Sp4 transcription factor
{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Use dmy dates|date=April 2023}}
{{Infobox_gene}}
Transcription factor Sp4 is a protein that in humans is encoded by the SP4 gene.{{cite journal | vauthors = Hagen G, Müller S, Beato M, Suske G | title = Cloning by recognition site screening of two novel GT box binding proteins: a family of Sp1 related genes | journal = Nucleic Acids Research | volume = 20 | issue = 21 | pages = 5519–25 | date = Nov 1992 | pmid = 1454515 | pmc = 334381 | doi = 10.1093/nar/20.21.5519 }}{{cite web | title = Entrez Gene: SP4 Sp4 transcription factor| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6671}}
Interactions
Sp4 transcription factor has been shown to interact with E2F1.{{cite journal | vauthors = Rotheneder H, Geymayer S, Haidweger E | title = Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter | journal = Journal of Molecular Biology | volume = 293 | issue = 5 | pages = 1005–15 | date = Nov 1999 | pmid = 10547281 | doi = 10.1006/jmbi.1999.3213 }}
References
{{reflist}}
Further reading
{{refbegin | 2}}
- {{cite journal | vauthors = Suske G | title = The Sp-family of transcription factors | journal = Gene | volume = 238 | issue = 2 | pages = 291–300 | date = Oct 1999 | pmid = 10570957 | doi = 10.1016/S0378-1119(99)00357-1 }}
- {{cite journal | vauthors = Hagen G, Dennig J, Preiss A, Beato M, Suske G | title = Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3 | journal = The Journal of Biological Chemistry | volume = 270 | issue = 42 | pages = 24989–94 | date = Oct 1995 | pmid = 7559627 | doi = 10.1074/jbc.270.42.24989 | doi-access = free }}
- {{cite journal | vauthors = Kalff-Suske M, Kunz J, Grzeschik KH, Suske G | title = Human Sp4 transcription factor gene (SP4) maps to chromosome 7p15 | journal = Genomics | volume = 26 | issue = 3 | pages = 631–3 | date = Apr 1995 | pmid = 7607696 | doi = 10.1016/0888-7543(95)80191-N }}
- {{cite journal | vauthors = Majello B, De Luca P, Hagen G, Suske G, Lania L | title = Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1 | journal = Nucleic Acids Research | volume = 22 | issue = 23 | pages = 4914–21 | date = Nov 1994 | pmid = 7800480 | pmc = 523756 | doi = 10.1093/nar/22.23.4914 }}
- {{cite journal | vauthors = Rotheneder H, Geymayer S, Haidweger E | title = Transcription factors of the Sp1 family: interaction with E2F and regulation of the murine thymidine kinase promoter | journal = Journal of Molecular Biology | volume = 293 | issue = 5 | pages = 1005–15 | date = Nov 1999 | pmid = 10547281 | doi = 10.1006/jmbi.1999.3213 }}
- {{cite journal | vauthors = Nguyên-Trân VT, Kubalak SW, Minamisawa S, Fiset C, Wollert KC, Brown AB, Ruiz-Lozano P, Barrere-Lemaire S, Kondo R, Norman LW, Gourdie RG, Rahme MM, Feld GK, Clark RB, Giles WR, Chien KR | title = A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages | journal = Cell | volume = 102 | issue = 5 | pages = 671–82 | date = Sep 2000 | pmid = 11007485 | doi = 10.1016/S0092-8674(00)00089-1 | s2cid = 3017990 | doi-access = free }}
- {{cite journal | vauthors = Lerner LE, Gribanova YE, Ji M, Knox BE, Farber DB | title = Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements | journal = The Journal of Biological Chemistry | volume = 276 | issue = 37 | pages = 34999–5007 | date = Sep 2001 | pmid = 11438531 | doi = 10.1074/jbc.M103301200 | doi-access = free }}
- {{cite journal | vauthors = Lerner LE, Gribanova YE, Whitaker L, Knox BE, Farber DB | title = The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX | journal = The Journal of Biological Chemistry | volume = 277 | issue = 29 | pages = 25877–83 | date = Jul 2002 | pmid = 11943774 | doi = 10.1074/jbc.M201407200 | doi-access = free }}
- {{cite journal | vauthors = Lee DK, Suh D, Edenberg HJ, Hur MW | title = POZ domain transcription factor, FBI-1, represses transcription of ADH5/FDH by interacting with the zinc finger and interfering with DNA binding activity of Sp1 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 30 | pages = 26761–8 | date = Jul 2002 | pmid = 12004059 | doi = 10.1074/jbc.M202078200 | doi-access = free }}
- {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts | journal = Molecular Vision | volume = 8 | pages = 196–204 | date = Jun 2002 | pmid = 12107411 }}
- {{cite journal | vauthors = Davis W, Chen ZJ, Ile KE, Tew KD | title = Reciprocal regulation of expression of the human adenosine 5'-triphosphate binding cassette, sub-family A, transporter 2 (ABCA2) promoter by the early growth response-1 (EGR-1) and Sp-family transcription factors | journal = Nucleic Acids Research | volume = 31 | issue = 3 | pages = 1097–107 | date = Feb 2003 | pmid = 12560508 | pmc = 149212 | doi = 10.1093/nar/gkg192 }}
- {{cite journal | vauthors = Hong J, Samudio I, Liu S, Abdelrahim M, Safe S | title = Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins | journal = Endocrinology | volume = 145 | issue = 12 | pages = 5774–85 | date = Dec 2004 | pmid = 15345676 | doi = 10.1210/en.2004-0686 | doi-access = free }}
- {{cite journal | vauthors = Phillips RJ, Tyson-Capper Née Pollard AJ, Bailey J, Robson SC, Europe-Finner GN | title = Regulation of expression of the chorionic gonadotropin/luteinizing hormone receptor gene in the human myometrium: involvement of specificity protein-1 (Sp1), Sp3, Sp4, Sp-like proteins, and histone deacetylases | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 90 | issue = 6 | pages = 3479–90 | date = Jun 2005 | pmid = 15788387 | doi = 10.1210/jc.2004-1962 | doi-access = free }}
- {{cite journal | vauthors = Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S | title = Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins | journal = Endocrinology | volume = 147 | issue = 7 | pages = 3285–95 | date = Jul 2006 | pmid = 16574784 | doi = 10.1210/en.2006-0081 | doi-access = }}
- {{cite journal | vauthors = Gao YQ, Danciger M, Ozgul RK, Gribanova Y, Jacobson S, Farber DB | title = Association of the Asn306Ser variant of the SP4 transcription factor and an intronic variant in the beta-subunit of transducin with digenic disease | journal = Molecular Vision | volume = 13 | pages = 287–92 | year = 2007 | pmid = 17356515 | pmc = 2633482 }}
{{refend}}
External links
- {{MeshName|Sp4+Transcription+Factor}}
{{PDB Gallery|geneid=6671}}
{{Transcription factors|g2}}
Category:Transcription factors
{{gene-7-stub}}