Sirio

Sirio may refer to:

• Sirio (album), 2022 album by Lazza
• Sirio Carrapa (born 1952), Italian mystic
• Sirio Maccioni (1932–2020), restaurateur and author based in New York City
• {{MV|Sirio}}, a Maltese and Panamanian train ferry
• {{SS|Sirio}}, an Italian immigrant transporter ship, wrecked off Cartagena in 1906
• Sirio, a brand of engines by Italian American Motor Engineering
• Hitachi Sirio is a low-floor tram built by Ansaldobreda
• Lake Sirio, lake in northern Italy
• Sirio-class patrol vessel
• Sirio-class torpedo boat