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Small-blue-round-cell tumor

{{short description|Cancerous tumors composed of small cells which stain blue}}

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In histopathology, a small-blue-round-cell tumour (abbreviated SBRCT), also known as a small-round-blue-cell tumor (SRBCT) or a small-round-cell tumour (SRCT), is any one of a group of malignant neoplasms that have a characteristic appearance under the microscope, i.e. consisting of small round cells that stain blue on routine H&E stained sections.

These tumors are seen more often in children than in adults. They typically represent undifferentiated cells. The predominance of blue staining is because the cells consist predominantly of nucleus, thus they have scant cytoplasm.{{cite journal | vauthors = Gregorio A, Corrias MV, Castriconi R, Dondero A, Mosconi M, Gambini C, Moretta A, Moretta L, Bottino C | display-authors = 6 | title = Small round blue cell tumours: diagnostic and prognostic usefulness of the expression of B7-H3 surface molecule | journal = Histopathology | volume = 53 | issue = 1 | pages = 73–80 | date = July 2008 | pmid = 18613926 | pmc = 2658025 | doi = 10.1111/j.1365-2559.2008.03070.x }}{{cite journal| vauthors = Khan J, Wei J, Saal L, Marc L, Markus R, Peterson C, Chen Y, Meltzer P |title=Development of a molecular taxonomy of small blue round-cell tumors using cDNA microarrays|journal=Nature Genetics|date=April 2001|volume=27|issue=4s|pages=64|doi=10.1038/87150|doi-access=free}}

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Examples

Tumors that belong to this group are:

  • Desmoplastic small-round-cell tumour
  • Ewing sarcoma/PNET{{cite journal | vauthors = Chen QR, Vansant G, Oades K, Pickering M, Wei JS, Song YK, Monforte J, Khan J | display-authors = 6 | title = Diagnosis of the small round blue cell tumors using multiplex polymerase chain reaction | journal = The Journal of Molecular Diagnostics | volume = 9 | issue = 1 | pages = 80–8 | date = February 2007 | pmid = 17251339 | pmc = 1867426 | doi = 10.2353/jmoldx.2007.060111 | url = http://jmd.amjpathol.org/cgi/pmidlookup?view=long&pmid=17251339 }}{{cite journal | vauthors = Grünewald TG, Cidre-Aranaz F, Surdez D, Tomazou EM, de Álava E, Kovar H, Sorensen PH, Delattre O, Dirksen U | s2cid = 49571421 | display-authors = 6 | title = Ewing sarcoma | language = En | journal = Nature Reviews. Disease Primers | volume = 4 | issue = 1 | pages = 5 | date = July 2018 | pmid = 29977059 | doi = 10.1038/s41572-018-0003-x }}
  • Neuroblastoma
  • Medulloblastoma
  • Rhabdomyosarcoma
  • Synovial sarcoma
  • Carcinoid tumor
  • Mesothelioma
  • Small cell lung cancer
  • Wilms' tumour
  • Retinoblastoma{{cite journal |last1=Akhtar |first1=K |last2=Waris |first2=A |title=Ocular retinoblastoma and neuroblastoma: A cytological impression |journal=J Surg Med |date=2018 |volume=3 |issue=2 |pages=391-395 |url=https://jsurgmed.com/article/download/430299/5207 |access-date=4 April 2025}}
  • Small-cell lymphoma
  • Hepatoblastoma- only the anaplastic form has round blue cells, the more common fetal and embryonal types do not Gray W, Kocjan G. Diagnostic Cytopathology; . p.307
  • Merkel cell carcinoma
  • Mesenchymal chondrosarcoma

Conditions mimicking SBRCT

Image:Endometrial stromal condensation high mag.jpg

Endometrial stromal condensation may mimic a small-blue-round-cell tumour.

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References

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