Sohini Ramachandran

{{Short description|Computational biology professor}}

{{Infobox scientist

| name = Sohini Ramachandran

| alma_mater = Stanford University

| doctoral_advisor = Marcus Feldman

| education = Stanford University

| thesis_title = The signature of historical migrations on human population genetic data

| thesis_url = https://www.worldcat.org/oclc/{{{742342820}}}

| thesis_year = 2007

| website = https://brown.edu/Research/Ramachandran_Lab/

}}

Sohini Ramachandran is professor at Brown University known for her work in evolutionary biology and population genetics.

Early life and education

Ramachandran's parents were both professors.{{Cite journal |last1=Chen |first1=Ling-Ling |last2=Claw |first2=Katrina G. |last3=Ramachandran |first3=Sohini |date=2016 |title=A two-fold challenge: the experience of women of color in genomics |journal=Genome Biology |language=en |volume=17 |issue=1 |pages=210 |doi=10.1186/s13059-016-1075-0 |issn=1474-760X |pmc=5059990 |pmid=27729075 |doi-access=free }} In the summer before her senior year of high school, Ramachandran completed a research project in plant genomics under the guidance of Marcus Feldman, which won her the fourth place prize in the 1998 Westinghouse Science Talent Search,{{Cite news |last=Chiu |first=Yvonne |date=1998-03-09 |title=Fair Oaks teen gets national honor |pages=2 |work=The Sacramento Bee |url=https://www.newspapers.com/clip/99945381/fair-oaks-teen-gets-national-honor/ |access-date=2022-04-17}} where when she was the youngest finalist in the group.{{Cite news |last=Alcala |first=Carlos |date=1998-01-28 |title=Fair Oaks teen, like sister, is on academic fast track |pages=[https://www.newspapers.com/clip/99945142/fair-oaks-teen-like-sister-is-on/],[https://www.newspapers.com/clip/99945183/] |work=The Sacramento Bee |url=https://www.newspapers.com/clip/99945142/fair-oaks-teen-like-sister-is-on/ |access-date=2022-04-17}} Ramachandran earned a B.S. from Stanford University in 2002. She went on to complete a Ph.D. at Stanford University in the Department of Biological Sciences, advised by Marcus Feldman. Her dissertation research was dissertation was titled "The signature of historical migrations on human population genetic data."{{Cite thesis |title=The signature of historical migrations on human population genetic data |url=https://www.worldcat.org/oclc/269371999 |date=2007 |language=English |first=Sohini |last=Ramachandran|oclc = 269371999}} Following her PhD, she was in the Harvard Society of Fellows as a postdoctoral researcher with John Wakeley in Harvard University's Department of Organismic and Evolutionary Biology.{{Cite web |title=Sohini Ramachandran Lab: people |url=https://brown.edu/Research/Ramachandran_Lab/people/ |access-date=2022-04-17 |website=brown.edu}} She moved to Brown University in 2010 and was promoted to professor in 2021. In 2019, she was a fellow at the Swedish Collegium for Advanced Study.{{Cite web |title=SCAS: Sohini Ramachandran |url=http://www.swedishcollegium.se/subfolders/Fellows/Invited_Fellows/2018-19/ramachandran.html |access-date=2022-01-22 |website=www.swedishcollegium.se}}

Research

Ramachandran's research group uses statistical and mathematical modeling techniques to study evolutionary biology and population genetics. Her early research examined the genetic relationships originating within people from Africa,{{Cite journal |last1=Ramachandran |first1=Sohini |last2=Deshpande |first2=Omkar |last3=Roseman |first3=Charles C. |last4=Rosenberg |first4=Noah A. |last5=Feldman |first5=Marcus W. |last6=Cavalli-Sforza |first6=L. Luca |date=2005 |title=Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa |journal=Proceedings of the National Academy of Sciences |language=en |volume=102 |issue=44 |pages=15942–15947 |doi=10.1073/pnas.0507611102 |issn=0027-8424 |pmc=1276087 |pmid=16243969|bibcode=2005PNAS..10215942R |doi-access=free }}{{Cite journal |last1=Henn |first1=Brenna M. |last2=Gignoux |first2=Christopher R. |last3=Jobin |first3=Matthew |last4=Granka |first4=Julie M. |last5=Macpherson |first5=J. M. |last6=Kidd |first6=Jeffrey M. |last7=Rodríguez-Botigué |first7=Laura |last8=Ramachandran |first8=Sohini |last9=Hon |first9=Lawrence |last10=Brisbin |first10=Abra |last11=Lin |first11=Alice A. |date=2011-03-29 |title=Hunter-gatherer genomic diversity suggests a southern African origin for modern humans |journal=Proceedings of the National Academy of Sciences |language=en |volume=108 |issue=13 |pages=5154–5162 |doi=10.1073/pnas.1017511108 |issn=0027-8424 |pmc=3069156 |pmid=21383195|doi-access=free }} where she showed that diversity decreases as distance from Africa increases.{{Cite web |last=Scudellari |first=Megan |date=June 2012 |title=Sohini Ramachandran: Population Tracker |url=https://www.the-scientist.com/scientist-to-watch/sohini-ramachandran-population-tracker-40941 |access-date=2022-04-17 |website=The Scientist Magazine® |language=en}} She has also investigated the use of genetic tools to track infectious diseases{{Cite journal |last1=Smith |first1=Katherine F. |last2=Goldberg |first2=Michael |last3=Rosenthal |first3=Samantha |last4=Carlson |first4=Lynn |last5=Chen |first5=Jane |last6=Chen |first6=Cici |last7=Ramachandran |first7=Sohini |date=2014-12-06 |title=Global rise in human infectious disease outbreaks |journal=Journal of the Royal Society Interface |volume=11 |issue=101 |pages=20140950 |doi=10.1098/rsif.2014.0950 |pmc=4223919 |pmid=25401184}}{{Cite journal |last1=Nakka |first1=Priyanka |last2=Raphael |first2=Benjamin J |last3=Ramachandran |first3=Sohini |date=2016-10-01 |title=Gene and Network Analysis of Common Variants Reveals Novel Associations in Multiple Complex Diseases |journal=Genetics |language=en |volume=204 |issue=2 |pages=783–798 |doi=10.1534/genetics.116.188391 |issn=1943-2631 |pmc=5068862 |pmid=27489002}} and shown that while more outbreaks are occurring, fewer people are getting infected.{{Cite news |last=Berman |first=Jessica |date=October 29, 2014 |title=Global Infection Outbreaks Rise over Past 30 Years |work=Voice of America News / FIND; Washington}} She has also shown a lack of genetic evidence for selection for language at the FOXP2 site.{{Cite journal |last1=Atkinson |first1=Elizabeth Grace |last2=Audesse |first2=Amanda Jane |last3=Palacios |first3=Julia Adela |last4=Bobo |first4=Dean Michael |last5=Webb |first5=Ashley Elizabeth |last6=Ramachandran |first6=Sohini |last7=Henn |first7=Brenna Mariah |date=2018-09-06 |title=No Evidence for Recent Selection at FOXP2 among Diverse Human Populations |journal=Cell |language=English |volume=174 |issue=6 |pages=1424–1435.e15 |doi=10.1016/j.cell.2018.06.048 |issn=0092-8674 |pmc=6128738 |pmid=30078708}}

Selected publications

  • {{Cite journal |last1=Li |first1=Jun Z. |last2=Absher |first2=Devin M. |last3=Tang |first3=Hua |last4=Southwick |first4=Audrey M. |last5=Casto |first5=Amanda M. |last6=Ramachandran |first6=Sohini |last7=Cann |first7=Howard M. |last8=Barsh |first8=Gregory S. |last9=Feldman |first9=Marcus |last10=Cavalli-Sforza |first10=Luigi L. |last11=Myers |first11=Richard M. |date=2008-02-22 |title=Worldwide Human Relationships Inferred from Genome-Wide Patterns of Variation |url=https://www.science.org/doi/10.1126/science.1153717 |journal=Science |language=en |volume=319 |issue=5866 |pages=1100–1104 |doi=10.1126/science.1153717 |pmid=18292342 |bibcode=2008Sci...319.1100L |s2cid=53541133 |issn=0036-8075|url-access=subscription }}
  • {{Cite journal |last1=Ramachandran |first1=Sohini |last2=Deshpande |first2=Omkar |last3=Roseman |first3=Charles C. |last4=Rosenberg |first4=Noah A. |last5=Feldman |first5=Marcus W. |last6=Cavalli-Sforza |first6=L. Luca |date=2005 |title=Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa |journal=Proceedings of the National Academy of Sciences |language=en |volume=102 |issue=44 |pages=15942–15947 |doi=10.1073/pnas.0507611102 |issn=0027-8424 |pmc=1276087 |pmid=16243969|bibcode=2005PNAS..10215942R |doi-access=free }}
  • {{Cite journal |last1=Wang |first1=Sijia |last2=Lewis |first2=Cecil M. Jr. |last3=Jakobsson |first3=Mattias |last4=Ramachandran |first4=Sohini |last5=Ray |first5=Nicolas |last6=Bedoya |first6=Gabriel |last7=Rojas |first7=Winston |last8=Parra |first8=Maria V. |last9=Molina |first9=Julio A. |last10=Gallo |first10=Carla |last11=Mazzotti |first11=Guido |date=2007-11-23 |title=Genetic Variation and Population Structure in Native Americans |journal=PLOS Genetics |language=en |volume=3 |issue=11 |pages=e185 |doi=10.1371/journal.pgen.0030185 |issn=1553-7404 |pmc=2082466 |pmid=18039031 |doi-access=free }}
  • {{Cite journal |last1=Ramachandran |first1=Sohini |last2=Rosenberg |first2=Noah A. |last3=Zhivotovsky |first3=Lev A. |last4=Feldman |first4=Marcus W. |date=2004 |title=Robustness of the inference of human population structure: A comparison of X-chromosomal and autosomal microsatellites |journal=Human Genomics |language=en |volume=1 |issue=2 |pages=87–97 |doi=10.1186/1479-7364-1-2-87 |issn=1479-7364 |pmc=3525066 |pmid=15601537 |doi-access=free }}

Honors and awards

In 2012, Ramachandran received a Sloan Research Fellowship{{Cite web |date=August 23, 2012 |title=Sohini Ramachandran, Ph.D. |url=https://www.pewtrusts.org/en/research-and-analysis/issue-briefs/2012/08/23/pew-biomedical-scholar-profile-sohini-ramachandran |access-date=2022-01-13 |website=pew.org |language=en}} and was named a Pew Scholar.{{Cite news |date=July 3, 2012 |title=Eight Women Win Pew Scholarships in the Biomedical Sciences |work=Women in Academia Report; Bartonsville}} From Brown University she has received the Henry Merritt Wriston Fellowship (2016){{Cite web |title=Sohini Ramchandran awarded Wriston Fellowship |url=https://ccmb.brown.edu/news/2016-05-04/sohini-ramchandran-awarded-wriston-fellowship |access-date=2022-04-17 |website=CCMB {{!}} Brown University |language=en}} and the Philip J. Bray Award for excellence in teaching.{{Cite web |last=Gimenes |first=Livia |date=2021-07-03 |title=Sohini Ramachandran Receives The Philip J. Bray Award For Excellence In Teaching In The Physical Sciences |url=https://awards.cs.brown.edu/2021/07/03/sohini-ramachandran-receives-philip-j-bray-award-excellence-teaching-physical-sciences/ |access-date=2022-04-17 |website=awards.cs.brown.edu |language=en}} In 2019, she received a Presidential Early Career Award in Science and Engineering.{{Cite web|title=Two Brown researchers earn top White House award for early-career scientists|url=https://www.brown.edu/news/2019-07-05/pecase|access-date=2022-01-13|website=Brown University|language=en}}{{Cite web |last=Abbey Bigler and Talylor Walter |title=PECASE Honoree Sohini Ramachandran Studies the Genetic Foundations of Traits in Diverse Populations |url=https://biobeat.nigms.nih.gov/2020/02/pecase-honoree-sohini-ramachandran-studies-the-genetic-foundations-of-traits-in-diverse-populations/ |access-date=2022-04-17 |website=NIGMS Biomedical Beat Blog |date=26 February 2020 |language=en-US}}

References

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