SprA1/SprA1as toxin/antitoxin system

The SprA1/SPrA1as toxin/antitoxin system identified in Staphylococcus aureus, belongs to the Type I system encoding toxin protein: SprA1 and antitoxin RNA: SprA1as. The SprA1as postranscriptionally regulates SprA1 encoding small membrane damaging protein PepA1.{{cite journal | vauthors = Sayed N, Jousselin A, Felden B | title = A cis-antisense RNA acts in trans in Staphylococcus aureus to control translation of a human cytolytic peptide | journal = Nature Structural & Molecular Biology | volume = 19 | issue = 1 | pages = 105–12 | date = December 2011 | pmid = 22198463 | doi = 10.1038/nsmb.2193 | s2cid = 8217681 | url = http://www.hal.inserm.fr/inserm-00696345/document }}{{cite journal | vauthors = Sayed N, Nonin-Lecomte S, Réty S, Felden B | title = Functional and structural insights of a Staphylococcus aureus apoptotic-like membrane peptide from a toxin-antitoxin module | journal = The Journal of Biological Chemistry | volume = 287 | issue = 52 | pages = 43454–63 | date = December 2012 | pmid = 23129767 | pmc = 3527932 | doi = 10.1074/jbc.M112.402693 | doi-access = free }}