Stomatin

Stomatin is a 31 kDa integral membrane protein, named after the rare human haemolytic anaemia hereditary stomatocytosis. This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia.

This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia.

Although the wide distribution of stomatin and its constitutive expression suggest an important role for this protein in cell biology, perhaps as a “house-keeping” component, its function remains undetermined. The massive presence of stomatin in membrane-protruding folds and extensions suggests a possible structural role for this protein in the formation of these structures and/or the anchorage to the actin cytoskeleton.

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• {{cite journal |vauthors=Snyers L, Umlauf E, Prohaska R |title=Cysteine 29 is the major palmitoylation site on stomatin. |journal=FEBS Lett. |volume=449 |issue= 2–3 |pages= 101–4 |year= 1999 |pmid= 10338112 |doi=10.1016/S0014-5793(99)00417-2 |s2cid=19587098 |doi-access=free }}
• {{cite journal |vauthors=Zhang JZ, Hayashi H, Ebina Y, etal |title=Association of stomatin (band 7.2b) with Glut1 glucose transporter |journal=Arch. Biochem. Biophys. |volume=372 |issue= 1 |pages= 173–8 |year= 1999 |pmid= 10562431 |doi= 10.1006/abbi.1999.1489 }}
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• {{cite journal |vauthors=Fricke B, Argent AC, Chetty MC, etal |title=The "stomatin" gene and protein in overhydrated hereditary stomatocytosis |journal=Blood |volume=102 |issue= 6 |pages= 2268–77 |year= 2003 |pmid= 12750157 |doi= 10.1182/blood-2002-06-1705 |doi-access= free }}
• {{cite journal |vauthors=Green JB, Fricke B, Chetty MC, etal |title=Eukaryotic and prokaryotic stomatins: the proteolytic link |journal=Blood Cells Mol. Dis. |volume=32 |issue= 3 |pages= 411–22 |year= 2005 |pmid= 15121101 |doi= 10.1016/j.bcmd.2004.01.016 }}
• {{cite journal |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 | pmc=2734081 |bibcode=2004Natur.429..369H }}

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• {{PDBe-KB2|P54116|Mouse Erythrocyte band 7 integral membrane protein}}

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Category:Membrane proteins