Streptococcus equinus

S. equinus, which is always abundant in the feces of horses, was first isolated from the air in 1906 by Andrewes and Horder due to the presence of dried horse manure, common in most cities at the time.{{cite book |author=Hagan WA |title= Hagan and Bruner's Microbiology and Infectious Diseases of Domestic Animals |page=195 |year=1988}}

In 1910, Winslow and Palmer verified the findings of Andrewes and Horder and reported further findings in both cattle and human feces.{{cite journal |vauthors=Hodge HM, Sherman JM |title= Streptococcus equinus|journal=J Bacteriol |volume=33 |pages=283–289 |date=March 1937 |pmc=545391 |issue=3 |pmid=16559995|doi= 10.1128/JB.33.3.283-289.1937}}

After the bacterium was discovered in 1906, the term Streptococcus equinus became a convenient “wastebasket” into which nonhemolytic streptococci that do not ferment lactose and mannitol were categorized. The classification of all streptococci that fail to ferment lactose into one large category has made the classification of S. equinus very difficult.

File:Phylogeny of Streptococcus equinus.png species{{cite book |author= Logan, N |title=Bacterial Systematics |pages=194 |date=July 2009 |url=https://books.google.com/books?id=7cP24IY9dn0C&dq=unrooted+tree+of+streptococcus+equinus+1991+bentley+et+al&pg=PA194 |isbn= 9781444313932}}]]

However, as shown to the left, it is known that S. equinus, a nonenterococcal, group D streptococcus, is most closely related to the species S. bovis. In 2003, S. bovis and S. equinus were found to have a 99% 16S rRNA sequence similarity.{{cite journal |doi=10.1099/ijs.0.02361-0 |title=Reappraisal of the taxonomy of the Streptococcus bovis/Streptococcus equinus complex and related species: Description of Streptococcus gallolyticus subsp. Gallolyticus subsp. Nov., S. Gallolyticus subsp. Macedonicus subsp. Nov. And S. Gallolyticus subsp. Pasteurianus subsp. Nov |year=2003 |last1=Schlegel |first1=L. |journal=International Journal of Systematic and Evolutionary Microbiology |volume=53 |issue=3 |pages=631–45 |pmid=12807180 |last2=Grimont |first2=F |last3=Ageron |first3=E |last4=Grimont |first4=PA |last5=Bouvet |first5=A|doi-access=free }} While particularly similar in phylogeny they differ in biochemical reactions and physiological characteristics.

The taxonomy of the organisms designated as S. bovis and S. equinus has a very complex history. S. equinus and S. bovis were reported to be synonyms by Farrow et al. in 1984, but were listed as separate species in Bergey's Manual of Systematic Bacteriology in 1986.{{cite journal |vauthors=Devriese L, Vandamme P, Pot B, Vanrobaeys M, Kersters K, Haesebrouck F |title=Differentiation between Streptococcus gallolyticus Strains of Human Clinical and Veterinary Origins and Streptococcus bovis Strains from the Intestinal Tracts of Ruminants |journal= J. Clin. Microbiol. |date=Dec 1998 |url= |pmid=9817865 |volume=36 |issue=12 |pages=3520–3 |pmc=105232|doi=10.1128/JCM.36.12.3520-3523.1998 }} Recently, the situation has become more complex by the description of two novel species for strains originally identified as S. bovis as actually S. caprinus, and S. gallolyticus. The taxonomy of S. equinus has yet to be fully resolved.{{cite journal |author=Deibel RH |title= The Group D Streptococci|journal= Bacteriol Rev |pages=330–366 |date=Sep 1964 |pmc=441228 |volume=28 |issue=3 |pmid=14220658|doi= 10.1128/MMBR.28.3.330-366.1964}}

A prominent characteristic of S. equinus is its inability to ferment lactose and mannitol. Moreover, it is nonhemolytic and not known to be pathogenic for animals.

Generally, it appears as short chains of spherical or ovoid cells. These chains are somewhat longer in broth cultures than milk. Some cultures form extremely long chains in broth.

S. equinus has a high minimum temperature of growth, evidenced by little or no growth in gelatin cultures at temperatures lower than 21 °C. No growth occurs at 10 or 15 °C, and growth is very slow at 21 °C. The maximum temperature of growth takes place at 45 °C, and 47 °C where growth seldom occurs. No growth occurs at 48 °C.

It does not grow well in nor can it coagulate milk. However, it has a high fermentative power in glucose broth. The organism grows with vigor in glucose-peptone-litmus milk.

It has a higher resistance to temperature than that possessed by pathogenic streptococci, but substantially lower than that of thermoduric streptococci.

Most of the other properties of S. equinus have not yet been determined.

S. equinus is one of the rare Gram-positive bacteria that may cause bacteremia and endocarditis in humans, but infection with this organism is very rare in humans.{{cite web |author=Wallace S |title=Group D non-enteroccal streptococcus |publisher= Johns Hopkins|volume=24 |date=September 2005 |url=https://www.google.com/search?q=Provided+by+Sharon+Wallace,+Division+of+Outbreak+Investigation,+Maryland+Department+of+Health+and+Mental+Hygiene.}}

Among the rare published cases of S. equinus reported are: infective endocarditis,{{cite journal |vauthors=Elliott PM, Williams H, ((Brooks IAB)) |title= A case of infective endocarditis in a farmer caused by Streptococcus equinus|journal=European Heart Journal |volume=14 |pages=1292–1293 |year=1993 |pmid=8223744 |doi=10.1093/eurheartj/14.9.1292 |issue=9|doi-access=free }} and peritonitis.

In 1993, a case was reported of a farmer with documented aortic valve disease who developed bacterial endocarditis due to S. equinus. The case report also noted that S. equinus is a rare pathogen in man and its acquisition may be related to the subject’s occupation.

In 1998, a case of S. equinus peritonitis in a patient on continuous ambulatory peritoneal dialysis (CAPD) was reported.{{cite journal |pmid=9932668 |year=1998 |last1=Tuncer |first1=M |last2=Ozcan |first2=S |last3=Vural |first3=T |last4=Sarikaya |first4=M |last5=Süleymanlar |first5=G |last6=Yakupoglu |first6=G |last7=Ersoy |first7=FF |title=Streptococcus equinus peritonitis in a CAPD patient |volume=18 |issue=6 |pages=654 |journal=Peritoneal Dialysis International|doi=10.1177/089686089801800617 |doi-access=free }} This case reported that S. equinus is a rare but easily treatable cause of peritonitis in CAPD patients.

In 2000, a woman with no underlying cardiac abnormalities developed S. equinus endocarditis.{{cite journal |vauthors=Sechi LA, Ciani R |title= Streptococcus equinus endocarditis in a patient with pulmonary histiocytosis X |volume=31 |pages=598–600 |year=1999 |pmid=10680994 |issue=6 |journal=Scandinavian Journal of Infectious Diseases |doi=10.1080/00365549950164526}} However, the patient also had pulmonary histiocytosis X. While this may have been a coincidence, such patients have many abnormalities of the immune system including imbalance of the immunoregulatory cell system and a decreased production of natural antibodies. Such abnormalities can predispose the patients with histiocytosis X to the development of bacterial infections, and a similar mechanism may have taken place in this patient.

Overall, while this organism has been isolated from the human intestine, currently it has not been reported to cause endocarditis in patients without history of cardiac disease or another underlying condition.{{cite journal |author=Noble CJ.|title=Carriage of group D streptococci in the human bowel|journal= J Clin Pathol|volume=31 |pages=1182–1186 |year=1978 |pmc= 1145528 |issue=12 |doi=10.1136/jcp.31.12.1182 |pmid=107199}}

To obtain a definitive discrimination between S. equinus and S. bovis, extensive further studies are required. Additional DNA-DNA hybridization studies or genomic and proteomic comparison experiments of the two species could lead to more definitive results.{{cite journal |vauthors=Hinse T, Vollmer M, Erhard M, ((Welker ERB)), Moore K, Kleesiek J |title=Differentiation of species of the Streptococcus bovis/equinus-complex by MALDI-TOF Mass Spectrometry in comparison to sodA sequence analyses |journal= Dreier Syst Appl Microbiol |volume=34 |pages=52–57 |date=Jan 2011 |doi=10.1016/j.syapm.2010.11.010 |pmid=21247715 |issue=1}} Also, further studies using new techniques such as MALDI-TOF may also be effective.

{{Reflist}}

• [https://www.ncbi.nlm.nih.gov/pubmed/?term=%22Streptococcus+equinus%22%5BTitle%5D+AND+%22loattrfree+full+text%22%5Bsb%5D "Streptococcus equinus": free-full text articles in PubMed]
• [http://bacdive.dsmz.de/index.php?search=14727&submit=Search Type strain of Streptococcus equinus at BacDive - the Bacterial Diversity Metadatabase]

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Category:Streptococcaceae

Category:Bacteria described in 1906