Simeticone

{{short description|Anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas}}

{{Missing information|the history of simeticone|date=September 2021}}

{{Drugbox

| Verifiedfields = changed

| verifiedrevid = 417768970

| IUPAC_name = Poly(dimethylsiloxane), silicon dioxide

| image = Simethicone structure.svg

| tradename = Infacol, Wind-eze, WindSetlers, many others

|USAN = simethicone{{cite web|title=Simethicone names|url=https://www.drugs.com/international/simethicone.html|publisher=Drugs.com|access-date=27 August 2017}}

| Drugs.com = {{drugs.com|monograph|simethicone}}

| pregnancy_category = C

| legal_US = OTC

| routes_of_administration = Oral

| bioavailability = None

| protein_bound = 0%

| metabolism = Not metabolized

| elimination_half-life = N/A

| excretion = Feces

| CAS_number_Ref = {{cascite|correct|??}}

| CAS_number = 8050-81-5

| ATC_prefix = A03

| ATC_suffix = AX13

| PubChem = 6433516

| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}

| ChemSpiderID = None

| DrugBank_Ref = {{drugbankcite|correct|drugbank}}

| DrugBank = DB09512

| ChEMBL_Ref = {{ebicite|changed|EBI}}

| ChEMBL = 1200838

| chemical_formula = (C₂H₆OSi)_n · (SiO₂)_m

| molecular_weight = Variable

}}

Simeticone (INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas.

Medical uses

File:Simethiconetablets.jpg

Simeticone is used to relieve the symptoms of excessive gas in the gastrointestinal tract, namely bloating, burping, and flatulence.{{cite web|title=Simethicone tablet|url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d93ff75d-9cdb-476c-bb65-eabeefb91a34|publisher=NIH DailyMed|access-date=27 August 2017|date=April 2016}}{{cite web|title=Simeticone|url=https://www.nhs.uk/medicines/simeticone/|publisher=NHS|language=en|date=10 October 2019|access-date=30 January 2020}} While there is a lack of conclusive evidence that simeticone is effective for this use,⁣{{cite web| vauthors = Modi R, Clearfield HR, Levitt M | title=Belching, Bloating and Flatulence|url=http://patients.gi.org/topics/belching-bloating-and-flatulence/|publisher=American College of Gastroenterology|language=en|date=July 2013}}{{Cite web | url = https://www.drugs.com/monograph/simethicone.html | title = Simethicone | publisher = drugs.com | quote = Efficacy not established for the symptomatic relief of immediate postprandial upper abdominal distress}}{{Failed verification|date=January 2020|reason=Flatulence/bloating and IPPUAD are separate sections in source}} studies have shown that it can relieve symptoms of functional dyspepsia{{cite journal | vauthors = Holtmann G, Gschossmann J, Mayr P, Talley NJ | title = A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia | journal = Alimentary Pharmacology & Therapeutics | volume = 16 | issue = 9 | pages = 1641–8 | date = September 2002 | pmid = 12197843 | doi = 10.1046/j.1365-2036.2002.01322.x | publisher = Wiley | s2cid = 23286985 | doi-access = }} and functional bloating.{{cite journal | vauthors = Burta O, Iacobescu C, Mateescu RB, Nicolaie T, Tiuca N, Pop CS | title = Efficacy and safety of APT036 versus simethicone in the treatment of functional bloating: a multicentre, randomised, double-blind, parallel group, clinical study | journal = Translational Gastroenterology and Hepatology | volume = 3 | issue = 72 | pages = 72 | date = 25 September 2018 | pmid = 30511026 | pmc = 6256934 | doi = 10.21037/tgh.2018.09.11 | publisher = AME Publications | doi-access = free }}

It has not been fully established that simeticone is useful to treat colic in babies,{{cite journal | vauthors = Biagioli E, Tarasco V, Lingua C, Moja L, Savino F | title = Pain-relieving agents for infantile colic | journal = The Cochrane Database of Systematic Reviews | volume = 2016 | pages = CD009999 | date = September 2016 | issue = 9 | pmid = 27631535 | pmc = 6457752 | doi = 10.1002/14651858.CD009999.pub2 }} and it is not recommended for this purpose. A study in the United Kingdom reported that according to parental perception simeticone helped infant colic in some cases.{{cite journal | vauthors = Goldman M, Beaumont T | title = A real world evaluation of a treatment for infant colic based on the experience and perceptions of 4004 parents | journal = British Journal of Nursing | volume = 26 | issue = 5 Suppl 1 | pages = S3–S10 | date = March 2017 | pmid = 28350192 | doi = 10.12968/bjon.2017.26.Sup5.S3 | s2cid = 32885530 }}

Simeticone can also be used for suspected postoperative abdominal discomfort in infants.{{cite journal | vauthors = Voepel-Lewis TD, Malviya S, Burke C, D'Agostino R, Hadden SM, Siewert M, Tait AR | title = Evaluation of simethicone for the treatment of postoperative abdominal discomfort in infants | journal = Journal of Clinical Anesthesia | volume = 10 | issue = 2 | pages = 91–94 | date = March 1998 | pmid = 9524891 | doi = 10.1016/S0952-8180(97)00249-3 }}

Side effects

Simeticone does not have any serious side effects. Two uncommon side effects (occurring in 1 in 100 to 1 in 1,000 patients) are constipation and nausea.{{cite web |title= Simethicone Side Effects in Detail |url=https://www.drugs.com/sfx/simethicone-side-effects.html| work = Drugs.com |access-date=27 August 2017}}

Pharmacology

Simeticone is a non-systemic surfactant which decreases the surface tension of gas bubbles in the GI tract.{{Cite journal| vauthors = Ingold CJ, Akhondi H |date=January 2021|title=Simethicone|url=https://www.ncbi.nlm.nih.gov/books/NBK555997/|journal=StatPearls [Internet].|pmid=32310457 }} This allows gas bubbles to leave the GI tract as flatulence or belching. Simeticone does not reduce or prevent the formation of gas.{{cite web|title=Treatment of Gas|url=https://iffgd.org/symptoms-causes/intestinal-gas/treatment.html|publisher=International Foundation for Functional Gastrointestinal Disorders|language=en-gb|date=4 September 2015}} Its effectiveness has been shown in several in vitro studies.{{cite journal | vauthors = Brecević L, Bosan-Kilibarda I, Strajnar F | title = Mechanism of antifoaming action of simethicone | journal = Journal of Applied Toxicology | volume = 14 | issue = 3 | pages = 207–11 | date = May 1994 | pmid = 8083482 | doi = 10.1002/jat.2550140311 | url = https://www.researchgate.net/publication/15114732 | access-date = 30 January 2020 | publisher = Wiley | s2cid = 7453218 }}{{cite journal | vauthors = Dittrich M, Miederer SE, Havertz B, Krastev R | title = Schaumzerstörung und Schaumverhinderung: Der Wirkmechanismus von Simeticon in vitro |journal= Journal für Gastroenterologische und Hepatologische Erkrankungen. |trans-title=Defoaming and antifoaming action of simethicone in vitro | language = German | date = 12 May 2010 | volume = 8 | issue = 3 | pages = 19–25 | url = https://www.kup.at/kup/pdf/9192.pdf | publisher=Krause & Pachernegg }}

Chemistry

Simeticone is a mixture of dimethicone and silicon dioxide. {{cite encyclopedia |author-link= |veditors = O'Neil MJ |encyclopedia=The Merck Index |title=Dimethicone |edition=14th |year=2006 |publisher=Merck |location=Whitehouse Station, NJ |page=545 }}

Names

The INN name is "simeticone", which was added to the INN recommended list in 1999.{{cite journal|title=Recommended INN List 42|journal=WHO Drug Information|date=1999|volume=13|issue=3|url=https://www.who.int/medicines/publications/druginformation/innlists/RL42.pdf?ua=1|page=202}}

Simeticone is marketed under many brand names and in many combination drugs; it is also marketed as a veterinary drug.{{cite web|title=Simeticone international brands|url=https://www.drugs.com/international/simeticone.html|publisher=Drugs.com|access-date=27 August 2017}}

Brand names include A.F., Acid Off, Aero Red, Aero-OM, Aero-Sim, Aerocol, Aerox, Aesim, Aflat, Air-X, Anaflat, Antiflat, Baby Rest, Bicarsim, Bicarsim Forte, Blow-X, Bobotic, Bobotik, Carbogasol, Colic E, Colin, Cuplaton, Degas, Dentinox, Dermatix, Digesta, Dimetikon Meda, Disflatyl, Disolgas, Elugan N, Elzym, Endo-Paractol, Enterosilicona, Espaven Antigas, Espumisan, Espumisan L, Flacol, Flapex, Flatidyl, Flatoril, Flatulex, Flucolic, Gas X, Gas-X, Gaselab, Gaseoflat, Gaseoflatex, Gaseophar, Gaseoplus, Gaseovet, Gaservol, Gasimetin, Gasnil, Gasofilm, Gastrex, Gastrosen, Gazim X, Gazix, Geludrox-HS, Genasyme, Ilio-Funkton, Imogas, Imogaze, Imonogas, Infacalm, Infacol, Infacolic, Lefax, Lefaxin, Lefoam, Logastin, Luftal, Maxi Flat, Meteosim, Metiorisan, Metsil, Mylanta, Mylicon, Mylicongas, Mylom, Mymus, Nanog, Neodrop, Neogasol, Neolanta, Orocure, Ovol, Pedicon, Phazin, Phazyme, Polysilane Junior, Restime, Rugby Gas Relief, Sab Simplex, Salinal, Semecon, Semeth, Sicongast, Siflat, Silbione, Siligas, Silipin, Sim, Simcone, Simecon, Simecrin, Simedill, Simegut, Simet, Simethicon, Simethicone, Simetic, Simeticon, Simeticona, Simeticone, Siméticone, Simeticonum, Simetigast, Simflat, Simicol, Simicon, Wilcon, Wind-eze and WindSetlers.

It is also marketed as a combination drug:

with algeldrate as Kestomatine
with aluminium or magnesium salts and in some cases both, as Alamag Plus, Almacone, Alposim, Aluphagel, Alutop, Amico-L Andursil, Axcel Eviline, Boots Wind Relief, Di-Gel, Diovol Plus, Diovol Plus AF, Gas Ban DS, Hydrosil, Iosopan Plus, Kremil, Kremil-S, Maalox Plus, Magasida, Mi-Acid, Mygel, Mylagen, Mylanta, Polysilane, Polysilane Delalande, Rumibex and Trial AG
with alverine as Avarin, Meteospasmyl, Nady-Spasmyl
with barium sulfate as Bario Dif
with bismuth as Gastop
with calcium carbonate as Flamints, Gaseoflatex Plus, Malugel, Titralac Plus
with activated charcoal as Carbosylane, Clingest, Finigax. Flatuna
with cinitapride as Rogastril Plus
with clebopride as Flatoril
with dicycloverine as Cloact, Colicspam, Colimix, Colispas, Coliza-D, Cyclopam, Fri-Spas, Meftal Spas, Respas, Simcomine, Spasact, Spasmindon DPS
with domperidone as Bigetric, Dom Simecon, Doprokin-S, Glomoti, Moperidona AF, Mutecium, Praxis
with hydrotalcite as Altacide and Talsil Forte
with homatropine as Aero-Sim Compuesto, Asestor, Factor AG, Sedotropina Flat
with lactulose as Dinolak
with levonorgestrel as Jaydess
with loperamide as Eldoper Plus, Imodium Duo, Imolopesim, Loperamide HCl/Dimeticon, Loperuma, Lositala, Losiwuto, Regulane AF, Stoperan Plus, Toban F Plus
with magaldrate as Aci Basic, Aci-Tip, Acicone-S, Acid-Farvet, Acifin, Amalset, Antiax, Asidrat, Assis, Avicid, Banacid-s, Buenox, Cremalon, Curecid, Digax, Digeril, Endcid, Gaseovet MS, Gastrine, Gastrogel, Gastroral, Gastrorapid, Magacid, Magal-D, Magalat, Magaldrato+Simeticona, Magaldrax, Maganta Plus, Magsilon, Marlox Plus, Megacil Plus, Megalrat Plus, Minicidez, Miopan Plus, Novelta, Oxecone-MS, Riopan Plus, Rolac Plus, Sedo Mag, Simagal, Simelgat Plus, Taimacon, Zymcon
with metoclopramide as Anaflat Compuesto, Di-Aero OM, Digespar, Factorine, Pangastren
with mosapride as M-Pride-MPS, Moxar, Moza MPS
with pancreatin as Anaflat Enzimático, Digenil, Digesflat, Enzym Lefax, Enzymet, Enzymin, fermento duodenal, Finigax Indigestion, Flaton, Flazymec, Gasflat, Gaszym, Gesdyp, Hazmolin, Komflat, MeteoZym, Pankreoflat, Tripanzym
with papaverine as Espasmo Siligas
with pinaverium as Alevian Duo, Pladuet, Planex
with pipenzolate bromide as Cadinol, Gasorbol Gotas
with phloroglucinol as Meteoxane
with trimebutine as Eumotil-S, Eumotrix Plus, Libertrim SDP, Libertrim SII, Muvett S
with urea as Hidribet.

It is also marketed as a veterinary drug under the brands Birp and Methysilox.

References

Category:Antiflatulents

Category:Food additives

Category:Silicon

Category:Silicon dioxide

Category:Digestive system

Category:Silicones