3d7e4-cae1-43ba-9b17-d90ece6773f2/content |journal=Indian Journal of Dermatology, Venereology and Leprology |volume=74 |issue=1 |pages=74 |doi=10.4103/0378-6323.38426 |doi-access=free |pmid=18187839 |hdl=1807/48055 |hdl-access=free }} hypoparathyroidism,{{cite journal |last=Kobylianskii |first=Jane |last2=Gold |first2=Wayne L. |date=2022-02-14 |title=Queen Anne sign |url=https://www.cmaj.ca/content/cmaj/194/6/E219.full.pdf |journal=CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne |volume=194 |issue=6 |page=E219 |doi=10.1503/cmaj.211051 |issn=1488-2329 |pmc=8900800 |pmid=35165135 |access-date=2025-04-03 |doi-access=free}} poisoning with either lead or thallium, lupus, or normal aging.{{Cite journal |last=Tekiner |first=Halil |last2=Yale |first2=Eileen S. |last3=Yale |first3=Steven H. |date=2021-01-01 |title=Eponymous signs in toxicology and poisoning in the nineteenth and early twentieth centuries |url=https://linkinghub.elsevier.com/retrieve/pii/S2214750021001542 |journal=Toxicology Reports |volume=8 |pages=1583–1591 |doi=10.1016/j.toxrep.2021.08.003 |issn=2214-7500 |pmc=8414049 |pmid=34504778}}
Name
The sign is named after the Belgian internist Eugene Ludovic Christian Hertoghe (April 5, 1860–January 3, 1928), who was a native of Antwerp, and was the first pioneer in thyroid function research.{{cite journal |last=Schatz |first=Henry A. |date=May 1922 |title=The Role of the Thyroid Gland in Otolaryngology |journal=The Pennsylvania Medical Journal |volume=25 |issue=8 |pages=529}}{{cite journal |date=April 1914 |title=Complimentary Dinner given by Dr. William Seaman Bainbridge |journal=American Medicine |volume=9 |issue=4 |pages=308 |url=https://books.google.com/books?id=tm4xAQAAMAAJ&dq=complimentary+dinner+given+by+dr.+william+seaman+bainbridge&pg=PA308 |accessdate=2014-12-12}}{{Cite web | url=https://www.genealogieonline.nl/en/van-lerberghe-genealogy/I15024.php | title=Eugène Ludovic Christian Hertoghe (1860-1928) » van Lerberghe genealogy » Genealogy Online}}
__TOC__
= Queen Anne's sign =
The association with Anne of Denmark is based on portraiture, although history does not suggest that she suffered an underactive thyroid.{{cite journal |author=Lane Furdell E |date=May 2007 |title=Eponymous, anonymous: Queen Anne's sign and the misnaming of a symptom |journal=J Med Biogr |pmid=17551609 |doi= 10.1258/j.jmb.2007.06-13|volume=15 |issue=2 |pages=97–101 |s2cid=2474437 }} The eponym is disputed by some,{{Cite journal |last=Tekiner |first=Halil |last2=Yale |first2=Eileen S. |last3=Yale |first3=Steven H. |date=2025-04-15 |title=Removing the Name Queen Anne Sign from the Medical Literature |url=https://www.cmaj.ca/content/removing-name-queen-anne-sign-medical-literature |language=en}} though it has been suggested that Anne of France, Anne of Brittany, Anne of Austria, Anne Boleyn and Anne of Cleves may all be eliminated as candidates.{{cite journal |last=Keynes |first=M |date=February 2009 |title=Letter to the editor |journal=J Med Biogr |pmid=19190203 |doi=10.1258/jmb.2007.007021 |volume=17 |issue=1 |pages=62 |s2cid=207200169 |url=http://jmb.rsmjournals.com/cgi/pmidlookup?view=long&pmid=19190203}}
References
{{reflist}}
{{Thyroid disease}}
Category:Symptoms and signs: Endocrinology, nutrition, and metabolism