Simon N. Powell

Powell was born on February 13, 1955, in Manchester, England. Powell received the Bachelor of Medicine, Bachelor of Surgery in 1981 from the University of London and went on to complete his Ph.D. there in 1991, holding residencies at Whittington Hospital and Hammersmith Hospital in London{{Cite web|url=http://www.castleconnolly.com/doctors/profiles/simon-n-powell-radiation-oncology/|title=Dr. Simon Powell - Radiation Oncology - New York, NY|website=www.castleconnolly.com|access-date=2018-10-09}} and a fellowship at the Royal Marsden Hospital before being recruited and settling in America.{{cite web|title=Simon Powell to Lead Department of Radiation Oncology| work=Barnes Jewish Hospital|publisher=Washington University School of Medicine in St. Louis |date=July 13, 2004|url=http://www.siteman.wustl.edu/ContentPage.aspx?id=522|archive-url=https://web.archive.org/web/20150905224404/http://www.siteman.wustl.edu/ContentPage.aspx?id=522|archive-date=September 5, 2015|url-status=dead}} Retrieved January 9, 2013

Powell held a fellowship at Harvard Medical School in 1991,{{Cite journal|date=2004-05-07|title=Simon Powell Moving to Head Radiation Oncology at Washington University|journal=Cancer Biology & Therapy|language=en|volume=3|issue=8|pages=699–707|doi=10.4161/cbt.3.8.1108|issn=1538-4047|doi-access=free}} becoming an instructor in 1992, and associate professor of radiation oncology in 1998. He then became clinical director of the Gillette Center for Women's Cancers,{{cite journal|year=2004|title=Awards, Appointments, Announcements|journal=J Natl Cancer Inst |volume=96|issue=16|pages=1203|doi=10.1093/jnci/96.16.1203|doi-access=free}} co-leader of the Harvard Breast Cancer Research Program, and leader of the DNA Repair/Radiation Biology Program. From 2004 to 2008 he served as professor and head of Radiation therapy/radiation oncology at the Washington University School of Medicine in St. Louis.

In 2008, Powell moved to New York to join Memorial Sloan Kettering Cancer Center and become the Chair of the Department of Radiation Oncology in Memorial Hospital{{cite news|url=https://www.nytimes.com/2010/02/26/us/26radiation.html?pagewanted=all&_r=0|title=Radiation Bills Raise Question of Supervision|last=Bogdanich|first=Walt|date=Jan 14, 2013|newspaper=The New York Times|access-date=Feb 25, 2010}} with a joint appointment in Sloan Kettering Institute's Molecular Biology Program.{{cite web|url=http://www2.mskcc.org/gerstner/html/86734.cfm|title=Simon Powell Named Chair of Radiation Oncology|archive-url=https://web.archive.org/web/20151231110243/http://www2.mskcc.org/gerstner/html/86734.cfm|date=2015-12-31|url-status=dead|archive-date=December 31, 2015}} Retrieved January 10, 2013 He was also appointed to the faculties of the Gerstner Sloan Kettering Graduate School of Biomedical Science{{cite web |title=Faculty {{!}} Gerstner Sloan Kettering Graduate School of Biomedical Sciences |url=https://www.sloankettering.edu/gerstner/faculty-research/faculty?title=simon+n+powell |website=www.sloankettering.edu |access-date=5 October 2018 |language=en}} and Weill Cornell Graduate School of Medical Sciences.{{cite web|url=http://weill.cornell.edu/gradschool/faculty/index.html|title=Weill Cornell Graduate School of Medical Sciences, Cornell University, Our Faculty|url-status=dead|archive-url=https://web.archive.org/web/20121222190300/http://weill.cornell.edu:80/gradschool/faculty/index.html|archive-date=December 22, 2012}}{{cite web|publisher=Weill Cornell Graduate School of Medical Sciences, Cornell University|url=http://weill.cornell.edu/gradschool/program/molecular.html|title=Biochemistry & Structural Biology, Cell & Developmental Biology, and Molecular Biology Overview|url-status=dead|archive-url=https://web.archive.org/web/20121118011720/http://weill.cornell.edu:80/gradschool/program/molecular.html|archive-date=November 18, 2012}} He also holds the Enid A. Haupt Chair in Radiation Oncology at the Center.{{Cite web|url=https://www.mskcc.org/cancer-care/doctors/simon-powell|title=Simon N. Powell {{!}} Memorial Sloan Kettering Cancer Center|website=www.mskcc.org|language=en|access-date=2018-10-06}} His career has centered on understanding DNA repair alterations in cancer and how they can be used for the basis of selective cancer therapies. His clinical expertise is in the treatment of breast cancer.{{Cite book|url=https://books.google.com/books?id=xL44oNwJsXgC&q=royal+college+of+physicians+simon+powell&pg=PA141|title=Evolution of Radiation Oncology at Massachusetts General Hospital|last1=Suit|first1=Herman D.|last2=Loeffler|first2=Jay S.|date=2011-02-04|publisher=Springer Science & Business Media|isbn=9781441967442|pages=141|language=en}}

• Fellow of the Royal College of Radiologists of the United Kingdom{{cite web|url=http://radonc.wustl.edu/clinical/powell.html|title=Simon N. Powell, M.D., Ph.D., Department of Radiation Oncology, Chairman|publisher=Washington University School of Medicine|access-date=Jan 14, 2013|url-status=dead|archive-url=https://web.archive.org/web/20160304075220/http://radonc.wustl.edu/clinical/powell.html|archive-date=March 4, 2016}}
• Associate editor, International Journal of Cancer for eight years
• Associate editor, Radiation Research for 5 years[http://www.kumc.edu/rrsnews/archives/2001/2001-2/AnnualReport.htm Radiation Research Society News Annual Report - Radiation Research 2000] Retrieved January 11, 2013
• Editorial board of the Journal of Cancer Biology and Therapy (now the International Journal of Cancer){{cite web|url=http://www.landesbioscience.com/journals/cbt/editorialboard/|title=Landes Bioscience, Cancer Biology & Therapy Journal, Editorial Board|url-status=dead|archive-url=https://web.archive.org/web/20141001052305/http://www.landesbioscience.com:80/journals/cbt/editorialboard/|archive-date=October 1, 2014}}
• Member, American Association for Cancer Research{{cite journal|last1=Lok|first1=BH|last2=Powell|first2=SN|title=Molecular Pathways: Understanding the Role of Rad52 in Homologous Recombination for Therapeutic Advancement|url= |journal=Clinical Cancer Research|publisher=American Association for Cancer Research|volume=18|issue=23|pages=6400–6406|doi=10.1158/1078-0432.CCR-11-3150|pmc=3513650|pmid=23071261|year=2012}} P. 7
• Member, Radiation Research Society{{cite web|url=http://www.radres.org/ECOMradres/timssnet/RadeFTP/RRS_2010_Abstract.pdf|title=56th Annual Meeting, Radiation Research Society, Oceans of Opportunity|work=Synthetic Lethality and Repair Targeting: New Opportunities for Treatment|publisher=Radiation Research Society|access-date=Jan 14, 2013|url-status=dead|archive-url=https://web.archive.org/web/20120515100013/http://www.radres.org/ECOMradres/timssnet/RadeFTP/RRS_2010_Abstract.pdf|archive-date=May 15, 2012}}

• Fellow of the American Society for Radiation Oncology (FASTRO) 2014{{Cite web|url=https://www.astro.org/About-ASTRO/Recognition-Awards/Fellow-Recipients|title=Fellow Recipients - American Society for Radiation Oncology (ASTRO) - American Society for Radiation Oncology (ASTRO)|website=ASTRO|access-date=2018-10-06}}
• European Society for Theapeutic Radiology and Oncology (E.S.T.R.O.) Varian Award (1990){{cite web|url=http://www.estro.org/about/Pages/estroorgaboutPagesESTROAwardsVarian.aspx|title=ESTRO - Varian Research Award|work=Clonal variation of DNA repair in a human glioma cell line|publisher=Institute of Cancer Research, Sutton, Surrey, UK|access-date=Jan 14, 2013|url-status=dead|archive-url=https://web.archive.org/web/20120330231132/http://www.estro.org/about/Pages/estroorgaboutPagesESTROAwardsVarian.aspx|archive-date=March 30, 2012}}

• {{cite journal |pmid=7712468 |year=1995 |last1=Powell |first1=Simon N. |last2=Defrank |first2=Jeffrey S. |last3=Connell |first3=Paul |last4=Eogan |first4=Maeve |last5=Preffer |first5=Frederic |last6=Dombkowski |first6=David |last7=Tang |first7=Wei |last8=Friend |first8=Stephen |title=Differential sensitivity of p53^(-) and p53⁽⁺⁾ cells to caffeine-induced radiosensitization and override of G2 delay |volume=55 |issue=8 |pages=1643–8 |journal=Cancer Research |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=7712468}}
• {{cite journal|pages=1847–57|doi=10.1038/sj.onc.1201143|title=Inactivation of p53 results in high rates of homologous recombination|year=1997|last1=Mekeel|first1=Kristin L|last2=Tang|first2=Wei|last3=Kachnic|first3=Lisa A|last4=Luo|first4=Chen-Mei|last5=Defrank|first5=Jeffrey S|last6=Powell|first6=Simon N|journal=Oncogene|volume=14|issue=15|pmid=9150391|s2cid=25122282}}
• {{cite journal|pages=8644–9|doi=10.1073/pnas.151253498|pmc=37489|title=Deficiency of human BRCA2 leads to impaired homologous recombination but maintains normal nonhomologous end joining|last7=Powell|first7=S.N.|year=2001|last1=Xia|first1=F.|last2=Taghian|first2=D.G.|last3=DeFrank|first3=J.S.|last4=Zeng|first4=Z.C.|last5=Willers|first5=H.|last6=Iliakis|first6=G.|journal=Proceedings of the National Academy of Sciences|volume=98|issue=15|pmid=11447276|bibcode=2001PNAS...98.8644X|doi-access=free}}
• {{cite journal |pmid=14701743 |year=2004 |last1=Zhang |first1=J |last2=Willers |first2=H |last3=Feng |first3=Z |last4=Ghosh |first4=JC |last5=Kim |first5=S |last6=Weaver |first6=DT |last7=Chung |first7=JH |last8=Powell |first8=SN |last9=Xia |first9=F |title=Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair |volume=24 |issue=2 |pages=708–18 |pmc=343805 |journal=Molecular and Cellular Biology |doi=10.1128/MCB.24.2.708-718.2004}}
• {{cite journal |pages=9025–33 |doi=10.1038/sj.onc.1207982 |title=The interaction of p53 with replication protein a mediates suppression of homologous recombination |year=2004 |last1=Romanova |first1=Larisa Y |last2=Willers |first2=Henning |last3=Blagosklonny |first3=Mikhail V |last4=Powell |first4=Simon N |journal=Oncogene |volume=23 |issue=56 |pmid=15489903|doi-access= }}
• {{cite journal |pages=255–65 |doi=10.1016/j.ccr.2005.08.004 |title=BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ |year=2005 |last1=Litman |first1=Rachel |last2=Peng |first2=Min |last3=Jin |first3=Zhe |last4=Zhang |first4=Fan |last5=Zhang |first5=Junran |last6=Powell |first6=Simon |last7=Andreassen |first7=Paul R. |last8=Cantor |first8=Sharon B. |journal=Cancer Cell |volume=8 |issue=3 |pmid=16153896|doi-access=free }}
• {{cite journal |pages=902–9 |doi=10.1038/nsmb991 |title=MDC1 interacts with Rad51 and facilitates homologous recombination |year=2005 |last1=Zhang |first1=Junran |last2=Ma |first2=Zhefu |last3=Treszezamsky |first3=Alejandro |last4=Powell |first4=Simon N |journal=Nature Structural & Molecular Biology |volume=12 |issue=10 |pmid=16186822|s2cid=24097999 }}
• {{cite journal |pages=686–91 |doi=10.1073/pnas.1010959107 |title=Rad52 inactivation is synthetically lethal with BRCA2 deficiency |year=2010 |last1=Feng |first1=Z. |last2=Scott |first2=S. P. |last3=Bussen |first3=W. |last4=Sharma |first4=G. G. |last5=Guo |first5=G. |last6=Pandita |first6=T. K. |last7=Powell |first7=S. N. |journal=Proceedings of the National Academy of Sciences |volume=108 |issue=2 |pmid=21148102 |pmc=3021033|doi-access=free }}
• {{cite journal |pages=668–72 |doi=10.1038/ng.855 |title=The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma |year=2011 |last1=Bott |first1=Matthew |last2=Brevet |first2=Marie |last3=Taylor |first3=Barry S |last4=Shimizu |first4=Shigeki |last5=Ito |first5=Tatsuo |last6=Wang |first6=Lu |last7=Creaney |first7=Jenette |last8=Lake |first8=Richard A |last9=Zakowski |first9=Maureen F | display-authors=8 |journal=Nature Genetics |volume=43 |issue=7 |pmid=21642991|pmc=4643098 }}
• {{cite journal |last1=Riaz |first1=N |last2=Blecua |first2=P |last3=Lim |first3=RS |last4=Shen |first4=R |last5=Higginson |first5=DS |last6=Weinhold |first6=N |last7=Norton |first7=L |last8=Weigelt |first8=B |last9=Powell |first9=SN |last10=Reis-Filho |first10=JS |title=Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes. |journal=Nature Communications |date=11 October 2017 |volume=8 |issue=1 |pages=857 |doi=10.1038/s41467-017-00921-w |pmid=29021619|pmc=5636842 |bibcode=2017NatCo...8..857R }}
• {{cite journal |last1=Bakhoum |first1=SF |last2=Ngo |first2=B |last3=Laughney |first3=AM |last4=Cavallo |first4=JA |last5=Murphy |first5=CJ |last6=Ly |first6=P |last7=Shah |first7=P |last8=Sriram |first8=RK |last9=Watkins |first9=TBK |last10=Taunk |first10=NK |last11=Duran |first11=M |last12=Pauli |first12=C |last13=Shaw |first13=C |last14=Chadalavada |first14=K |last15=Rajasekhar |first15=VK |last16=Genovese |first16=G |last17=Venkatesan |first17=S |last18=Birkbak |first18=NJ |last19=McGranahan |first19=N |last20=Lundquist |first20=M |last21=LaPlant |first21=Q |last22=Healey |first22=JH |last23=Elemento |first23=O |last24=Chung |first24=CH |last25=Lee |first25=NY |last26=Imielenski |first26=M |last27=Nanjangud |first27=G |last28=Pe'er |first28=D |last29=Cleveland |first29=DW |last30=Powell |first30=SN |last31=Lammerding |first31=J |last32=Swanton |first32=C |last33=Cantley |first33=LC |title=Chromosomal instability drives metastasis through a cytosolic DNA response. |journal=Nature |date=25 January 2018 |volume=553 |issue=7689 |pages=467–472 |doi=10.1038/nature25432 |pmid=29342134|pmc=5785464 |bibcode=2018Natur.553..467B }}

{{Reflist}}

{{Refbegin}}

• Publications: [http://www.mskcc.org/mskcc/html/87900.cfm Simon N. Powell's Publications]
• Pubmed: [https://www.ncbi.nlm.nih.gov/sites/entrez?cmd=search&db=pubmed&term=Powell%20SN%5bAU%5d%20OR%20(Powell%20S%5bAU%5d%20AND%20(DNA%20Repair%20OR%20Breast%20%20Cancer))%20NOT%20Singleton%20D%5bAU%5d Simon N. Powell's Journal Articles]
• [https://web.archive.org/web/20130107050808/http://www.mskcc.org/magazine/december-2009/interview-simon-powell An Interview with Simon Powell]{{Refend}}

{{DEFAULTSORT:Powell, Simon N.}}

Category:1955 births

Category:Living people

Category:Alumni of the University of London

Category:Health professionals from Manchester

Category:English emigrants to the United States

Category:Cancer researchers

Category:Washington University School of Medicine faculty

Category:Alumni of the University of Oxford

Category:Harvard Medical School faculty