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Spondin 1

{{Short description|Protein-coding gene in the species Homo sapiens}}

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Spondin-1 (also known as F-spondin) is a protein that in humans is encoded by the SPON1 gene.{{cite journal |vauthors=Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 | date = Apr 1999| pmid = 9872452 | doi =10.1093/dnares/5.5.277 | doi-access = free }} It is secreted by cells of the floor plate and may be involved in axon guidance{{cite web | title = Entrez Gene: SPON1 spondin 1, extracellular matrix protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10418}} The protein contains 807 amino acids and is structurally composed of six thrombospondin domains, one reelin domain, and one spondin domain.

References

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Further reading

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  • {{cite journal |vauthors=Nakajima D, Okazaki N, Yamakawa H |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=10.1093/dnares/9.3.99 |doi-access=free }}
  • {{cite journal |vauthors=Klar A, Baldassare M, Jessell TM |title=F-spondin: a gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension |journal=Cell |volume=69 |issue= 1 |pages= 95–110 |year= 1992 |pmid= 1555244 |doi=10.1016/0092-8674(92)90121-R |s2cid=14880785 }}
  • {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 |doi-access=free }}
  • {{cite journal |vauthors=Miyamoto K, Morishita Y, Yamazaki M |title=Isolation and characterization of vascular smooth muscle cell growth promoting factor from bovine ovarian follicular fluid and its cDNA cloning from bovine and human ovary |journal=Arch. Biochem. Biophys. |volume=390 |issue= 1 |pages= 93–100 |year= 2001 |pmid= 11368520 |doi= 10.1006/abbi.2001.2367 }}
  • {{cite journal |vauthors=Gonzalez de Peredo A, Klein D, Macek B |title=C-mannosylation and o-fucosylation of thrombospondin type 1 repeats |journal=Mol. Cell. Proteomics |volume=1 |issue= 1 |pages= 11–8 |year= 2002 |pmid= 12096136 |doi=10.1074/mcp.M100011-MCP200 |doi-access=free }}
  • {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
  • {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
  • {{cite journal |vauthors=Ho A, Südhof TC |title=Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2548–53 |year= 2004 |pmid= 14983046 |doi= 10.1073/pnas.0308655100 | pmc=356987 |bibcode=2004PNAS..101.2548H |doi-access=free }}
  • {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
  • {{cite journal |vauthors=Pyle-Chenault RA, Stolk JA, Molesh DA |title=VSGP/F-spondin: a new ovarian cancer marker |journal=Tumour Biol. |volume=26 |issue= 5 |pages= 245–57 |year= 2005 |pmid= 16103746 |doi= 10.1159/000087379 |s2cid=13409234 }}
  • {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 |doi-access= free }}
  • {{cite journal |vauthors=Kitagawa M, Kudo Y, Iizuka S |title=Effect of F-spondin on cementoblastic differentiation of human periodontal ligament cells |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 3 |pages= 1050–6 |year= 2006 |pmid= 16965763 |doi= 10.1016/j.bbrc.2006.08.142 |url=http://ir.lib.hiroshima-u.ac.jp/files/public/1/17040/20141016130157875200/BBRC_349_1050.pdf }}

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External links

  • {{PDBe-KB2|Q9HCB6|Spondin-1}}

{{PDB Gallery|geneid=10418}}

Category:Extracellular matrix proteins

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