Sodium in biology#Humans

{{See also|Halotolerance}}

The minimum physiological requirement for sodium is between 115 and 500 mg per day depending on sweating due to physical activity, and whether the person is adapted to the climate.{{cite book

|author=National Research Council (US) Subcommittee on the Tenth Edition of the Recommended Dietary Allowances

|editor=National Academies Press (US)

|title=Recommended Dietary Allowances

|year=1989

|publisher=National Academies Press (US)

|chapter=10

|doi=10.17226/1349

|pmid=25144070

|quote=Thus, a minimum average requirement for adults can be estimated under conditions of maximal adaptation and without active sweating as no more than 5 mEq/day, which corresponds to 115 mg of sodium or approximately 300 mg of sodium chloride per day. In consideration of the wide variation of patterns of physical activity and climatic exposure, a safe minimum intake might be set at 500 mg/day. [Note: Table 11-1 seems to clarify that 500 mg refers to sodium, not sodium chloride]

|isbn=978-0-309-04633-6

|url-access=registration

|url=https://archive.org/details/recommendeddieta0000nati

}} Sodium chloride is the principal source of sodium in the diet, and is used as seasoning and preservative, such as for pickling and jerky; most of it comes from processed foods.{{cite web|url=http://health.ltgovernors.com/sodium-and-potassium-health-facts.html|title=Sodium and Potassium Quick Health Facts|access-date=7 November 2011}} The Adequate Intake for sodium is 1.2 to 1.5 g per day,{{cite book|title=Dietary Reference Intakes: Water, Potassium, Sodium, Chloride, and Sulfate|url=https://www.nap.edu/read/10925/chapter/1|publisher=Food and Nutrition Board, Institute of Medicine, United States National Academies|date=2005|doi=10.17226/10925 |isbn=978-0-309-09169-5 |access-date=21 October 2016}} but on average people in the United States consume 3.4 g per day,{{cite book|author1=U.S. Department of Agriculture|author2=U.S. Department of Health and Human Services|author-link1=United States Department of Agriculture|author-link2=United States Department of Health and Human Services|title=Dietary Guidelines for Americans, 2010|page=22|edition=7th|date=December 2010|publisher=U.S. Government Printing Office |url=http://www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/PolicyDoc/PolicyDoc.pdf|access-date=2011-11-23|isbn=978-0-16-087941-8|oclc=738512922|url-status=dead|archive-url=https://web.archive.org/web/20110206111821/http://www.cnpp.usda.gov/Publications/DietaryGuidelines/2010/PolicyDoc/PolicyDoc.pdf|archive-date=2011-02-06}} the minimum amount that promotes hypertension.{{cite journal|pmid=15369026|year=2004|last1=Geleijnse|first1=J. M.|last2=Kok|first2=F. J.|last3=Grobbee|first3=D. E.|title=Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations|volume=14|issue=3|pages=235–239|journal=European Journal of Public Health|doi=10.1093/eurpub/14.3.235|doi-access=free}} Note that salt contains about 39.3% sodium by mass[https://books.google.com/books?id=bcU8AAAAQBAJ&pg=PA48 General, Organic, and Biochemistry: An Applied Approach]{{--}}the rest being chlorine and other trace chemicals; thus the Tolerable Upper Intake Level of 2.3 g sodium would be about 5.9 g of salt—about 1 teaspoon.[http://www.traditionaloven.com/culinary-arts/cooking/table-salt/convert-gram-g-to-tea-spoon-tsp.html Table Salt Conversion] The average daily excretion of sodium is between 40 and 220 mEq.{{Cite web |title=Sodium - Urine |url=https://www.ucsfhealth.org/Medical%20Tests/003599 |access-date=2022-04-29 |website=ucsfhealth.org |language=en}}

Normal serum sodium levels are between approximately 135 and 145 mEq/L (135 to 145 mmol/L). A serum sodium level of less than 135 mEq/L qualifies as hyponatremia, which is considered severe when the serum sodium level is below 125 mEq/L.{{cite web|url=http://www.mayoclinic.com/health/hyponatremia/DS00974 |title=Hyponatremia |publisher=MayoClinic.com |access-date=2010-09-01}}{{cite web|url=http://emedicine.medscape.com/article/242166-overview |title=Hyponatremia |publisher=Medscape |access-date=2013-06-30}}

The renin–angiotensin system and the atrial natriuretic peptide indirectly regulate the amount of signal transduction in the human central nervous system, which depends on sodium ion motion across the nerve cell membrane, in all nerves. Sodium is thus important in neuron function and osmoregulation between cells and the extracellular fluid; the distribution of sodium ions are mediated in all animals by sodium–potassium pumps, which are active transporter solute pumps, pumping ions against the gradient, and sodium-potassium channels.{{cite book|last=Campbell|first=Neil|title=Biology|year=1987|isbn=0-8053-1840-2|page=795|publisher=Benjamin/Cummings}} Sodium channels are known to be less selective in comparison to potassium channels. Sodium is the most prominent cation in extracellular fluid: in the 15 L of extracellular fluid in a 70 kg human there is around 50 grams of sodium, 90% of the body's total sodium content.

Some potent neurotoxins, such as batrachotoxin, increase the sodium ion permeability of the cell membranes in nerves and muscles, causing a massive and irreversible depolarization of the membranes with potentially fatal consequences. However, drugs with smaller effects on sodium ion motion in nerves may have diverse pharmacological effects that range from anti-depressant to anti-seizure actions.

Since only some plants need sodium and those in small quantities, a completely plant-based diet will generally be very low in sodium.{{Citation needed|date=November 2018}} This requires some herbivores to obtain their sodium from salt licks and other mineral sources. The animal need for sodium is probably the reason for the highly conserved ability to taste the sodium ion as "salty." Receptors for the pure salty taste respond best to sodium; otherwise, the receptors respond only to a few other small monovalent cations ({{chem2|Li+}}, {{chem2|NH4+}} and somewhat to {{chem2|K+}}). The calcium ion (Ca²⁺) also tastes salty and sometimes bitter to some people but, like potassium, can trigger other tastes.

Sodium ions play a diverse and important role in many physiological processes, acting to regulate blood volume, blood pressure, osmotic equilibrium and pH.{{cite web | url=https://sodiumbreakup.heart.org/how_much_sodium_should_i_eat | title=How much sodium should I eat per day? | publisher=American Heart Association | date=2016 | access-date=21 October 2016}}

{{See also|Soil salinity control|Salt tolerance of crops|Halophyte|Crop tolerance to seawater}}

In C4 plants, sodium is a micronutrient that aids in metabolism, specifically in regeneration of phosphoenolpyruvate (involved in the biosynthesis of various aromatic compounds, and in carbon fixation) and synthesis of chlorophyll.{{cite web|last=Kering|first=M. K.|url=https://mospace.umsystem.edu/xmlui/bitstream/handle/10355/7201/research.pdf?sequence=3|title=Manganese Nutrition and Photosynthesis in NAD-malic enzyme C4 plants Ph.D. dissertation|publisher=University of Missouri-Columbia|year=2008|access-date=2011-11-09}} In others, it substitutes for potassium in several roles, such as maintaining turgor pressure and aiding in the opening and closing of stomata.{{cite journal|last1=Subbarao|first1=G. V.|last2=Ito|first2=O.|last3=Berry|first3=W. L.|last4=Wheeler|first4=R. M.|title=Sodium—A Functional Plant Nutrient|journal=Critical Reviews in Plant Sciences| volume=22| pages=391–416| year=2003|doi=10.1080/07352680390243495|issue=5|s2cid=85111284 }} Excess sodium in the soil limits the uptake of water due to decreased water potential, which may result in wilting; similar concentrations in the cytoplasm can lead to enzyme inhibition, which in turn causes necrosis and chlorosis.{{cite journal| last1=Zhu|first1=J. K.|title=Plant salt tolerance|journal=Trends in Plant Science|volume=6|issue=2|pages=66–71|year=2001|pmid=11173290|doi=10.1016/S1360-1385(00)01838-0}} To avoid these problems, plants developed mechanisms that limit sodium uptake by roots, store them in cell vacuoles, and control them over long distances;{{cite web|url=http://www.plant-biology.com/salt-ion-toxicity.php|title=Plants and salt ion toxicity|publisher=Plant Biology|access-date=2010-11-02}} excess sodium may also be stored in old plant tissue, limiting the damage to new growth. Though much how excess sodium loading in the xylem is yet to be determined. However, anti porter CHX21 can be attributed to active loading of sodium into the xylem.{{Cite journal |last=Maathuis |first=Frans J. M. |date=2014-03-01 |title=Sodium in plants: perception, signalling, and regulation of sodium fluxes |journal=Journal of Experimental Botany |volume=65 |issue=3 |pages=849–858 |doi=10.1093/jxb/ert326 |pmid=24151301 |issn=0022-0957|doi-access=free }}

Sodium is the primary cation (positively charged ion) in extracellular fluids in animals and humans. These fluids, such as blood plasma and extracellular fluids in other tissues, bathe cells and carry out transport functions for nutrients and wastes. Sodium is also the principal cation in seawater, although the concentration there is about 3.8 times what it is normally in extracellular body fluids.

{{main|Hyponatremia|Hypernatremia|Diuretic|Vasopressin}}

Although the system for maintaining optimal salt and water balance in the body is a complex one,{{cite book

|last1=Clausen |first1=Michael Jakob Voldsgaard |last2=Poulsen |first2=Hanne

|editor1-first=Lucia|editor1-last=Banci |series=Metal Ions in Life Sciences |volume=12

|pages=41–67 |chapter= Chapter 3 Sodium/Potassium Homeostasis in the Cell

|title=Metallomics and the Cell |year=2013 |publisher=Springer |isbn=978-94-007-5560-4|doi=10.1007/978-94-007-5561-1_3|pmid=23595670 }} electronic-book {{ISBN|978-94-007-5561-1}} {{issn|1559-0836}} electronic-{{issn|1868-0402}}

one of the primary ways in which the human body keeps track of loss of body water is that osmoreceptors in the hypothalamus sense a balance of sodium and water concentration in extracellular fluids. Relative loss of body water will cause sodium concentration to rise higher than normal, a condition known as hypernatremia. This ordinarily results in thirst. Conversely, an excess of body water caused by drinking will result in too little sodium in the blood (hyponatremia), a condition which is again sensed by the hypothalamus, causing a decrease in vasopressin hormone secretion from the posterior pituitary, and a consequent loss of water in the urine, which acts to restore blood sodium concentrations to normal.

Severely dehydrated persons, such as people rescued from ocean or desert survival situations, usually have very high blood sodium concentrations. These must be very carefully and slowly returned to normal, since too-rapid correction of hypernatremia may result in brain damage from cellular swelling, as water moves suddenly into cells with high osmolar content.

In humans, a high-salt intake was demonstrated to attenuate nitric oxide production. Nitric oxide (NO) contributes to vessel homeostasis by inhibiting vascular smooth muscle contraction and growth, platelet aggregation, and leukocyte adhesion to the endothelium.{{cite journal | title = Relationship between Salt Intake, Nitric Oxide and Asymmetric Dimethylarginine and Its Relevance to Patients with End-Stage Renal Disease − |author1=Tomohiro Osanai |author2=Naoto Fujiwara |author3=Masayuki Saitoh |author4=Satoko Sasaki |author5=Hirofumi Tomita |author6=Masayuki Nakamura |author7=Hiroshi Osawa |author8=Hideaki Yamabe |author9=Ken Okumura | journal = Blood Purif | year = 2002 | volume = 20 |issue=5 | pages = 466–468 | doi = 10.1159/000063555 | pmid=12207094|s2cid=46833231 }}

Because the hypothalamus/osmoreceptor system ordinarily works well to cause drinking or urination to restore the body's sodium concentrations to normal, this system can be used in medical treatment to regulate the body's total fluid content, by first controlling the body's sodium content. Thus, when a powerful diuretic drug is given which causes the kidneys to excrete sodium, the effect is accompanied by an excretion of body water (water loss accompanies sodium loss). This happens because the kidney is unable to efficiently retain water while excreting large amounts of sodium. In addition, after sodium excretion, the osmoreceptor system may sense lowered sodium concentration in the blood and then direct compensatory urinary water loss in order to correct the hyponatremic (low blood sodium) state.

File:Hand drawn sodium-potassium pump and ion channels..png

The sodium-potassium pump works with the sodium and potassium leak channels to maintain the membrane potential between the cell and the extracellular space. Sodium moves down the concentration gradient from the cytosol into the extracellular matrix. Potassium moves down its concentration gradient from the extracellular matrix into the cytosol. In order to maintain the membrane potential, the sodium-potassium pump acts as a form of direct active transport where the hydrolysis of ATP to ADP and an inorganic phosphate at the P-type ATPase moves 3 potassium ions back out of the cell and 2 sodium ions into the cell.{{Cite book |last1=Alberts |first1=B |title=Essential Cell Biology |last2=Hopkin |first2=K |last3=Johnson |first3=A |last4=Morgan |first4=D |last5=Raff |first5=M |publisher=Pearson |year=2019 |edition=5th}}

The sodium-potassium pump plays a large role in neural signaling due to the maintenance of cell membrane potential. This creates an action potential that causes the neurons to polarize and depolarize their membranes by opening and closing the voltage gated channels: this alters voltage potential and leads to neurotransmitter secretion and ultimately signal transmission.Ma, Yunyan. "The Significance of Sodium-Potassium Pump (Na⁺, K⁺-ATPase) in Neural Signaling." Highlights in Science, Engineering and Technology 66 (2023): 208-212.

When the pump fails to function, patients are susceptible to illnesses like heart failure and chronic obstructive lung disease (COLD). Those who experienced an event of heart failure had on average, a 40% lower concentration of the sodium-potassium ATPase. This lack of polarization of the membrane leads to an inability of action potentials to propagate at their usual rate, leading to a lowered hear rate and potentially heart failure.Pirahanchi Y, Jessu R, Aeddula NR. Physiology, Sodium Potassium Pump. [Updated 2023 Mar 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537088/ In COLD diagnoses, a majority of patients found to have a lowered amount of magnesium and potassium also had a decreased concentration of the sodium-potassium pump in skeletal and smooth muscle during respiratory failure. COLD is treatable in the short term by glucocorticoid which up-regulates the sodium-potassium pump, helping to support muscle endurance and increase muscle activity during these episodes of respiratory failure.{{Cite journal |last1=Ravn |first1=H. B. |last2=DøRup |first2=I. |date=2003 |title=The concentration of sodium,potassium pumps in chronic obstructive lung disease (COLD) patients: the impact of magnesium depletion and steroid treatment |url=https://onlinelibrary.wiley.com/doi/10.1046/j.1365-2796.1997.69891000.x |journal=Journal of Internal Medicine |language=en |volume=241 |issue=1 |pages=23–29 |doi=10.1046/j.1365-2796.1997.69891000.x |pmid=9042090 |s2cid=28561998 |issn=0954-6820|url-access=subscription }}

File:Conformational changes of the sodium-glucose symporter.png

In the sodium-glucose symporter, sodium moves down its concentration gradient to move glucose up its concentration gradient. Sodium has a greater concentration outside of the cell, and binds to the symporter, which is in its outward facing conformation. Once sodium is bound, glucose can bind from the extracellular space, causing the symporter to switch into the occluded formation (closed) before opening to the inside of the cell and releasing the two sodium ions and the one glucose molecule. Once both are released, the symporter re-orients itself to the outward facing conformation and the process starts all over again. A major example of up-regulation of the sodium-glucose symporter is seen in patients with type 2 diabetes, where there is roughly a 3-4 fold up-regulation of the sodium-glucose symporter (SGLT1). This leads to an influx of glucose into the cell and results in hyperglycemia.{{Cite journal |last1=Stearns |first1=Adam T. |last2=Balakrishnan |first2=Anita |last3=Rhoads |first3=David B. |last4=Tavakkolizadeh |first4=Ali |date=May 2010 |title=Rapid Upregulation of Sodium-Glucose Transporter SGLT1 in Response to Intestinal Sweet Taste Stimulation |url=https://journals.lww.com/00000658-201005000-00013 |journal=Annals of Surgery |language=en |volume=251 |issue=5 |pages=865–871 |doi=10.1097/SLA.0b013e3181d96e1f |issn=0003-4932 |pmc=4123655 |pmid=20395849}}

File:Functioning vs not Function CFTR.png

The Cystic Fibrosis Transport Regulator (CFTR) works by binding two ATP to the A1 and A2, ATP-binding domain. This opens the CFTR channel and allows chloride ions to flow into the lungs and airway lumen. This influx of negatively charged chloride ions into the airway lumen causes sodium to move into the airway lumen to balance the negative charge. Water then moves in with the sodium to balance the osmotic pressure and ultimately leads to the thinning of mucus. In cases of Cystic Fibrosis, the CFTR is defective and only binds a single ATP, leading to the channel failing to open and preventing chloride ions from diffusing into the airway lumen. Since chloride ions cannot diffuse in, there is no movement of sodium into the airway lumen, and no need for water to move into the lumen, leading to thick mucus that clogs and infects the airway lumen.

• Biology and pharmacology of chemical elements
• {{annotated link|Action potential}}
• {{annotated link|Calcium in biology}}
• {{annotated link|Iodine in biology}}
• {{annotated link|Magnesium in biology}}
• {{annotated link|Membrane potential}}
• {{annotated link|Potassium in biology}}
• {{annotated link|Selenium in biology}}

{{Reflist}}

• [https://archive.today/20130102112630/http://www.brookscole.com/chemistry_d/templates/student_resources/shared_resources/animations/ion_pump/ionpump.html Brooks/Cole publishers – Sodium Potassium pump]
• [http://lpi.oregonstate.edu/infocenter/minerals/potassium/ Oregon State University – Micronutrient Information Center]

{{Elements in biology}}

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