Simple Modular Architecture Research Tool

{{short description|Biological database}}

{{primary sources|date=September 2015}}

{{infobox biodatabase

|title = SMART

|logo =

|description = Identification scheme for protein domains.

|scope = Protein domains

|organism = all

|center = European Molecular Biology Laboratory

|laboratory =

|author =

|pmid = 18978020

|released =

|standard =

|format =

|url = http://smart.embl-heidelberg.de

|download =

|webservice =

|sql =

|sparql =

|webapp =

|standalone =

|license = Free to academics, but not commercial users

|versioning =

|frequency =

|curation = Yes

|bookmark =

|version = 7

}}

Simple Modular Architecture Research Tool (SMART) is a biological database that is used in the identification and analysis of protein domains within protein sequences.{{cite journal |vauthors=Schultz J, Milpetz F, Bork P, Ponting CP | title = SMART, a simple modular architecture research tool: identification of signaling domains | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 11 | pages = 5857–64 |date=May 1998 | pmid = 9600884 | pmc = 34487 | doi = 10.1073/pnas.95.11.5857| bibcode = 1998PNAS...95.5857S | url = http://www.pnas.org/content/95/11/5857.full.pdf| doi-access = free }}{{cite journal |vauthors=Letunic I, Doerks T, Bork P | title = SMART 6: recent updates and new developments | journal = Nucleic Acids Res. | volume = 37 | issue = Database issue | pages = D229–32 |date=January 2009 | pmid = 18978020 | pmc = 2686533 | doi = 10.1093/nar/gkn808 }} SMART uses profile-hidden Markov models built from multiple sequence alignments to detect protein domains in protein sequences. The most recent release of SMART contains 1,204 domain models.{{Cite journal|last1=Letunic|first1=Ivica|last2=Doerks|first2=Tobias|last3=Bork|first3=Peer|date=January 2015|title=SMART: recent updates, new developments and status in 2015|journal=Nucleic Acids Research|volume=43|issue=Database issue|pages=D257–260|doi=10.1093/nar/gku949|issn=1362-4962|pmc=4384020|pmid=25300481}} Data from SMART was used in creating the Conserved Domain Database collection and is also distributed as part of the InterPro database.{{cite journal |vauthors=Mulder NJ, Apweiler R, Attwood TK, etal |title=InterPro: an integrated documentation resource for protein families, domains and functional sites |journal=Brief. Bioinformatics |volume=3 |issue=3 |pages=225–35 |date=September 2002 |pmid=12230031 |doi= 10.1093/bib/3.3.225|doi-access=free }} The database is hosted by the European Molecular Biology Laboratory in Heidelberg.